4O9M
| Human DNA polymerase beta complexed with adenylated tetrahydrofuran (abasic site) containing DNA | 分子名称: | (5'-D(P*GP*TP*CP*GP*G)-3');, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ... | 著者 | Caglayan, M, Batra, V.K, Sassa, A, Prasad, R, Wilson, S.H. | 登録日 | 2014-01-02 | 公開日 | 2014-04-30 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | 主引用文献 | Role of polymerase beta in complementing aprataxin deficiency during abasic-site base excision repair. Nat.Struct.Mol.Biol., 21, 2014
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4GXJ
| R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dCTP analog | 分子名称: | 2'-deoxy-5'-O-[(S)-{difluoro[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}(hydroxy)phosphoryl]cytidine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | 登録日 | 2012-09-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Res., 41, 2013
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4GXK
| R283K DNA polymerase beta ternary complex with a templating 8OG and incoming dATP analog | 分子名称: | 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonooxy)phosphoryl]methyl}phosphoryl]adenosine, DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), ... | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | 登録日 | 2012-09-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.998 Å) | 主引用文献 | DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Res., 41, 2013
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4R66
| Ternary complex crystal structure of E295K mutant of DNA polymerase Beta | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Beard, W.A, Wilson, S.H. | 登録日 | 2014-08-22 | 公開日 | 2014-10-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Substrate-induced DNA Polymerase beta Activation. J.Biol.Chem., 289, 2014
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4GXI
| R283K DNA polymerase beta binary complex with a templating 8OG | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*(8OG)P*TP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*A)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Freudenthal, B.D, Beard, W.A, Wilson, S.H. | 登録日 | 2012-09-04 | 公開日 | 2013-01-16 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.949 Å) | 主引用文献 | DNA polymerase minor groove interactions modulate mutagenic bypass of a templating 8-oxoguanine lesion. Nucleic Acids Res., 41, 2013
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4R63
| Binary complex crystal structure of R258A mutant of DNA polymerase Beta | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Batra, V.K, Beard, W.A, Wilson, S.H. | 登録日 | 2014-08-22 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Substrate-induced DNA Polymerase beta Activation. J.Biol.Chem., 289, 2014
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4R65
| Ternary complex crystal structure of R258A mutant of DNA polymerase Beta | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Beard, W.A, Wilson, S.H. | 登録日 | 2014-08-22 | 公開日 | 2014-10-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Substrate-induced DNA Polymerase beta Activation. J.Biol.Chem., 289, 2014
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4RT3
| Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP | 分子名称: | 2'-deoxy-5'-O-[(S)-hydroxy{[(R)-hydroxy(phosphonomethyl)phosphoryl]amino}phosphoryl]-3,4-dihydrothymidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Wilson, S.H. | 登録日 | 2014-11-12 | 公開日 | 2015-07-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Two Scaffolds from Two Flips: (alpha, beta)/(beta, gamma) CH2/NH "Met-Im" Analogues of dTTP. Org.Lett., 17, 2015
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4RT2
| Ternary complex crystal structure of DNA polymerase Beta with (alpha,beta)-CH2-(beta,gamma)-NH-dTTP | 分子名称: | 2'-deoxy-5'-O-[(S)-hydroxy{[(S)-hydroxy(phosphonoamino)phosphoryl]methyl}phosphoryl]-3,4-dihydrothymidine, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Wilson, S.H. | 登録日 | 2014-11-12 | 公開日 | 2015-07-01 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Two Scaffolds from Two Flips: (alpha, beta)/(beta, gamma) CH2/NH "Met-Im" Analogues of dTTP. Org.Lett., 17, 2015
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4R64
| Binary complex crystal structure of E295K mutant of DNA polymerase Beta | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Batra, V.K, Beard, W.A, Wilson, S.H. | 登録日 | 2014-08-22 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Substrate-induced DNA Polymerase beta Activation. J.Biol.Chem., 289, 2014
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4JWM
| Ternary complex of D256E mutant of DNA Polymerase Beta | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Perera, L, Ping, L, Shock, D.D, Beard, W.A, Pedersen, L.C, Pedersen, L.G, Wilson, S.H. | 登録日 | 2013-03-27 | 公開日 | 2013-06-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Amino Acid Substitution in the Active Site of DNA Polymerase beta Explains the Energy Barrier of the Nucleotidyl Transfer Reaction. J.Am.Chem.Soc., 135, 2013
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4UBC
| DNA polymerase beta substrate complex with a templating cytosine and incoming 8-oxodGTP, 0 s | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Wilson, S.H, Beard, W.A. | 登録日 | 2014-08-12 | 公開日 | 2014-11-12 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature, 517, 2015
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4GFJ
| Crystal structure of Topo-78, an N-terminal 78kDa fragment of topoisomerase V | 分子名称: | GLYCEROL, Topoisomerase V, ZINC ION | 著者 | Rajan, R, Prasad, R, Taneja, B, Wilson, S.H, Mondragon, A. | 登録日 | 2012-08-03 | 公開日 | 2012-12-05 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.91 Å) | 主引用文献 | Identification of one of the apurinic/apyrimidinic lyase active sites of topoisomerase V by structural and functional studies. Nucleic Acids Res., 41, 2013
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4JWN
| Ternary complex of D256A mutant of DNA Polymerase Beta | 分子名称: | 2'-DEOXYURIDINE 5'-ALPHA,BETA-IMIDO-TRIPHOSPHATE, CHLORIDE ION, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ... | 著者 | Batra, V.K, Perera, L, Ping, L, Shock, D.D, Beard, W.A, Pedersen, L.C, Pedersen, L.G, Wilson, S.H. | 登録日 | 2013-03-27 | 公開日 | 2013-06-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Amino Acid Substitution in the Active Site of DNA Polymerase beta Explains the Energy Barrier of the Nucleotidyl Transfer Reaction. J.Am.Chem.Soc., 135, 2013
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4KLH
| DNA polymerase beta matched product complex with Mn2+, 40 s | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H. | 登録日 | 2013-05-07 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.876 Å) | 主引用文献 | Observing a DNA polymerase choose right from wrong. Cell(Cambridge,Mass.), 154, 2013
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4KLT
| DNA polymerase beta mismatched product complex with Mn2+, 30 min | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H. | 登録日 | 2013-05-07 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.979 Å) | 主引用文献 | Observing a DNA polymerase choose right from wrong. Cell(Cambridge,Mass.), 154, 2013
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4KLL
| DNA polymerase beta matched product complex with Mg2+, 45 min | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H. | 登録日 | 2013-05-07 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.841 Å) | 主引用文献 | Observing a DNA polymerase choose right from wrong. Cell(Cambridge,Mass.), 154, 2013
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4KLU
| DNA polymerase beta mismatched product complex with Mn2+, 15 h | 分子名称: | 5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*A)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | 著者 | Freudenthal, B.D, Beard, W.A, Shock, D.D, Wilson, S.H. | 登録日 | 2013-05-07 | 公開日 | 2013-07-17 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.97 Å) | 主引用文献 | Observing a DNA polymerase choose right from wrong. Cell(Cambridge,Mass.), 154, 2013
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5TYE
| DNA Polymerase Mu Product Complex, 10 mM Mg2+ (60 min) | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2016-11-19 | 公開日 | 2017-08-30 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.047 Å) | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5U9H
| DNA polymerase beta product complex with inserted Sp-isomer of dCTP-alpha-S | 分子名称: | DNA (5'-D(*CP*CP*GP*AP*CP*GP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*(C7R))-3'), DNA (5'-D(P*GP*TP*CP*GP*G)-3'), ... | 著者 | Freudenthal, B.D, Wilson, S.H, Beard, W.A. | 登録日 | 2016-12-16 | 公開日 | 2017-02-08 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Revealing the role of the product metal in DNA polymerase beta catalysis. Nucleic Acids Res., 45, 2017
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5TYG
| DNA Polymerase Mu Product Complex, 10 mM Mg2+ (960 min) | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2016-11-19 | 公開日 | 2017-08-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.726 Å) | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TYU
| DNA Polymerase Mu Reactant Complex, Mn2+ (4 min) | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2016-11-21 | 公開日 | 2017-08-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.048 Å) | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TXZ
| DNA Polymerase Mu Reactant Complex, 100mM Mg2+ (15 min) | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2016-11-17 | 公開日 | 2017-08-30 | 実験手法 | X-RAY DIFFRACTION (1.651 Å) | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TYD
| DNA Polymerase Mu Reactant Complex, 10 mM Mg2+ (45 min) | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2016-11-19 | 公開日 | 2017-08-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.899 Å) | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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5TXX
| DNA Polymerase Mu Pre-Catalytic Ground State Ternary Complex, Ca2+ | 分子名称: | 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2016-11-17 | 公開日 | 2017-08-30 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.948 Å) | 主引用文献 | Time-lapse crystallography snapshots of a double-strand break repair polymerase in action. Nat Commun, 8, 2017
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