3ULL
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7ML2
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![BU of 7ml2 by Molmil](/molmil-images/mine/7ml2) | RNA polymerase II pre-initiation complex (PIC3) | Descriptor: | BJ4_G0004860.mRNA.1.CDS.1, BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, ... | Authors: | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | Deposit date: | 2021-04-27 | Release date: | 2022-02-02 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
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7MEI
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![BU of 7mei by Molmil](/molmil-images/mine/7mei) | Composite structure of EC+EC | Descriptor: | DNA (74-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Yang, C, Murakami, K. | Deposit date: | 2021-04-06 | Release date: | 2022-03-02 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
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7MKA
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![BU of 7mka by Molmil](/molmil-images/mine/7mka) | Structure of EC+EC (leading EC-focused) | Descriptor: | DNA (40-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Yang, C, Murakami, K. | Deposit date: | 2021-04-22 | Release date: | 2022-04-27 | Last modified: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
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7MK9
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![BU of 7mk9 by Molmil](/molmil-images/mine/7mk9) | Complex structure of trailing EC of EC+EC (trailing EC-focused) | Descriptor: | DNA (40-MER), DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Yang, C, Murakami, K. | Deposit date: | 2021-04-22 | Release date: | 2022-04-27 | Last modified: | 2023-05-17 | Method: | ELECTRON MICROSCOPY (3.54 Å) | Cite: | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
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6XXV
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![BU of 6xxv by Molmil](/molmil-images/mine/6xxv) | Crystal Structure of a computationally designed Immunogen S2_1.2 in complex with its elicited antibody C57 | Descriptor: | Antibody C57, Heavy Chain, Light Chain, ... | Authors: | Yang, C, Sesterhenn, F, Correia, B.E, Pojer, F. | Deposit date: | 2020-01-28 | Release date: | 2020-04-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.20116425 Å) | Cite: | De novo protein design enables the precise induction of RSV-neutralizing antibodies. Science, 368, 2020
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6YWD
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![BU of 6ywd by Molmil](/molmil-images/mine/6ywd) | De novo designed protein 4H_01 in complex with Mota antibody | Descriptor: | Antibody Mota, Heavy Chain, Light Chain, ... | Authors: | Yang, C, Sesterhenn, F, Pojer, F, Correia, B.E. | Deposit date: | 2020-04-29 | Release date: | 2020-10-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Bottom-up de novo design of functional proteins with complex structural features. Nat.Chem.Biol., 17, 2021
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6YWC
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![BU of 6ywc by Molmil](/molmil-images/mine/6ywc) | De novo designed protein 4E1H_95 in complex with 101F antibody | Descriptor: | Antibody 101F, Heavy Chain, light chain, ... | Authors: | Yang, C, Sesterhenn, F, Pojer, F, Correia, B.E. | Deposit date: | 2020-04-29 | Release date: | 2020-10-07 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Bottom-up de novo design of functional proteins with complex structural features. Nat.Chem.Biol., 17, 2021
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3J17
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![BU of 3j17 by Molmil](/molmil-images/mine/3j17) | Structure of a transcribing cypovirus by cryo-electron microscopy | Descriptor: | Structural protein VP3, Structural protein VP5, VP1 | Authors: | Yang, C, Ji, G, Liu, H, Zhang, K, Liu, G, Sun, F, Zhu, P, Cheng, L. | Deposit date: | 2011-12-25 | Release date: | 2012-04-04 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Cryo-EM structure of a transcribing cypovirus. Proc.Natl.Acad.Sci.USA, 109, 2012
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1TFZ
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![BU of 1tfz by Molmil](/molmil-images/mine/1tfz) | Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases | Descriptor: | (1-TERT-BUTYL-5-HYDROXY-1H-PYRAZOL-4-YL)[6-(METHYLSULFONYL)-4'-METHOXY-2-METHYL-1,1'-BIPHENYL-3-YL]METHANONE, 4-hydroxyphenylpyruvate dioxygenase, FE (III) ION | Authors: | Yang, C, Pflugrath, J.W, Camper, D.L, Foster, M.L, Pernich, D.J, Walsh, T.A. | Deposit date: | 2004-05-27 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and Mammalian 4-hydroxyphenylpyruvate dioxygenases Biochemistry, 43, 2004
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1SQD
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![BU of 1sqd by Molmil](/molmil-images/mine/1sqd) | Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases | Descriptor: | 4-hydroxyphenylpyruvate dioxygenase, FE (III) ION | Authors: | Yang, C, Pflugrath, J.W, Camper, D.L, Foster, M.L, Pernich, D.J, Walsh, T.A. | Deposit date: | 2004-03-18 | Release date: | 2004-08-17 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and Mammalian 4-hydroxyphenylpyruvate dioxygenases Biochemistry, 43, 2004
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1SQI
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![BU of 1sqi by Molmil](/molmil-images/mine/1sqi) | Structural basis for inhibitor selectivity revealed by crystal structures of plant and mammalian 4-hydroxyphenylpyruvate dioxygenases | Descriptor: | (1-TERT-BUTYL-5-HYDROXY-1H-PYRAZOL-4-YL)[6-(METHYLSULFONYL)-4'-METHOXY-2-METHYL-1,1'-BIPHENYL-3-YL]METHANONE, 4-hydroxyphenylpyruvic acid dioxygenase, FE (III) ION | Authors: | Yang, C, Pflugrath, J.W, Camper, D.L, Foster, M.L, Pernich, D.J, Walsh, T.A. | Deposit date: | 2004-03-18 | Release date: | 2004-08-17 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and Mammalian 4-hydroxyphenylpyruvate dioxygenases Biochemistry, 43, 2004
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1TG5
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![BU of 1tg5 by Molmil](/molmil-images/mine/1tg5) | Crystal structures of plant 4-hydroxyphenylpyruvate dioxygenases complexed with DAS645 | Descriptor: | 4-hydroxyphenylpyruvate dioxygenase, FE (II) ION, [1-TERT-BUTYL-3-(2,4-DICHLOROPHENYL)-5-HYDROXY-1H-PYRAZOL-4-YL][2-CHLORO-4-(METHYLSULFONYL)PHENYL]METHANONE | Authors: | Yang, C, Pflugrath, J.W, Camper, D.L, Foster, M.L, Pernich, D.J, Walsh, T.A. | Deposit date: | 2004-05-28 | Release date: | 2004-08-17 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis for herbicidal inhibitor selectivity revealed by comparison of crystal structures of plant and Mammalian 4-hydroxyphenylpyruvate dioxygenases Biochemistry, 43, 2004
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7CKK
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![BU of 7ckk by Molmil](/molmil-images/mine/7ckk) | Structural complex of FTO bound with Dac51 | Descriptor: | 2-{[2,6-dichloro-4-(3,5-dimethyl-1H-pyrazol-4-yl)phenyl]amino}-N-hydroxybenzamide, Alpha-ketoglutarate-dependent dioxygenase FTO, N-OXALYLGLYCINE | Authors: | Yang, C, Gan, J. | Deposit date: | 2020-07-17 | Release date: | 2021-07-21 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Tumors exploit FTO-mediated regulation of glycolytic metabolism to evade immune surveillance. Cell Metab., 33, 2021
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4JOX
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5Z4Y
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5Z50
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![BU of 5z50 by Molmil](/molmil-images/mine/5z50) | Crystal structure of PaCysB regulatory domain | Descriptor: | Cys regulon transcriptional activator, GLYCEROL, SULFATE ION | Authors: | Yang, C, Liang, H, Gan, J. | Deposit date: | 2018-01-15 | Release date: | 2019-01-23 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.206 Å) | Cite: | Molecular insights into the master regulator CysB-mediated bacterial virulence in Pseudomonas aeruginosa. Mol.Microbiol., 111, 2019
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5Z4Z
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4JP0
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7AYE
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![BU of 7aye by Molmil](/molmil-images/mine/7aye) | Crystal structure of the computationally designed chemically disruptable heterodimer LD6-MDM2 | Descriptor: | Isoform 11 of E3 ubiquitin-protein ligase Mdm2, Thiol:disulfide interchange protein DsbD | Authors: | Yang, C, Lau, K, Pojer, F, Correia, B.E. | Deposit date: | 2020-11-12 | Release date: | 2021-08-18 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (2.95 Å) | Cite: | A rational blueprint for the design of chemically-controlled protein switches. Nat Commun, 12, 2021
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5ZF2
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![BU of 5zf2 by Molmil](/molmil-images/mine/5zf2) | Crystal structure of Trxlp from Edwardsiella tarda EIB202 | Descriptor: | SULFATE ION, Thioredoxin (H-type,TRX-H) | Authors: | Yang, C, Quan, S. | Deposit date: | 2018-03-02 | Release date: | 2019-03-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.98 Å) | Cite: | The Edwardsiella piscicida thioredoxin-like protein inhibits ASK1-MAPKs signaling cascades to promote pathogenesis during infection. Plos Pathog., 15, 2019
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5ZYV
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5ZYW
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![BU of 5zyw by Molmil](/molmil-images/mine/5zyw) | The crystal structure of apo-HsMGME1 with Mn2+ | Descriptor: | GLYCEROL, L(+)-TARTARIC ACID, MANGANESE (II) ION, ... | Authors: | Yang, C, Gan, J. | Deposit date: | 2018-05-28 | Release date: | 2018-09-19 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural insights into DNA degradation by human mitochondrial nuclease MGME1 Nucleic Acids Res., 46, 2018
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5WYO
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![BU of 5wyo by Molmil](/molmil-images/mine/5wyo) | Solution structure of E.coli HdeA | Descriptor: | Acid stress chaperone HdeA | Authors: | Yang, C, Hu, Y, Jin, C. | Deposit date: | 2017-01-14 | Release date: | 2017-11-22 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Characterizations of the Interactions between Escherichia coli Periplasmic Chaperone HdeA and Its Native Substrates during Acid Stress Biochemistry, 56, 2017
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7ML0
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![BU of 7ml0 by Molmil](/molmil-images/mine/7ml0) | RNA polymerase II pre-initiation complex (PIC1) | Descriptor: | BJ4_G0050160.mRNA.1.CDS.1, DNA-directed RNA polymerase II subunit RPB11, DNA-directed RNA polymerase II subunit RPB3, ... | Authors: | Yang, C, Fujiwara, R, Kim, H.J, Gorbea Colon, J.J, Steimle, S, Garcia, B.A, Murakami, K. | Deposit date: | 2021-04-27 | Release date: | 2022-02-02 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structural visualization of de novo transcription initiation by Saccharomyces cerevisiae RNA polymerase II. Mol.Cell, 82, 2022
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