5CQJ
Crystal structure of E. coli undecaprenyl pyrophosphate synthase in complex with clomiphene
Summary for 5CQJ
Entry DOI | 10.2210/pdb5cqj/pdb |
Related | 5CQB |
Descriptor | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific), Clomifene (3 entities in total) |
Functional Keywords | transferase, cell wall, wall teichoic acid, antibacterial, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Escherichia coli (strain K12) |
Total number of polymer chains | 2 |
Total formula weight | 57368.21 |
Authors | Worrall, L.J.,Conrady, D.G.,Strynadka, N.C. (deposition date: 2015-07-21, release date: 2015-08-19, Last modification date: 2024-03-06) |
Primary citation | Farha, M.A.,Czarny, T.L.,Myers, C.L.,Worrall, L.J.,French, S.,Conrady, D.G.,Wang, Y.,Oldfield, E.,Strynadka, N.C.,Brown, E.D. Antagonism screen for inhibitors of bacterial cell wall biogenesis uncovers an inhibitor of undecaprenyl diphosphate synthase. Proc.Natl.Acad.Sci.USA, 112:11048-11053, 2015 Cited by PubMed: 26283394DOI: 10.1073/pnas.1511751112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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