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PDB: 110 results

4M5K
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BU of 4m5k by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(3-methylphenyl)-2-oxoethyl]sulfanyl}-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.296 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5L
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BU of 4m5l by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(2-methylphenyl)-2-oxoethyl]sulfanyl}-1,7-dihydro-6H-purin-6-one, CALCIUM ION, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.094 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
2P2D
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BU of 2p2d by Molmil
Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I
Descriptor: GLYCEROL, L-ASPARAGINASE I
Authors:Yun, M.-K, Nourse, A, White, S.W, Rock, C.O, Heath, R.J.
Deposit date:2007-03-07
Release date:2007-05-15
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia colil-Asparaginase I
J.Mol.Biol., 369, 2007
2P2N
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BU of 2p2n by Molmil
Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I
Descriptor: 1,2-ETHANEDIOL, ASPARAGINE, ASPARTIC ACID, ...
Authors:Yun, M.-K, Nourse, A, White, S.W, Rock, C.O, Heath, R.J.
Deposit date:2007-03-07
Release date:2007-05-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia colil-Asparaginase I
J.Mol.Biol., 369, 2007
3MK6
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BU of 3mk6 by Molmil
Substrate and Inhibitor Binding to Pank
Descriptor: ACETYL COENZYME *A, GLYCEROL, Pantothenate kinase 3
Authors:Yun, M.-K, White, S.W.
Deposit date:2010-04-14
Release date:2010-09-15
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Modulation of Pantothenate Kinase 3 Activity by Small Molecules that Interact with the Substrate/Allosteric Regulatory Domain.
Chem.Biol., 17, 2010
1ESN
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BU of 1esn by Molmil
STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A
Descriptor: MAGNESIUM ION, PANTOTHENATE KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Yun, M, Park, C.G, Kim, J.Y, Rock, C.O, Jackowski, S, Park, H.W.
Deposit date:2000-04-10
Release date:2000-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
1DC3
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BU of 1dc3 by Molmil
STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES
Descriptor: GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE
Authors:Yun, M, Park, C.G, Kim, J.Y, Park, H.W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1DC4
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BU of 1dc4 by Molmil
STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES
Descriptor: GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE, SN-GLYCEROL-3-PHOSPHATE
Authors:Yun, M, Park, C.-G, Kim, J.-Y, Park, H.-W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1DC6
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BU of 1dc6 by Molmil
STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES.
Descriptor: GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE, NICOTINAMIDE-ADENINE-DINUCLEOTIDE
Authors:Yun, M, Park, C.-G, Kim, J.-Y, Park, H.-W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1DC5
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BU of 1dc5 by Molmil
STRUCTURAL ANALYSIS OF GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE FROM ESCHERICHIA COLI: DIRECT EVIDENCE FOR SUBSTRATE BINDING AND COFACTOR-INDUCED CONFORMATIONAL CHANGES
Descriptor: GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE
Authors:Yun, M, Park, C.-G, Kim, J.-Y, Park, H.-W.
Deposit date:1999-11-04
Release date:2000-08-23
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural analysis of glyceraldehyde 3-phosphate dehydrogenase from Escherichia coli: direct evidence of substrate binding and cofactor-induced conformational changes.
Biochemistry, 39, 2000
1ESM
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BU of 1esm by Molmil
STRUCTURAL BASIS FOR THE FEEDBACK REGULATION OF ESCHERICHIA COLI PANTOTHENATE KINASE BY COENZYME A
Descriptor: COENZYME A, PANTOTHENATE KINASE
Authors:Yun, M, Park, C.G, Kim, J.Y, Rock, C.O, Jackowski, S, Park, H.W.
Deposit date:2000-04-10
Release date:2000-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural basis for the feedback regulation of Escherichia coli pantothenate kinase by coenzyme A.
J.Biol.Chem., 275, 2000
1P3R
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BU of 1p3r by Molmil
Crystal structure of the phosphotyrosin binding domain(PTB) of mouse Disabled 1(Dab1)
Descriptor: Disabled homolog 2
Authors:Yun, M, Keshvara, L, Park, C.G, Zhang, Y.M, Dickerson, J.B, Zheng, J, Rock, C.O, Curran, T, Park, H.W.
Deposit date:2003-04-18
Release date:2003-08-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structures of the Dab homology domains of mouse disabled 1 and 2.
J.Biol.Chem., 278, 2003
1OQN
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BU of 1oqn by Molmil
Crystal structure of the phosphotyrosine binding domain (PTB) of mouse Disabled 1 (Dab1)
Descriptor: Alzheimer's disease amyloid A4 protein homolog, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, Disabled homolog 1
Authors:Yun, M, Keshvara, L, Park, C.-G, Zhang, Y.-M, Dickerson, J.B, Zheng, J, Rock, C.O, Curran, T, Park, H.-W.
Deposit date:2003-03-10
Release date:2003-08-05
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structures of the Dab homology domains of mouse disabled 1 and 2
J.Biol.Chem., 278, 2003
4M5M
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BU of 4m5m by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-1,9-dihydro-6H-purine-6-thione, 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, CALCIUM ION, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.118 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5I
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BU of 4m5i by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(4-methylphenyl)-2-oxoethyl]sulfanyl}-1,7-dihydro-6H-purin-6-one, CALCIUM ION, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.08 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5J
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BU of 4m5j by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-{[2-(4-methoxyphenyl)-2-oxoethyl]sulfanyl}-1,9-dihydro-6H-purin-6-one, CHLORIDE ION, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.696 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5G
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BU of 4m5g by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 2-amino-8-[(2-oxo-2-phenylethyl)sulfanyl]-1,9-dihydro-6H-purin-6-one, CALCIUM ION, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5N
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BU of 4m5n by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 6-amino-1,9-dihydro-2H-purine-2-thione, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
4M5H
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BU of 4m5h by Molmil
The Identification, Analysis and Structure-Based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase
Descriptor: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase, 4-{[(2-amino-6-oxo-6,9-dihydro-1H-purin-8-yl)sulfanyl]methyl}benzonitrile, CALCIUM ION, ...
Authors:Yun, M, Hoagland, D, Kumar, G, Waddell, B, Rock, C.O, Lee, R.E, White, S.W.
Deposit date:2013-08-08
Release date:2014-04-02
Last modified:2023-09-20
Method:X-RAY DIFFRACTION (1.11 Å)
Cite:The identification, analysis and structure-based development of novel inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.
Bioorg.Med.Chem., 22, 2014
3V5O
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BU of 3v5o by Molmil
Structural and Mechanistic Studies of Catalysis and Sulfa Drug Resistance in Dihydropteroate Synthase
Descriptor: Dihydropteroate synthase, SULFATE ION
Authors:Yun, M, Wu, Y, Li, Z, Zhao, Y, Waddell, M.B, Ferreira, A.M, Lee, R.E, Bashford, D, White, S.W.
Deposit date:2011-12-16
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TYB
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BU of 3tyb by Molmil
Dihydropteroate Synthase in complex with pHBA and DHP+
Descriptor: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, Dihydropteroate synthase, P-HYDROXYBENZOIC ACID, ...
Authors:Yun, M.-K, White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TYE
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BU of 3tye by Molmil
Dihydropteroate Synthase in complex with DHP-STZ
Descriptor: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, 4-amino-N-(1,3-thiazol-2-yl)benzenesulfonamide, 4-{[(2-amino-4-oxo-3,4,7,8-tetrahydropteridin-6-yl)methyl]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide, ...
Authors:Yun, M.-K, White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
3TYD
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BU of 3tyd by Molmil
Dihydropteroate Synthase in complex with PPi and DHP+
Descriptor: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, Dihydropteroate synthase, PYROPHOSPHATE 2-, ...
Authors:Yun, M.-K, White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012
2HIM
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BU of 2him by Molmil
Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I
Descriptor: 1,2-ETHANEDIOL, ASPARAGINE, ASPARTIC ACID, ...
Authors:Yun, M.K, Nourse, A, White, S.W, Rock, C.O, Heath, R.J.
Deposit date:2006-06-29
Release date:2007-05-15
Last modified:2021-10-20
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia coli L-Asparaginase I.
J.Mol.Biol., 369, 2007
3TYC
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BU of 3tyc by Molmil
Dihydropteroate Synthase in complex with DHP+
Descriptor: 2-amino-6-methylidene-6,7-dihydropteridin-4(3H)-one, Dihydropteroate synthase, SULFATE ION
Authors:Yun, M.-K, White, S.W.
Deposit date:2011-09-24
Release date:2012-03-14
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Catalysis and sulfa drug resistance in dihydropteroate synthase.
Science, 335, 2012

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