8HNC
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![BU of 8hnc by Molmil](/molmil-images/mine/8hnc) | Cryo-EM structure of human OATP1B1 in complex with bilirubin | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-[5-[(Z)-(4-ethenyl-3-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-2-[[5-[(Z)-(3-ethenyl-4-methyl-5-oxidanylidene-pyrrol-2-ylidene)methyl]-3-(3-hydroxy-3-oxopropyl)-4-methyl-1H-pyrrol-2-yl]methyl]-4-methyl-1H-pyrrol-3-yl]propanoic acid, ... | Authors: | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | Deposit date: | 2022-12-07 | Release date: | 2023-09-13 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.73 Å) | Cite: | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8HND
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![BU of 8hnd by Molmil](/molmil-images/mine/8hnd) | Cryo-EM structure of human OATP1B1 in complex with estrone-3-sulfate | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Solute carrier organic anion transporter family member 1B1, ... | Authors: | Shan, Z, Yang, X, Liu, H, Nan, J, Yuan, Y, Zhang, Y. | Deposit date: | 2022-12-07 | Release date: | 2023-09-13 | Last modified: | 2023-12-20 | Method: | ELECTRON MICROSCOPY (3.19 Å) | Cite: | Cryo-EM structures of human organic anion transporting polypeptide OATP1B1. Cell Res., 33, 2023
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8HFE
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![BU of 8hfe by Molmil](/molmil-images/mine/8hfe) | Cryo-EM structure of human norepinephrine transporter NET in an inward-open state at resolution of 2.5 angstrom | Descriptor: | CHLORIDE ION, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-11-10 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFF
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![BU of 8hff by Molmil](/molmil-images/mine/8hff) | Cryo-EM structure of human norepinephrine transporter NET in the presence of norepinephrine in an inward-open state at resolution of 2.9 angstrom. | Descriptor: | L-NOREPINEPHRINE, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-11-10 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFL
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![BU of 8hfl by Molmil](/molmil-images/mine/8hfl) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant bupropion in an inward-open state at resolution of 3.0 angstrom. | Descriptor: | Bupropion, CHLORIDE ION, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-11-11 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFI
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![BU of 8hfi by Molmil](/molmil-images/mine/8hfi) | Cryo-EM structure of human norepinephrine transporter NET in the presence of the antidepressant desipramine in an inward-open state at resolution of 2.5 angstrom. | Descriptor: | 3-(10,11-DIHYDRO-5H-DIBENZO[B,F]AZEPIN-5-YL)-N-METHYLPROPAN-1-AMINE, CHLORIDE ION, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-11-10 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8HFG
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![BU of 8hfg by Molmil](/molmil-images/mine/8hfg) | Cryo-EM structure of human norepinephrine transporter NET in the presence of dopamine in an inward-open state at resolution of 3.0 angstrom. | Descriptor: | CHLORIDE ION, L-DOPAMINE, Sodium-dependent noradrenaline transporter | Authors: | Tan, J, Xiao, Y, Kong, F, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-11-10 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Molecular basis for the reuptake and inhibition of human norepinephrine transporter To Be Published
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8FY0
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![BU of 8fy0 by Molmil](/molmil-images/mine/8fy0) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-xL) | Descriptor: | Bcl-2-like protein 1, CACODYLIC ACID, Elongin-B, ... | Authors: | Olsen, S.K, Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY1
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![BU of 8fy1 by Molmil](/molmil-images/mine/8fy1) | E3:PROTAC:target ternary complex structure (VCB/753b/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8FY2
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![BU of 8fy2 by Molmil](/molmil-images/mine/8fy2) | E3:PROTAC:target ternary complex structure (VCB/WH244/BCL-2) | Descriptor: | Apoptosis regulator Bcl-2, Elongin-B, Elongin-C, ... | Authors: | Nayak, D, Lv, D, Yuan, Y, Zhang, P, Hu, W, Ruben, E, Lv, Z, Sung, P, Hromas, R, Zheng, G, Zhou, D, Olsen, S.K. | Deposit date: | 2023-01-25 | Release date: | 2024-04-10 | Method: | X-RAY DIFFRACTION (2.98 Å) | Cite: | Development and crystal structures of a potent second-generation dual degrader of BCL-2 and BCL-xL. Nat Commun, 15, 2024
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8H92
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![BU of 8h92 by Molmil](/molmil-images/mine/8h92) | |
5YT1
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![BU of 5yt1 by Molmil](/molmil-images/mine/5yt1) | |
7Y6I
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![BU of 7y6i by Molmil](/molmil-images/mine/7y6i) | Cryo-EM structure of human sodium-chloride cotransporter | Descriptor: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Nan, J, Yang, X, Shan, Z, Yuan, Y, Zhang, Y.Q. | Deposit date: | 2022-06-20 | Release date: | 2022-11-23 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Cryo-EM structure of the human sodium-chloride cotransporter NCC. Sci Adv, 8, 2022
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7Y7Y
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![BU of 7y7y by Molmil](/molmil-images/mine/7y7y) | Cryo-EM structure of human GABA transporter GAT1 bound with nipecotic acid in NaCl solution in an inward-occluded state at 2.4 angstrom | Descriptor: | (3R)-piperidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-06-22 | Release date: | 2023-04-26 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7Z
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![BU of 7y7z by Molmil](/molmil-images/mine/7y7z) | Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1, ... | Authors: | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-06-22 | Release date: | 2023-04-26 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7W
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![BU of 7y7w by Molmil](/molmil-images/mine/7y7w) | Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-06-22 | Release date: | 2023-04-26 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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7Y7V
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![BU of 7y7v by Molmil](/molmil-images/mine/7y7v) | Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1 | Authors: | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | Deposit date: | 2022-06-22 | Release date: | 2023-04-26 | Last modified: | 2023-08-16 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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