Loading
PDBj
MenuPDBj@FacebookPDBj@X(formerly Twitter)PDBj@BlueSkyPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 255 results

2UZI
DownloadVisualize
BU of 2uzi by Molmil
Crystal structure of HRAS(G12V) - anti-RAS Fv complex
Descriptor: ANTI-RAS FV HEAVY CHAIN, ANTI-RAS FV LIGHT CHAIN, GTPASE HRAS, ...
Authors:Tanaka, T, williams, R.L, Rabbitts, T.H.
Deposit date:2007-04-27
Release date:2007-06-26
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Tumour Prevention by a Single Antibody Domain Targeting the Interaction of Signal Transduction Proteins with Ras.
Embo J., 26, 2007
2X6I
DownloadVisualize
BU of 2x6i by Molmil
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-90
Descriptor: N-(2,3-DIHYDRO-7,8-DIMETHOXYIMIDAZO[1,2-C] QUINAZOLIN-5-YL)NICOTINAMIDE, PHOSPHOTIDYLINOSITOL 3 KINASE 59F
Authors:Miller, S, Tavshanjian, B, Oleksy, A, Perisic, O, Houseman, B.T, Shokat, K.M, Williams, R.L.
Deposit date:2010-02-17
Release date:2010-04-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.4 Å)
Cite:Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327, 2010
2V14
DownloadVisualize
BU of 2v14 by Molmil
Kinesin 16B Phox-homology domain (KIF16B)
Descriptor: KINESIN-LIKE MOTOR PROTEIN C20ORF23
Authors:Wilson, M.I, Williams, R.L, Cho, W, Hong, W, Blatner, N.R.
Deposit date:2007-05-21
Release date:2007-07-31
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Structural Basis of Novel Endosome Anchoring Activity of Kif16B Kinesin.
Embo J., 26, 2007
2V1Y
DownloadVisualize
BU of 2v1y by Molmil
Structure of a phosphoinositide 3-kinase alpha adaptor-binding domain (ABD) in a complex with the iSH2 domain from p85 alpha
Descriptor: PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT ALPHA ISOFORM
Authors:Miled, N, Yan, Y, Hon, W.C, Perisic, O, Zvelebil, M, Inbar, Y, Schneidman-Duhovny, D, Wolfson, H.J, Backer, J.M, Williams, R.L.
Deposit date:2007-05-30
Release date:2007-07-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Mechanism of Two Classes of Cancer Mutations in the Phosphoinositide 3-Kinase Catalytic Subunit.
Science, 317, 2007
2W2U
DownloadVisualize
BU of 2w2u by Molmil
STRUCTURAL INSIGHT INTO THE INTERACTION BETWEEN ARCHAEAL ESCRT-III AND AAA-ATPASE
Descriptor: CONSERVED ARCHAEAL PROTEIN, HYPOTHETICAL P60 KATANIN
Authors:Obita, T, Samson, R.Y, Perisic, O, Freund, S.M, Bell, S.D, Williams, R.L.
Deposit date:2008-11-04
Release date:2009-07-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:A Role for the Escrt System in Cell Division in Archaea.
Science, 322, 2008
2V4L
DownloadVisualize
BU of 2v4l by Molmil
complex of human phosphoinositide 3-kinase catalytic subunit gamma (p110 gamma) with PIK-284
Descriptor: 3-[4-AMINO-1-(1-METHYLETHYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL]PHENOL, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM
Authors:Apsel, B, Gonzalez, B, Blair, J.A, Nazif, T.M, Feldman, M.E, Williams, R.L, Shokat, K.M, Knight, Z.A.
Deposit date:2008-09-25
Release date:2008-10-14
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Targeted Polypharmacology: Discovery of Dual Inhibitors of Tyrosine and Phosphoinositide Kinases.
Nat.Chem.Biol., 4, 2008
2X6H
DownloadVisualize
BU of 2x6h by Molmil
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34
Descriptor: PHOSPHOTIDYLINOSITOL 3 KINASE 59F
Authors:Miller, S, Tavshanjian, B, Oleksy, A, Perisic, O, Houseman, B.T, Shokat, K.M, Williams, R.L.
Deposit date:2010-02-17
Release date:2010-04-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327, 2010
2X6F
DownloadVisualize
BU of 2x6f by Molmil
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH 3-METHYLADENINE
Descriptor: 6-AMINO-3-METHYLPURINE, PHOSPHOTIDYLINOSITOL 3 KINASE 59F
Authors:Miller, S, Tavshanjian, B, Oleksy, A, Perisic, O, Houseman, B.T, Shokat, K.M, Williams, R.L.
Deposit date:2010-02-17
Release date:2010-04-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327, 2010
2X6J
DownloadVisualize
BU of 2x6j by Molmil
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PIK-93
Descriptor: N-(5-(4-CHLORO-3-(2-HYDROXY-ETHYLSULFAMOYL)- PHENYLTHIAZOLE-2-YL)-ACETAMIDE, PHOSPHOTIDYLINOSITOL 3 KINASE 59F
Authors:Miller, S, Tavshanjian, B, Oleksy, A, Perisic, O, Houseman, B.T, Shokat, K.M, Williams, R.L.
Deposit date:2010-02-17
Release date:2010-04-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327, 2010
2X6K
DownloadVisualize
BU of 2x6k by Molmil
THE CRYSTAL STRUCTURE OF THE DROSOPHILA CLASS III PI3-KINASE VPS34 IN COMPLEX WITH PI-103
Descriptor: 3-(4-MORPHOLIN-4-YLPYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDIN-2-YL)PHENOL, PHOSPHOTIDYLINOSITOL 3 KINASE 59F, SULFATE ION
Authors:Miller, S, Tavshanjian, B, Oleksy, A, Perisic, O, Houseman, B.T, Shokat, K.M, Williams, R.L.
Deposit date:2010-02-17
Release date:2010-04-07
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.5 Å)
Cite:Shaping Development of Autophagy Inhibitors with the Structure of the Lipid Kinase Vps34.
Science, 327, 2010
2V6V
DownloadVisualize
BU of 2v6v by Molmil
The structure of the Bem1p PX domain
Descriptor: 2,3-DIHYDROXY-1,4-DITHIOBUTANE, BUD EMERGENCE PROTEIN 1
Authors:Stahelin, R.V, Karathanassis, D, Murray, D, Williams, R.L, Cho, W.
Deposit date:2007-07-21
Release date:2007-07-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural and Membrane Binding Analysis of the Phox Homology Domain of Bem1P: Basis of Phosphatidylinositol 4-Phosphate Specificity.
J.Biol.Chem., 282, 2007
2Y3A
DownloadVisualize
BU of 2y3a by Molmil
Crystal structure of p110beta in complex with icSH2 of p85beta and the drug GDC-0941
Descriptor: 2-(1H-indazol-4-yl)-6-{[4-(methylsulfonyl)piperazin-1-yl]methyl}-4-morpholin-4-yl-thieno[3,2-d]pyrimidine, PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT BETA, PHOSPHATIDYLINOSITOL-4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT BETA ISOFORM
Authors:Zhang, X, Vadas, O, Perisic, O, Williams, R.L.
Deposit date:2010-12-20
Release date:2011-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (3.3 Å)
Cite:Structure of Lipid Kinase P110Beta-P85Beta Elucidates an Unusual Sh2-Domain-Mediated Inhibitory Mechanism.
Mol.Cell, 41, 2011
5NGB
DownloadVisualize
BU of 5ngb by Molmil
X-Ray Diffraction Crystal Structure of the murine PI3K p110delta in complex with a pan inhibitor
Descriptor: 3-[[4-(2-morpholin-4-yl-4-oxidanylidene-3~{H}-quinolin-8-yl)-1,2,3-triazol-1-yl]methyl]benzoic acid, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
Authors:Berndt, A, Williams, R.L.
Deposit date:2017-03-17
Release date:2017-09-13
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Identification of a Potent Phosphoinositide 3-Kinase Pan Inhibitor Displaying a Strategic Carboxylic Acid Group and Development of Its Prodrugs.
ChemMedChem, 12, 2017
2VH5
DownloadVisualize
BU of 2vh5 by Molmil
CRYSTAL STRUCTURE OF HRAS(G12V) - ANTI-RAS FV (disulfide free mutant) COMPLEX
Descriptor: ANTI-RAS FV HEAVY CHAIN, ANTI-RAS FV LIGHT CHAIN, GTPASE HRAS, ...
Authors:Tanaka, T, Williams, R.L, Rabbitts, T.H.
Deposit date:2007-11-19
Release date:2008-01-22
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Functional Intracellular Antibody Fragments Do not Require Invariant Intra-Domain Disulfide Bonds.
J.Mol.Biol., 376, 2008
5NP1
DownloadVisualize
BU of 5np1 by Molmil
Open protomer of human ATM (Ataxia telangiectasia mutated)
Descriptor: Serine-protein kinase ATM
Authors:Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L.
Deposit date:2017-04-13
Release date:2017-05-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
5NP0
DownloadVisualize
BU of 5np0 by Molmil
Closed dimer of human ATM (Ataxia telangiectasia mutated)
Descriptor: Serine-protein kinase ATM
Authors:Baretic, D, Pollard, H.K, Fisher, D.I, Johnson, C.M, Santhanam, B, Truman, C.M, Kouba, T, Fersht, A.R, Phillips, C, Williams, R.L.
Deposit date:2017-04-13
Release date:2017-05-17
Last modified:2024-05-15
Method:ELECTRON MICROSCOPY (5.7 Å)
Cite:Structures of closed and open conformations of dimeric human ATM.
Sci Adv, 3, 2017
7KR3
DownloadVisualize
BU of 7kr3 by Molmil
Human DNA Ligase 1(E346A/E592A) Bound to a bulged DNA substrate
Descriptor: ACETATE ION, ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*CP*C)-3'), ...
Authors:Tumbale, P.P, Williams, R.S.
Deposit date:2020-11-18
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.778 Å)
Cite:High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.
Nat Commun, 12, 2021
7KR4
DownloadVisualize
BU of 7kr4 by Molmil
Human DNA Ligase 1(E346A/E592A) Bound to a nicked DNA substrate control duplex
Descriptor: ACETATE ION, ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*AP*TP*GP*TP*CP*TP*GP*CP*CP*C)-3'), ...
Authors:Tumbale, P.P, Williams, R.S.
Deposit date:2020-11-18
Release date:2021-02-03
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:High-fidelity DNA ligation enforces accurate Okazaki fragment maturation during DNA replication.
Nat Commun, 12, 2021
7JL5
DownloadVisualize
BU of 7jl5 by Molmil
Crystal structure of human NEIL3 tandem zinc finger GRF domains
Descriptor: Endonuclease 8-like 3, ZINC ION
Authors:Rodriguez, A.A, Wojtaszek, J.L, Williams, R.S, Eichman, B.F.
Deposit date:2020-07-29
Release date:2020-09-09
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:An autoinhibitory role for the GRF zinc finger domain of DNA glycosylase NEIL3.
J.Biol.Chem., 295, 2020
7L34
DownloadVisualize
BU of 7l34 by Molmil
Human DNA Ligase 1 - R641L nicked DNA complex
Descriptor: ADENOSINE MONOPHOSPHATE, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*TP*C)-3'), DNA (5'-D(*GP*TP*CP*CP*GP*AP*CP*GP*AP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3'), ...
Authors:Tumbale, P.P, Williams, R.S, Schellenberg, M.S.
Deposit date:2020-12-17
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (1.901 Å)
Cite:LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.
Nucleic Acids Res., 49, 2021
7L35
DownloadVisualize
BU of 7l35 by Molmil
Human DNA Ligase 1 - R771W nicked DNA complex
Descriptor: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ADENOSINE MONOPHOSPHATE, DI(HYDROXYETHYL)ETHER, ...
Authors:Tumbale, P.P, Williams, R.S, Schellenberg, M.S.
Deposit date:2020-12-17
Release date:2021-01-13
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:LIG1 syndrome mutations remodel a cooperative network of ligand binding interactions to compromise ligation efficiency.
Nucleic Acids Res., 49, 2021
1CR9
DownloadVisualize
BU of 1cr9 by Molmil
CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4
Descriptor: FAB ANTIBODY HEAVY CHAIN, FAB ANTIBODY LIGHT CHAIN
Authors:Kanyo, Z.F, Pan, K.M, Williamson, R.A, Burton, D.R, Prusiner, S.B, Fletterick, R.J, Cohen, F.E.
Deposit date:1999-08-14
Release date:2000-04-17
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.
J.Mol.Biol., 293, 1999
1CU4
DownloadVisualize
BU of 1cu4 by Molmil
CRYSTAL STRUCTURE OF THE ANTI-PRION FAB 3F4 IN COMPLEX WITH ITS PEPTIDE EPITOPE
Descriptor: FAB HEAVY CHAIN, FAB LIGHT CHAIN, RECOGNITION PEPTIDE
Authors:Kanyo, Z.F, Pan, K.M, Williamson, R.A, Burton, D.R, Prusiner, S.B, Fletterick, R.J, Cohen, F.E.
Deposit date:1999-08-20
Release date:2000-04-17
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Antibody binding defines a structure for an epitope that participates in the PrPC-->PrPSc conformational change.
J.Mol.Biol., 293, 1999
6CQG
DownloadVisualize
BU of 6cqg by Molmil
YycF Effector Domain Structure without DNA bound
Descriptor: DNA-binding response regulator, ZINC ION
Authors:Riboldi-Tunnicliffe, A, Gabrielsen, M, Williamson, R.M, Panjikar, S.
Deposit date:2018-03-15
Release date:2019-06-19
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.932 Å)
Cite:YycF Effector Domain Structure without DNA bound
To Be Published
1WA8
DownloadVisualize
BU of 1wa8 by Molmil
Solution Structure of the CFP-10.ESAT-6 Complex. Major Virulence Determinants of Pathogenic Mycobacteria
Descriptor: 6 KDA EARLY SECRETORY ANTIGENIC TARGET (ESAT-6), ESAT-6 LIKE PROTEIN ESXB
Authors:Renshaw, P.S, Lightbody, K.L, Veverka, V, Muskett, F.W, Kelly, G, Frenkiel, T.A, Gordon, S.V, Hewinson, R.G, Burke, B, Norman, J, Williamson, R.A, Carr, M.D, TB Structural Genomics Consortium (TBSGC)
Deposit date:2004-10-25
Release date:2005-06-27
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure and Function of the Complex Formed by the Tuberculosis Virulence Factors Cfp-10 and Esat-6
Embo J., 24, 2005

227344

PDB entries from 2024-11-13

PDB statisticsPDBj update infoContact PDBjnumon