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PDB: 275 件
4H8G
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crystal structure of a parallel 6-helix coiled coil CC-Hex-IL- 22
分子名称: CC-Hex-IL-22
著者Chi, B, Zaccai, N.R, Brady, R.L, Woolfson, D.N.
登録日2012-09-22
公開日2014-02-05
実験手法X-RAY DIFFRACTION (1.699 Å)
主引用文献TBA
J.Am.Chem.Soc.
1ZIK
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BU of 1zik by Molmil
GCN4-LEUCINE ZIPPER CORE MUTANT ASN16LYS IN THE DIMERIC STATE
分子名称: GENERAL CONTROL PROTEIN GCN4
著者Gonzalez Junior, L, Woolfson, D.N, Alber, T.
登録日1996-10-30
公開日1997-07-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Buried polar residues and structural specificity in the GCN4 leucine zipper.
Nat.Struct.Biol., 3, 1996
4H8L
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Crystal structure of a parallel 6-helix coiled coil CC-Hex-D24-A5/7C
分子名称: CC-Hex-D24-A5/7C
著者Chi, B, Zaccai, N.R, Brady, R.L, Woolfson, D.N.
登録日2012-09-23
公開日2014-02-05
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.7501 Å)
主引用文献TBA
J.Am.Chem.Soc.
4HI8
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Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
分子名称: Integrin-linked protein kinase, LIM and senescent cell antigen-like-containing domain protein 1, PHOSPHATE ION, ...
著者Stiegler, A.L, Jakoncic, J, Stojanoff, V, Chiswell, B.P, Calderwood, D.A, Boggon, T.J.
登録日2012-10-11
公開日2013-12-11
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.203 Å)
主引用文献Structure of integrin-linked kinase ankyrin repeat domain in complex with PINCH1 LIM1 domain collected at high energy, wavelength 0.32800
To be Published
4BBK
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Structural and functional characterisation of the kindlin-1 pleckstrin homology domain
分子名称: FERMITIN FAMILY HOMOLOG 1, GLYCEROL
著者Yates, L.A, Lumb, C.N, Brahme, N.N, Zalyte, R, Bird, L.E, De Colibus, L, Owens, R.J, Calderwood, D.A, Sansom, M.S.P, Gilbert, R.J.C.
登録日2012-09-25
公開日2012-11-14
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural and Functional Characterisation of the Kindlin-1 Pleckstrin Homology Domain
J.Biol.Chem., 287, 2012
4DX8
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ICAP1 in complex with KRIT1 N-terminus
分子名称: BROMIDE ION, Integrin beta-1-binding protein 1, Krev interaction trapped protein 1
著者Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J.
登録日2012-02-27
公開日2013-01-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
5EZ8
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A de novo designed heptameric coiled coil CC-Hept-I-C-I
分子名称: CC-Hept-I-C-I
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
4DZN
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A de novo designed Coiled Coil CC-pIL
分子名称: COILED-COIL PEPTIDE CC-PIL
著者Bruning, M, Thomson, A.R, Zaccai, N.R, Brady, R.L, Woolfson, D.N.
登録日2012-03-01
公開日2012-08-29
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.59 Å)
主引用文献A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology.
ACS Synth Biol, 1, 2012
5EZC
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A de novo designed heptameric coiled coil CC-Hept-I18C-L22H-I25E
分子名称: CC-Hept-C-H-E
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
5F2Y
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A de novo designed heptameric coiled coil CC-Hept-homoCys-H-E
分子名称: CC-Hept-hCys-H-E
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-12-02
公開日2016-07-06
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
4DZM
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BU of 4dzm by Molmil
A de novo designed Coiled Coil CC-Di
分子名称: COILED-COIL PEPTIDE CC-DI
著者Bruning, M, Thomson, A.R, Zaccai, N.R, Brady, R.L, Woolfson, D.N.
登録日2012-03-01
公開日2012-08-29
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (1.94 Å)
主引用文献A basis set of de novo coiled-coil Peptide oligomers for rational protein design and synthetic biology.
ACS Synth Biol, 1, 2012
4H8O
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BU of 4h8o by Molmil
Crystal structure of a parallel 6-helix coiled coil CC-Hex-N24
分子名称: CC-Hex-N24
著者Chi, B, Zaccai, N.R, Brady, R.L, Woolfson, D.N.
登録日2012-09-23
公開日2014-02-05
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.598 Å)
主引用文献TBA
To be Published
4H7R
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BU of 4h7r by Molmil
Crystal structure of a parallel 4-helix coiled coil CC-Hex-II
分子名称: 1,4-DIETHYLENE DIOXIDE, CC-Hex-II, GLYCEROL
著者Chi, B, Zaccai, N.R, Brady, R.L, Woolfson, D.N.
登録日2012-09-20
公開日2014-02-05
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献TBA
To be Published
4A1O
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BU of 4a1o by Molmil
Crystal structure of Mycobacterium tuberculosis PurH complexed with AICAR and a novel nucleotide CFAIR, at 2.48 A resolution.
分子名称: 5-(FORMYLAMINO)-1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1H-IMIDAZOLE-4-CARBOXYLIC ACID, AMINOIMIDAZOLE 4-CARBOXAMIDE RIBONUCLEOTIDE, BIFUNCTIONAL PURINE BIOSYNTHESIS PROTEIN PURH, ...
著者Le Nours, J, Bulloch, E.M.M, Zhang, Z, Greenwood, D.R, Middleditch, M.J, Dickson, J.M.J, Baker, E.N.
登録日2011-09-17
公開日2011-09-28
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.48 Å)
主引用文献Structural Analyses of a Purine Biosynthetic Enzyme from Mycobacterium Tuberculosis Reveal a Novel Bound Nucleotide.
J.Biol.Chem., 286, 2011
5A0E
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BU of 5a0e by Molmil
Crystal structure of cyclophilin D in complex with CsA analogue, JW47.
分子名称: JW47, PEPTIDYL-PROLYL CIS-TRANS ISOMERASE F, MITOCHONDRIAL
著者Warne, J, Pryce, G, Hill, J, Shi, X, Lenneras, F, Puentes, F, Kip, M, Hilditch, L, Walker, P, Simone, M, Chan, A.W.E, Towers, G, Coker, A.R, Duchen, M, Szabadkai, G, Baker, D, Selwood, D.L.
登録日2015-04-19
公開日2015-12-30
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.25 Å)
主引用文献Selective Inhibition of the Mitochondrial Permeability Transition Pore Protects Against Neuro-Degeneration in Experimental Multiple Sclerosis.
J.Biol.Chem., 291, 2016
4EDL
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BU of 4edl by Molmil
Crystal structure of beta-parvin CH2 domain
分子名称: 1,2-ETHANEDIOL, Beta-parvin
著者Stiegler, A.L, Draheim, K.M, Li, X, Chayen, N.E, Calderwood, D.A, Boggon, T.J.
登録日2012-03-27
公開日2012-08-08
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for paxillin binding and focal adhesion targeting of beta-parvin.
J.Biol.Chem., 287, 2012
5EZA
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BU of 5eza by Molmil
A de novo designed heptameric coiled coil CC-Hept-I18C-L22H
分子名称: CC-Hept-C-H-I, GLYCEROL
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
5EZ9
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BU of 5ez9 by Molmil
A de novo designed heptameric coiled coil CC-Hept-I-H-I
分子名称: CC-Hept-L22H, HEXANE-1,6-DIOL
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
4DX9
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BU of 4dx9 by Molmil
ICAP1 in complex with integrin beta 1 cytoplasmic tail
分子名称: Integrin beta-1, Integrin beta-1-binding protein 1
著者Liu, W, Draheim, K, Zhang, R, Calderwood, D.A, Boggon, T.J.
登録日2012-02-27
公開日2013-01-09
最終更新日2020-09-02
実験手法X-RAY DIFFRACTION (2.99 Å)
主引用文献Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation.
Mol.Cell, 49, 2013
2C0O
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BU of 2c0o by Molmil
Src family kinase Hck with bound inhibitor A-770041
分子名称: CALCIUM ION, N-(4-{1-[4-(4-ACETYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-4-AMINO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK
著者Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A.
登録日2005-09-06
公開日2006-09-20
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
Bioorg.Med.Chem.Lett., 16, 2006
2C0T
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BU of 2c0t by Molmil
Src family kinase Hck with bound inhibitor A-641359
分子名称: CALCIUM ION, N-(4-{4-AMINO-1-[1-(TETRAHYDRO-2H-PYRAN-4-YL)PIPERIDIN-4-YL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK
著者Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A.
登録日2005-09-07
公開日2006-09-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
Bioorg.Med.Chem.Lett., 16, 2006
2C0I
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Src family kinase Hck with bound inhibitor A-420983
分子名称: CALCIUM ION, N-(4-{4-AMINO-1-[4-(4-METHYLPIPERAZIN-1-YL)-TRANS-CYCLOHEXYL]-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL}-2-METHOXYPHENYL)-1-METHYL-1H-INDOLE-2-CARBOXAMIDE, TYROSINE-PROTEIN KINASE HCK
著者Borhani, D.W, Burchat, A, Calderwood, D.J, Hirst, G.C, Li, B, Loew, A.
登録日2005-09-03
公開日2006-09-20
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of A-770041, a Src-Family Selective Orally Active Lck Inhibitor that Prevents Organ Allograft Rejection.
Bioorg.Med.Chem.Lett., 16, 2006
5EZE
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A de novo designed heptameric coiled coil CC-Hept-I18betaMeCys-L22H-I25E
分子名称: CC-Hept-bMeCys-His-Glu, GLYCEROL
著者Burton, A.J, Brady, R.L, Woolfson, D.N.
登録日2015-11-26
公開日2016-07-06
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Installing hydrolytic activity into a completely de novo protein framework.
Nat.Chem., 8, 2016
1EYM
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BU of 1eym by Molmil
FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX
分子名称: FK506 BINDING PROTEIN
著者Rollins, C.T, Rivera, V.M, Woolfson, D.N, Keenan, T, Hatada, M, Adams, S.E, Andrade, L.J, Yaeger, D, van Schravendijk, M.R, Holt, D.A, Gilman, M, Clackson, T.
登録日2000-05-07
公開日2000-08-09
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A ligand-reversible dimerization system for controlling protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 97, 2000
2IQG
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Crystal Structure of Hydroxyethyl Secondary Amine-based Peptidomimetic Inhibitor of Human Beta-Secretase (BACE)
分子名称: Beta-secretase 1, N'-{(1S,2R)-1-(3,5-DIFLUOROBENZYL)-2-HYDROXY-3-[(3-IODOBENZYL)AMINO]PROPYL}-5-METHYL-N,N-DIPROPYLISOPHTHALAMIDE
著者Benson, T.E, Woods, D.D, Prince, D.B, Tomasselli, A.G, Emmons, T.L.
登録日2006-10-13
公開日2007-02-27
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Design, Synthesis, and Crystal Structure of Hydroxyethyl Secondary Amine-Based Peptidomimetic Inhibitors of Human beta-Secretase.
J.Med.Chem., 50, 2007

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