4RT3

Ternary complex crystal structure of DNA polymerase Beta with (alpha, beta)-NH-(beta,gamma)-CH2-dTTP

Summary for 4RT3

Related4RT2
DescriptorDNA polymerase beta, DNA (5'-D(*CP*CP*GP*AP*CP*AP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*(DOC))-3'), ... (9 entities in total)
Functional Keywordsdna polymerase beta, ternary complex, transferase-dna complex, transferase/dna
Biological sourceHomo sapiens (human)
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Cellular locationNucleus P06746
Total number of polymer chains4
Total molecular weight48354.72
Authors
Batra, V.K.,Wilson, S.H. (deposition date: 2014-11-12, release date: 2015-07-01)
Primary citation
Kadina, A.P.,Kashemirov, B.A.,Oertell, K.,Batra, V.K.,Wilson, S.H.,Goodman, M.F.,McKenna, C.E.
Two Scaffolds from Two Flips: (alpha, beta)/(beta, gamma) CH2/NH "Met-Im" Analogues of dTTP.
Org.Lett., 17:2586-2589, 2015
PubMed: 25970636 (PDB entries with the same primary citation)
DOI: 10.1021/acs.orglett.5b00799
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.92 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.226300.7%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution