7U5I
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2QCJ
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![BU of 2qcj by Molmil](/molmil-images/mine/2qcj) | Native Structure of Lyp | Descriptor: | Tyrosine-protein phosphatase non-receptor type 22 | Authors: | Sun, J.P, Yu, X, Zhang, Z.Y. | Deposit date: | 2007-06-19 | Release date: | 2007-11-20 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of Lyp and its complex with a selective inhibitor To be Published
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3H1K
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![BU of 3h1k by Molmil](/molmil-images/mine/3h1k) | Chicken cytochrome BC1 complex with ZN++ and an iodinated derivative of kresoxim-methyl bound | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, CARDIOLIPIN, Coenzyme Q10, ... | Authors: | Berry, E.A, Zhang, Z, Bellamy, H.D, Huang, L.S. | Deposit date: | 2009-04-12 | Release date: | 2009-04-28 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (3.48 Å) | Cite: | Crystallographic location of two Zn(2+)-binding sites in the avian cytochrome bc(1) complex Biochim.Biophys.Acta, 1459, 2000
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2YIN
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![BU of 2yin by Molmil](/molmil-images/mine/2yin) | STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1. | Descriptor: | DEDICATOR OF CYTOKINESIS PROTEIN 2, RAS-RELATED C3 BOTULINUM TOXIN SUBSTRATE 1 | Authors: | Kulkarni, K.A, Yang, J, Zhang, Z, Barford, D. | Deposit date: | 2011-05-16 | Release date: | 2011-05-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Multiple Factors Confer Specific Cdc42 and Rac Protein Activation by Dedicator of Cytokinesis (Dock) Nucleotide Exchange Factors. J.Biol.Chem., 286, 2011
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3J2M
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![BU of 3j2m by Molmil](/molmil-images/mine/3j2m) | The X-ray structure of the gp15 hexamer and the model of the gp18 protein fitted into the cryo-EM reconstruction of the extended T4 tail | Descriptor: | Tail connector protein Gp15, Tail sheath protein Gp18 | Authors: | Fokine, A, Zhang, Z, Kanamaru, S, Bowman, V.D, Aksyuk, A, Arisaka, F, Rao, V.B, Rossmann, M.G. | Deposit date: | 2012-11-09 | Release date: | 2013-03-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (15 Å) | Cite: | The molecular architecture of the bacteriophage t4 neck. J.Mol.Biol., 425, 2013
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3J2N
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![BU of 3j2n by Molmil](/molmil-images/mine/3j2n) | The X-ray structure of the gp15 hexamer and the model of the gp18 protein fitted into the cryo-EM reconstruction of the contracted T4 tail | Descriptor: | Tail connector protein Gp15, Tail sheath protein Gp18 | Authors: | Fokine, A, Zhang, Z, Kanamaru, S, Bowman, V.D, Aksyuk, A, Arisaka, F, Rao, V.B, Rossmann, M.G. | Deposit date: | 2012-11-10 | Release date: | 2013-03-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (16 Å) | Cite: | The molecular architecture of the bacteriophage t4 neck. J.Mol.Biol., 425, 2013
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6LYI
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6LSA
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![BU of 6lsa by Molmil](/molmil-images/mine/6lsa) | Complex structure of bovine herpesvirus 1 glycoprotein D and bovine nectin-1 IgV | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein D, ... | Authors: | Yue, D, Chen, Z.J, Yang, F.L, Ye, F, Lin, S, Cheng, Y.W, Wang, J.C, Chen, Z.M, Lin, X, Yang, J, Chen, H, Zhang, Z.L, You, Y, Sun, H.L, Wen, A, Wang, L.L, Zheng, Y, Cao, Y, Li, Y.H, Lu, G.W. | Deposit date: | 2020-01-17 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.204 Å) | Cite: | Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor. Sci Adv, 6, 2020
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8JG8
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6LS9
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![BU of 6ls9 by Molmil](/molmil-images/mine/6ls9) | Crystal structure of bovine herpesvirus 1 glycoprotein D | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein D | Authors: | Yue, D, Chen, Z.J, Yang, F.L, Ye, F, Lin, S, Cheng, Y.W, Wang, J.C, Chen, Z.M, Lin, X, Yang, J, Chen, H, Zhang, Z.L, You, Y, Sun, H.L, Wen, A, Wang, L.L, Zheng, Y, Cao, Y, Li, Y.H, Lu, G.W. | Deposit date: | 2020-01-17 | Release date: | 2020-06-17 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.503 Å) | Cite: | Crystal structure of bovine herpesvirus 1 glycoprotein D bound to nectin-1 reveals the basis for its low-affinity binding to the receptor. Sci Adv, 6, 2020
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7Y62
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![BU of 7y62 by Molmil](/molmil-images/mine/7y62) | Crystal structure of human TFEB HLHLZ domain | Descriptor: | Transcription factor EB | Authors: | Yang, G, Li, P, Lin, Y, Liu, Z, Sun, H, Zhao, Z, Fang, P, Wang, J. | Deposit date: | 2022-06-18 | Release date: | 2023-03-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A small-molecule drug inhibits autophagy gene expression through the central regulator TFEB. Proc.Natl.Acad.Sci.USA, 120, 2023
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5KQL
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5KQP
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![BU of 5kqp by Molmil](/molmil-images/mine/5kqp) | Crystal structure of Apo-form LMW-PTP | Descriptor: | Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.052 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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5KQG
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1XI2
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![BU of 1xi2 by Molmil](/molmil-images/mine/1xi2) | Quinone Reductase 2 in Complex with Cancer Prodrug CB1954 | Descriptor: | 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE, FLAVIN-ADENINE DINUCLEOTIDE, NRH dehydrogenase [quinone] 2, ... | Authors: | Fu, Y, Buryanovskyy, L, Zhang, Z. | Deposit date: | 2004-09-21 | Release date: | 2005-08-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Crystal structure of quinone reductase 2 in complex with cancer prodrug CB1954 Biochem.Biophys.Res.Commun., 336, 2005
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1LCY
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![BU of 1lcy by Molmil](/molmil-images/mine/1lcy) | Crystal Structure of the Mitochondrial Serine Protease HtrA2 | Descriptor: | HtrA2 serine protease | Authors: | Li, W, Srinivasula, S.M, Chai, J, Li, P, Wu, J.W, Zhang, Z, Alnemri, E.S, Shi, Y. | Deposit date: | 2002-04-07 | Release date: | 2002-05-22 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural insights into the pro-apoptotic function of mitochondrial serine protease HtrA2/Omi. Nat.Struct.Biol., 9, 2002
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5KQM
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![BU of 5kqm by Molmil](/molmil-images/mine/5kqm) | Co-crystal structure of LMW-PTP in complex with MES | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Low molecular weight phosphotyrosine protein phosphatase | Authors: | Wang, J, Zhang, Z.-Y, Yu, Z.-H. | Deposit date: | 2016-07-06 | Release date: | 2016-10-12 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Inhibition of low molecular weight protein tyrosine phosphatase by an induced-fit mechanism. J.Med.Chem., 2016
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6M4P
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![BU of 6m4p by Molmil](/molmil-images/mine/6m4p) | Cytochrome P450 monooxygenase StvP2 substrate-bound structure | Descriptor: | 6-methoxy-streptovaricin C, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | Deposit date: | 2020-03-08 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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1AQC
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![BU of 1aqc by Molmil](/molmil-images/mine/1aqc) | X11 PTB DOMAIN-10MER PEPTIDE COMPLEX | Descriptor: | PEPTIDE, X11 | Authors: | Lee, C.-H, Zhang, Z, Kuriyan, J. | Deposit date: | 1997-07-28 | Release date: | 1997-12-24 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Sequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domain. EMBO J., 16, 1997
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4DGP
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![BU of 4dgp by Molmil](/molmil-images/mine/4dgp) | The wild-type Src homology 2 (SH2)-domain containing protein tyrosine phosphatase-2 (SHP2) | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. | Deposit date: | 2012-01-26 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
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5BK8
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![BU of 5bk8 by Molmil](/molmil-images/mine/5bk8) | Cancer-associated SHP2/T507K mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Zhang, R.Y, Zhang, Z.Y. | Deposit date: | 2019-06-01 | Release date: | 2020-04-08 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Mechanistic insights explain the transforming potential of the T507K substitution in the protein-tyrosine phosphatase SHP2. J.Biol.Chem., 295, 2020
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3KAE
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![BU of 3kae by Molmil](/molmil-images/mine/3kae) | Cdc27 N-terminus | Descriptor: | CHLORIDE ION, GLYCEROL, Possible protein of nuclear scaffold, ... | Authors: | Barford, D, Zhang, Z, Roe, S.M. | Deposit date: | 2009-10-19 | Release date: | 2010-03-23 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.298 Å) | Cite: | Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architecture J.Mol.Biol., 397, 2010
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3J2O
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![BU of 3j2o by Molmil](/molmil-images/mine/3j2o) | Model of the bacteriophage T4 fibritin based on the cryo-EM reconstruction of the contracted T4 tail containing the phage collar and whiskers | Descriptor: | Fibritin | Authors: | Fokine, A, Zhang, Z, Kanamaru, S, Bowman, V.D, Aksyuk, A.A, Arisaka, F, Rao, V.B, Rossmann, M.G. | Deposit date: | 2012-11-12 | Release date: | 2013-03-06 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (25 Å) | Cite: | The molecular architecture of the bacteriophage t4 neck. J.Mol.Biol., 425, 2013
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5VRF
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![BU of 5vrf by Molmil](/molmil-images/mine/5vrf) | CryoEM Structure of the Zinc Transporter YiiP from helical crystals | Descriptor: | Cadmium and zinc efflux pump FieF, ZINC ION | Authors: | Coudray, N, Lopez-Redondo, M, Zhang, Z, Alexopoulos, J, Stokes, D.L, Transcontinental EM Initiative for Membrane Protein Structure (TEMIMPS) | Deposit date: | 2017-05-10 | Release date: | 2018-03-14 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Structural basis for the alternating access mechanism of the cation diffusion facilitator YiiP. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4DGX
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![BU of 4dgx by Molmil](/molmil-images/mine/4dgx) | LEOPARD Syndrome-Associated SHP2/Y279C mutant | Descriptor: | Tyrosine-protein phosphatase non-receptor type 11 | Authors: | Yu, Z.H, Xu, J, Walls, C.D, Chen, L, Zhang, S, Wu, L, Wang, L.N, Liu, S.J, Zhang, Z.Y. | Deposit date: | 2012-01-27 | Release date: | 2013-03-06 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural and Mechanistic Insights into LEOPARD Syndrome-Associated SHP2 Mutations. J.Biol.Chem., 288, 2013
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