6PWX
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![BU of 6pwx by Molmil](/molmil-images/mine/6pwx) | Cryo-EM structure of RbBP5 bound to the nucleosome | Descriptor: | DNA (146-MER), Histone H2A type 1, Histone H2B 1.1, ... | Authors: | Park, S.H, Ayoub, A, Lee, Y.T, Xu, J, Zhang, W, Zhang, B, Zhang, Y, Cianfrocco, M.A, Su, M, Dou, Y, Cho, U. | Deposit date: | 2019-07-23 | Release date: | 2019-12-18 | Last modified: | 2024-03-20 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Cryo-EM structure of the human MLL1 core complex bound to the nucleosome. Nat Commun, 10, 2019
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5LUS
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![BU of 5lus by Molmil](/molmil-images/mine/5lus) | Structures of DHBN domain of Pelecanus crispus BLM helicase | Descriptor: | BLM helicase | Authors: | Shi, J, Chen, W.-F, Zhang, B, Fan, S.-H, Ai, X, Liu, N.-N, Rety, S, Xi, X.-G. | Deposit date: | 2016-09-09 | Release date: | 2017-03-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.433 Å) | Cite: | A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation. J. Biol. Chem., 292, 2017
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5LUT
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![BU of 5lut by Molmil](/molmil-images/mine/5lut) | Structures of DHBN domain of Gallus gallus BLM helicase | Descriptor: | BLM helicase, PHOSPHATE ION | Authors: | Shi, J, Chen, W.-F, Zhang, B, Fan, S.-H, Ai, X, Liu, N.-N, Rety, S, Xi, X.-G. | Deposit date: | 2016-09-09 | Release date: | 2017-03-01 | Last modified: | 2017-04-19 | Method: | X-RAY DIFFRACTION (2.72 Å) | Cite: | A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation. J. Biol. Chem., 292, 2017
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5LUP
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![BU of 5lup by Molmil](/molmil-images/mine/5lup) | Structures of DHBN domain of human BLM helicase | Descriptor: | BLM protein, PHOSPHATE ION, POTASSIUM ION | Authors: | Shi, J, Chen, W.-F, Zhang, B, Fan, S.-H, Ai, X, Liu, N.-N, Rety, S, Xi, X.-G. | Deposit date: | 2016-09-09 | Release date: | 2017-03-01 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.032 Å) | Cite: | A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation. J. Biol. Chem., 292, 2017
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5MK5
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![BU of 5mk5 by Molmil](/molmil-images/mine/5mk5) | Structures of DHBN domain of human BLM helicase | Descriptor: | Bloom syndrome protein, IODIDE ION, POTASSIUM ION | Authors: | Shi, J, Chen, W.-F, Zhang, B, Fan, S.-H, Ai, X, Liu, N.-N, Rety, S, Xi, X.-G. | Deposit date: | 2016-12-02 | Release date: | 2017-03-01 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | A helical bundle in the N-terminal domain of the BLM helicase mediates dimer and potentially hexamer formation. J. Biol. Chem., 292, 2017
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4UUQ
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![BU of 4uuq by Molmil](/molmil-images/mine/4uuq) | Crystal structure of human mono-glyceride lipase in complex with SAR127303 | Descriptor: | 4-({[(4-chlorophenyl)sulfonyl]amino}methyl)piperidine-1-carboxylic acid, MONOGLYCERIDE LIPASE | Authors: | Griebel, G, Pichat, P, Beeske, S, Leroy, T, Redon, N, Francon, D, Bert, L, Even, L, Lopez-Grancha, M, Tolstykh, T, Sun, F, Yu, Q, Brittain, S, Arlt, H, He, T, Zhang, B, Wiederschain, D, Bertrand, T, Houtman, J, Rak, A, Vallee, F, Michot, N, Auge, F, Menet, V, Bergis, O.E, George, P, Avenet, P, Mikol, V, Didier, M, Escoubet, J. | Deposit date: | 2014-07-30 | Release date: | 2015-01-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.36 Å) | Cite: | Selective Blockade of the Hydrolysis of the Endocannabinoid 2-Arachidonoylglycerol Impairs Learning and Memory Performance While Producing Antinociceptive Activity in Rodents. Sci.Rep., 5, 2015
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6WOK
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![BU of 6wok by Molmil](/molmil-images/mine/6wok) | Crystal structure of estrogen receptor alpha in complex with receptor degrader 6 | Descriptor: | (1R,3R)-1-(2,6-difluoro-4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-2-(2-fluoro-2-methylpropyl)-3-methyl-2,3,4,9-tetrahydro-1H-beta-carboline, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, Estrogen receptor | Authors: | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Wang, X, Labadie, S. | Deposit date: | 2020-04-24 | Release date: | 2020-07-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.309 Å) | Cite: | Discovery of GNE-149 as a Full Antagonist and Efficient Degrader of Estrogen Receptor alpha for ER+ Breast Cancer. Acs Med.Chem.Lett., 11, 2020
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6XVH
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![BU of 6xvh by Molmil](/molmil-images/mine/6xvh) | carbonic anhydrase with bound arylsulfonamide- boronic acid | Descriptor: | (4-sulfamoylphenyl)boronic acid, Carbonic anhydrase 2, ZINC ION | Authors: | Perez, C, Zhang, B. | Deposit date: | 2020-01-22 | Release date: | 2021-02-03 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | An easy to assemble, fully modulable, selectiv and
colorimetric artificial bio-sensor for fingerprintting
the recognition of neurotransmitters To Be Published
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6PET
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![BU of 6pet by Molmil](/molmil-images/mine/6pet) | Crystal structure of 8-hydroxychromene compound 30 bound to estrogen receptor alpha | Descriptor: | (2S)-2-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-3-(3-hydroxyphenyl)-4-methyl-2H-1-benzopyran-8-ol, (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, CHLORIDE ION, ... | Authors: | Kiefer, J.R, Vinogradova, M, Liang, J, Wang, X, Zbieg, J, Labadie, S.S, Zhang, B, Li, J, Liang, W. | Deposit date: | 2019-06-20 | Release date: | 2019-07-17 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.203 Å) | Cite: | Discovery of a C-8 hydroxychromene as a potent degrader of estrogen receptor alpha with improved rat oral exposure over GDC-0927. Bioorg.Med.Chem.Lett., 29, 2019
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8TL1
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8TL8
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![BU of 8tl8 by Molmil](/molmil-images/mine/8tl8) | Structure of Orthoreovirus RNA Chaperone SigmaNS R6A mutant in complex with bile acid | Descriptor: | GLYCOCHOLIC ACID, Protein sigma-NS | Authors: | Prasad, B.V.V, Zhao, B, Hu, L, Neetu, N. | Deposit date: | 2023-07-26 | Release date: | 2024-03-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of orthoreovirus RNA chaperone sigma NS, a component of viral replication factories. Nat Commun, 15, 2024
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8TKA
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1ILO
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![BU of 1ilo by Molmil](/molmil-images/mine/1ilo) | NMR structure of a thioredoxin, MtH895, from the archeon Methanobacterium thermoautotrophicum strain delta H. | Descriptor: | conserved hypothetical protein MtH895 | Authors: | Bhattacharyya, S, Habibi-Nazhad, B, Slupsky, C.M, Sykes, B.D, Wishart, D.S, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2001-05-08 | Release date: | 2001-11-14 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Identification of a novel archaebacterial thioredoxin: determination of function through structure. Biochemistry, 41, 2002
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6J31
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![BU of 6j31 by Molmil](/molmil-images/mine/6j31) | Crystal Structure Analysis of the Glycotransferase of kitacinnamycin | Descriptor: | (2E,2'E)-3,3'-(1,2-phenylene)di(prop-2-enoic acid), DBB-DSG-VAL-MEA-VAL-GLY-GLY-DVA-DLE, kcn28 | Authors: | Shi, J, Liu, C.L, Zhang, B, Guo, W.J, Zhu, J.P, Xu, X, Xu, Q, Jiao, R.H, Tan, R.X, Ge, H.M. | Deposit date: | 2019-01-03 | Release date: | 2020-01-15 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.244 Å) | Cite: | Genome mining and biosynthesis of kitacinnamycins as a STING activator. Chem Sci, 10, 2019
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6J32
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![BU of 6j32 by Molmil](/molmil-images/mine/6j32) | Crystal Structure Analysis of the Glycotransferase of kitacinnamycin | Descriptor: | Kcn28 | Authors: | Shi, J, Liu, C.L, Zhang, B, Guo, W.J, Zhu, J.P, Xu, X, Xu, Q, Jiao, R.H, Tan, R.X, Ge, H.M. | Deposit date: | 2019-01-03 | Release date: | 2020-01-15 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Genome mining and biosynthesis of kitacinnamycins as a STING activator. Chem Sci, 10, 2019
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6DF6
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![BU of 6df6 by Molmil](/molmil-images/mine/6df6) | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16ab | Descriptor: | (8R)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, GLYCEROL | Authors: | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. | Deposit date: | 2018-05-14 | Release date: | 2019-02-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019
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1HX8
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![BU of 1hx8 by Molmil](/molmil-images/mine/1hx8) | CRYSTAL STRUCTURE OF N-TERMINAL DOMAIN OF DROSOPHILA AP180 | Descriptor: | SULFATE ION, SYNAPSE-ENRICHED CLATHRIN ADAPTOR PROTEIN LAP | Authors: | Mao, Y, Chen, J, Maynard, J.A, Zhang, B, Quiocho, F.A. | Deposit date: | 2001-01-12 | Release date: | 2001-02-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | A novel all helix fold of the AP180 amino-terminal domain for phosphoinositide binding and clathrin assembly in synaptic vesicle endocytosis. Cell(Cambridge,Mass.), 104, 2001
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6DFN
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![BU of 6dfn by Molmil](/molmil-images/mine/6dfn) | Crystal structure of estrogen receptor alpha in complex with receptor degrader 16aa | Descriptor: | (2S)-3-(3-hydroxyphenyl)-2-(4-iodophenyl)-4-methyl-2H-1-benzopyran-6-ol, (8S)-8-(4-{2-[3-(fluoromethyl)azetidin-1-yl]ethoxy}phenyl)-1,8-dihydro-2H-[1]benzopyrano[4,3-d][1]benzoxepine-5,11-diol, Estrogen receptor, ... | Authors: | Kiefer, J.R, Vinogradova, M, Liang, J, Zhang, B, Ortwine, D.F, Nettles, K.W, Nwachukwu, J.C. | Deposit date: | 2018-05-15 | Release date: | 2019-02-20 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Unexpected equivalent potency of a constrained chromene enantiomeric pair rationalized by co-crystal structures in complex with estrogen receptor alpha. Bioorg. Med. Chem. Lett., 29, 2019
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1NHO
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![BU of 1nho by Molmil](/molmil-images/mine/1nho) | Structural and Functional characterization of a Thioredoxin-like Protein from Methanobacterium thermoautotrophicum | Descriptor: | Probable Thioredoxin | Authors: | Amegbey, G.Y, Monzavi, H, Habibi-Nazhad, B, Bhattacharyya, S, Wishart, D.S. | Deposit date: | 2002-12-19 | Release date: | 2003-08-26 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Structural and Functional Characterization of a Thioredoxin-like Protein (Mt0807) from Methanobacterium thermoautotrophicum Biochemistry, 42, 2003
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1L3Q
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![BU of 1l3q by Molmil](/molmil-images/mine/1l3q) | H. rufescens abalone shell Lustrin A consensus repeat, FPGKNVNCTSGE, pH 7.4, 1-H NMR structure | Descriptor: | Lustrin A | Authors: | Evans, J.S, Wustman, B.A, Zhang, B, Morse, D.E. | Deposit date: | 2002-02-28 | Release date: | 2002-03-15 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Model peptide studies of sequence regions in the elastomeric biomineralization protein, Lustrin A. I. The C-domain consensus-PG-, -NVNCT-motif Biopolymers, 63, 2002
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8YHV
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![BU of 8yhv by Molmil](/molmil-images/mine/8yhv) | |
5TDG
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![BU of 5tdg by Molmil](/molmil-images/mine/5tdg) | |
5TDL
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![BU of 5tdl by Molmil](/molmil-images/mine/5tdl) | |
6U28
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![BU of 6u28 by Molmil](/molmil-images/mine/6u28) | Crystal structure of 1918 NS1-ED W187A in complex with the p85-beta-iSH2 domain of human PI3K | Descriptor: | Non-structural protein 1, Phosphatidylinositol 3-kinase regulatory subunit beta | Authors: | Cho, J.H, Zhao, B, Savage, N, Li, P. | Deposit date: | 2019-08-19 | Release date: | 2020-04-22 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | Molecular recognition of a host protein by NS1 of pandemic and seasonal influenza A viruses. Proc.Natl.Acad.Sci.USA, 117, 2020
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4X1N
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![BU of 4x1n by Molmil](/molmil-images/mine/4x1n) | The crystal structure of mupain-1-16 in complex with murinised human uPA at pH7.4 | Descriptor: | Urokinase-type plasminogen activator, mupain-1-16, piperidine-1-carboximidamide | Authors: | Jiang, L, Zhao, B, Xu, P, Andreasen, P, Huang, M. | Deposit date: | 2014-11-25 | Release date: | 2015-03-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | A cyclic peptidic serine protease inhibitor: increasing affinity by increasing peptide flexibility. Plos One, 9, 2014
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