5WD7
 
 | | Structure of a bacterial polysialyltransferase in complex with fondaparinux | | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, SULFATE ION, SiaD | | 著者 | Worrall, L.J, Lizak, C, Strynadka, N.C.J. | | 登録日 | 2017-07-04 | | 公開日 | 2017-08-02 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | X-ray crystallographic structure of a bacterial polysialyltransferase provides insight into the biosynthesis of capsular polysialic acid.
Sci Rep, 7, 2017
|
|
5WCN
 | |
5TCP
 | | Near-atomic resolution cryo-EM structure of the periplasmic domains of PrgH and PrgK | | 分子名称: | Lipoprotein PrgK, Protein PrgH | | 著者 | Worrall, L.J, Hong, C, Vuckovic, M, Bergeron, J.R.C, Huang, R.K, Yu, Z, Strynadka, N.C.J. | | 登録日 | 2016-09-15 | | 公開日 | 2016-12-21 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | | 主引用文献 | Near-atomic-resolution cryo-EM analysis of the Salmonella T3S injectisome basal body.
Nature, 540, 2016
|
|
2P32
 | |
5CQB
 | | Crystal structure of E. coli undecaprenyl pyrophosphate synthase | | 分子名称: | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), TRIETHYLENE GLYCOL | | 著者 | Worrall, L.J, Conrady, D.G, Strynadka, N.C. | | 登録日 | 2015-07-21 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
5CQJ
 | | Crystal structure of E. coli undecaprenyl pyrophosphate synthase in complex with clomiphene | | 分子名称: | Clomifene, Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | | 著者 | Worrall, L.J, Conrady, D.G, Strynadka, N.C. | | 登録日 | 2015-07-21 | | 公開日 | 2015-08-19 | | 最終更新日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
3T07
 | | Crystal structure of S. aureus Pyruvate Kinase in complex with a naturally occurring bis-indole alkaloid | | 分子名称: | (3S,5R)-3,5-bis(6-bromo-1H-indol-3-yl)piperazin-2-one, PHOSPHATE ION, Pyruvate kinase | | 著者 | Worrall, L.J, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2011-07-19 | | 公開日 | 2011-10-26 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Methicillin-resistant Staphylococcus aureus (MRSA) pyruvate kinase as a target for bis-indole alkaloids with antibacterial activities.
J.Biol.Chem., 286, 2011
|
|
3T05
 | |
2X4A
 | |
2X49
 | | Crystal structure of the C-terminal domain of InvA | | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, INVASION PROTEIN INVA, ... | | 著者 | Worrall, L.J, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2010-01-28 | | 公開日 | 2010-03-31 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Crystal Structure of the C-Terminal Domain of the Salmonella Type III Secretion System Export Apparatus Protein Inva.
Protein Sci., 19, 2010
|
|
4X7R
 | | Crystal structure of S. aureus TarM G117R mutant in complex with Fondaparinux, alpha-GlcNAc-glycerol and UDP | | 分子名称: | (2S)-2,3-dihydroxypropyl 2-acetamido-2-deoxy-alpha-D-glucopyranoside, 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-beta-D-glucopyranuronic acid-(1-4)-2-deoxy-3,6-di-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranoside, TarM, ... | | 著者 | Worrall, L.J, Sobhanifar, S, Strynadka, N.C. | | 登録日 | 2014-12-09 | | 公開日 | 2015-02-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4X7P
 | | Crystal structure of apo S. aureus TarM | | 分子名称: | SULFATE ION, TarM | | 著者 | Worrall, L.J, Sobhanifar, S, Gruninger, R.J, Strynadka, N.C. | | 登録日 | 2014-12-09 | | 公開日 | 2015-02-18 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | | 主引用文献 | Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4X6L
 | | Crystal structure of S. aureus TarM in complex with UDP | | 分子名称: | TarM, URIDINE-5'-DIPHOSPHATE | | 著者 | Worrall, L.J, Sobhanifar, S, Gruninger, R.J, Strynadka, N.C. | | 登録日 | 2014-12-08 | | 公開日 | 2015-02-25 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (3.19 Å) | | 主引用文献 | Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
4X7M
 | | Crystal structure of S. aureus TarM G117R mutant in complex with UDP and UDP-GlcNAc | | 分子名称: | TarM, URIDINE-5'-DIPHOSPHATE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | | 著者 | Worrall, L.J, Sobhanifar, S, Strynadka, N.C. | | 登録日 | 2014-12-09 | | 公開日 | 2015-03-04 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure and mechanism of Staphylococcus aureus TarM, the wall teichoic acid alpha-glycosyltransferase.
Proc.Natl.Acad.Sci.USA, 112, 2015
|
|
8FFJ
 | | Structure of Zanidatamab bound to HER2 | | 分子名称: | Receptor tyrosine-protein kinase erbB-2, Zanidatamab Heavy Chain A, Zanidatamab Heavy Chain B, ... | | 著者 | Worrall, L.J, Atkinson, C.E, Sanches, M, Dixit, S, Strynadka, N.C.J. | | 登録日 | 2022-12-08 | | 公開日 | 2023-02-22 | | 最終更新日 | 2024-09-04 | | 実験手法 | ELECTRON MICROSCOPY (7.5 Å) | | 主引用文献 | An anti-HER2 biparatopic antibody that induces unique HER2 clustering and complement-dependent cytotoxicity.
Nat Commun, 14, 2023
|
|
8EXP
 | | Cryo-EM structure of S. aureus BlaR1 with C2 symmetry | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
|
|
8EXR
 | | Cryo-EM structure of S. aureus BlaR1 TM and zinc metalloprotease domain | | 分子名称: | (2S)-3-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-2-[(6E)-HEXADEC-6-ENOYLOXY]PROPYL (8E)-OCTADEC-8-ENOATE, Beta-lactam sensor/signal transducer BlaR1, PHOSPHATE ION, ... | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
|
|
8EXQ
 | | Cryo-EM structure of S. aureus BlaR1 with C1 symmetry | | 分子名称: | Beta-lactam sensor/signal transducer BlaR1, ZINC ION | | 著者 | Worrall, L.J, Alexander, J.A.N, Vuckovic, M, Strynadka, N.C.J. | | 登録日 | 2022-10-25 | | 公開日 | 2023-01-11 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structural basis of broad-spectrum beta-lactam resistance in Staphylococcus aureus.
Nature, 613, 2023
|
|
8SXR
 | | Crystal structure of SARS-CoV-2 Mpro with C5a | | 分子名称: | 3C-like proteinase nsp5, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(5-hydroxyisoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Kenward, C, Lee, J, Strynadka, N.C.J. | | 登録日 | 2023-05-23 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.114 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
|
|
4G2S
 | |
8CZ7
 | | Crystal structure of SARS-CoV-2 Mpro with compound C2 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-(4-methoxyphenyl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
|
|
8CYU
 | | Crystal structure of SARS-CoV-2 Mpro with compound C5 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-N-[4-(dimethylamino)phenyl]-2-(isoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
|
|
8CZ4
 | | Crystal structure of SARS-CoV-2 Mpro with compound C3 | | 分子名称: | 3C-like proteinase, N-(4-tert-butylphenyl)-N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
|
|
8CYZ
 | | Crystal structure of SARS-CoV-2 Mpro with compound C4 | | 分子名称: | 3C-like proteinase, N-[(4-chlorothiophen-2-yl)methyl]-2-(isoquinolin-4-yl)-N-[4-(methylsulfanyl)phenyl]acetamide | | 著者 | Worrall, L.J, Lee, J, Strynadka, N.C.J. | | 登録日 | 2022-05-24 | | 公開日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | A novel class of broad-spectrum active-site-directed 3C-like protease inhibitors with nanomolar antiviral activity against highly immune-evasive SARS-CoV-2 Omicron subvariants.
Emerg Microbes Infect, 12, 2023
|
|
6XCI
 | | Structure of NDM-1 in complex with macrocycle inhibitor NDM1i-3D | | 分子名称: | ACETATE ION, BlaNDM-4_1_JQ348841, CADMIUM ION, ... | | 著者 | Worrall, L.J, Sun, T, Mulligan, V.K, Strynadka, N.C.J. | | 登録日 | 2020-06-08 | | 公開日 | 2021-03-31 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Computationally designed peptide macrocycle inhibitors of New Delhi metallo-beta-lactamase 1.
Proc.Natl.Acad.Sci.USA, 118, 2021
|
|
