5KIV
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![BU of 5kiv by Molmil](/molmil-images/mine/5kiv) | Crystal structure of SauMacro (SAV0325) | Descriptor: | 1,2-ETHANEDIOL, ETHANOL, Protein-ADP-ribose hydrolase, ... | Authors: | Williams, R.S, Appel, C.D, Feld, G.K, Wallace, B.D. | Deposit date: | 2016-06-17 | Release date: | 2016-07-13 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus. Protein Sci., 25, 2016
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1LMK
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![BU of 1lmk by Molmil](/molmil-images/mine/1lmk) | THE STRUCTURE OF A BIVALENT DIABODY | Descriptor: | ANTI-PHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE C DIABODY | Authors: | Williams, R.L. | Deposit date: | 1994-08-29 | Release date: | 1995-03-31 | Last modified: | 2024-06-05 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structure of a diabody, a bivalent antibody fragment. Structure, 2, 1994
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1RBB
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![BU of 1rbb by Molmil](/molmil-images/mine/1rbb) | |
1NSK
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![BU of 1nsk by Molmil](/molmil-images/mine/1nsk) | |
6GPN
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![BU of 6gpn by Molmil](/molmil-images/mine/6gpn) | |
6GPE
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![BU of 6gpe by Molmil](/molmil-images/mine/6gpe) | |
7UOA
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![BU of 7uoa by Molmil](/molmil-images/mine/7uoa) | MAGEA4-MTP1 linear peptide complex | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTP-1, ... | Authors: | Williams, R.S, Tumbale, P.S. | Deposit date: | 2022-04-12 | Release date: | 2022-09-07 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4. J.Med.Chem., 65, 2022
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1NQB
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![BU of 1nqb by Molmil](/molmil-images/mine/1nqb) | TRIVALENT ANTIBODY FRAGMENT | Descriptor: | SINGLE-CHAIN ANTIBODY FRAGMENT | Authors: | Williams, R.L, Pei, X.Y. | Deposit date: | 1997-04-04 | Release date: | 1997-08-20 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3. Proc.Natl.Acad.Sci.USA, 94, 1997
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5OQ4
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![BU of 5oq4 by Molmil](/molmil-images/mine/5oq4) | PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology | Descriptor: | 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | Authors: | Williams, R.L, Zhang, X. | Deposit date: | 2017-08-10 | Release date: | 2017-09-06 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | 5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology. J. Med. Chem., 60, 2017
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1E7U
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![BU of 1e7u by Molmil](/molmil-images/mine/1e7u) | Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine | Descriptor: | (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT | Authors: | Walker, E.H, Perisic, O, Ried, C, Stephens, L, Williams, R.L. | Deposit date: | 2000-09-08 | Release date: | 2000-11-17 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine Mol.Cell, 6, 2000
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1E50
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![BU of 1e50 by Molmil](/molmil-images/mine/1e50) | AML1/CBFbeta complex | Descriptor: | CORE-BINDING FACTOR ALPHA SUBUNIT, CORE-BINDING FACTOR CBF-BETA | Authors: | Warren, A.J, Bravo, J, Williams, R.L, Rabbits, T.H. | Deposit date: | 2000-07-13 | Release date: | 2001-07-12 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural Basis for the Heterodimeric Interaction between the Acute Leukaemia-Associated Transcription Factors Aml1 and Cbfbeta Embo J., 19, 2000
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1W7P
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![BU of 1w7p by Molmil](/molmil-images/mine/1w7p) | The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36) | Descriptor: | VPS22, YPL002C, VPS25, ... | Authors: | Teo, H, Perisic, O, Gonzalez, B, Williams, R.L. | Deposit date: | 2004-09-07 | Release date: | 2004-09-29 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Escrt-II, an Endosome-Associated Complex Required for Protein Sorting: Crystal Structure and Interactions with Escrt-III and Membranes Dev.Cell, 7, 2004
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1W2C
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![BU of 1w2c by Molmil](/molmil-images/mine/1w2c) | Human Inositol (1,4,5) trisphosphate 3-kinase complexed with Mn2+/AMPPNP/Ins(1,4,5)P3 | Descriptor: | D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, INOSITOL-TRISPHOSPHATE 3-KINASE A, MANGANESE (II) ION, ... | Authors: | Gonzalez, B, Schell, M.J, Irvine, R.F, Williams, R.L. | Deposit date: | 2004-07-01 | Release date: | 2004-09-09 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase Mol.Cell, 15, 2004
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6S6D
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![BU of 6s6d by Molmil](/molmil-images/mine/6s6d) | Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L. | Deposit date: | 2019-07-02 | Release date: | 2019-10-16 | Last modified: | 2024-05-15 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Architecture of human Rag GTPase heterodimers and their complex with mTORC1. Science, 366, 2019
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2G50
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![BU of 2g50 by Molmil](/molmil-images/mine/2g50) | The location of the allosteric amino acid binding site of muscle pyruvate kinase. | Descriptor: | 1,2-ETHANEDIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ALANINE, ... | Authors: | Holyoak, T, Williams, R, Fenton, A.W. | Deposit date: | 2006-02-22 | Release date: | 2006-05-09 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase. Biochemistry, 45, 2006
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4PUQ
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![BU of 4puq by Molmil](/molmil-images/mine/4puq) | Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+ | Descriptor: | ACETATE ION, DNA/RNA hybrid, GLYCEROL, ... | Authors: | Schellenberg, M.J, Williams, R.S. | Deposit date: | 2014-03-13 | Release date: | 2014-05-14 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2). J.Biol.Chem., 289, 2014
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5W7P
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![BU of 5w7p by Molmil](/molmil-images/mine/5w7p) | Crystal structure of OxaC | Descriptor: | OxaC, S-ADENOSYLMETHIONINE | Authors: | Newmister, S.A, Romminger, S, Schmidt, J.J, Williams, R.M, Smith, J.L, Berlinck, R.G.S, Sherman, D.H. | Deposit date: | 2017-06-20 | Release date: | 2018-06-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. Org. Biomol. Chem., 16, 2018
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5W7K
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![BU of 5w7k by Molmil](/molmil-images/mine/5w7k) | Crystal structure of OxaG | Descriptor: | CHLORIDE ION, OxaG, S-ADENOSYL-L-HOMOCYSTEINE | Authors: | Newmister, S.A, Romminger, S, Schmidt, J.J, Williams, R.M, Smith, J.L, Berlinck, R.G.S, Sherman, D.H. | Deposit date: | 2017-06-20 | Release date: | 2018-06-27 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.994 Å) | Cite: | Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. Org. Biomol. Chem., 16, 2018
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5W7S
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![BU of 5w7s by Molmil](/molmil-images/mine/5w7s) | Crystal structure of OxaC in complex with sinefungin and meleagrin | Descriptor: | (3E,7aR,12aS)-6-hydroxy-3-[(1H-imidazol-4-yl)methylidene]-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione, OxaC, SINEFUNGIN | Authors: | Newmister, S.A, Romminger, S, Schmidt, J.J, Williams, R.M, Smith, J.L, Berlinck, R.G.S, Sherman, D.H. | Deposit date: | 2017-06-20 | Release date: | 2018-06-27 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.948 Å) | Cite: | Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway. Org. Biomol. Chem., 16, 2018
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5INP
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4GZ1
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![BU of 4gz1 by Molmil](/molmil-images/mine/4gz1) | |
5INO
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5INN
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![BU of 5inn by Molmil](/molmil-images/mine/5inn) | Mouse Tdp2 D358N protein, apo state with increased disorder amongst variable DNA-binding grasp conformations | Descriptor: | CHLORIDE ION, GLYCEROL, SULFATE ION, ... | Authors: | Schellenberg, M.J, Appel, C.D, Williams, R.S. | Deposit date: | 2016-03-07 | Release date: | 2016-04-27 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2. Nucleic Acids Res., 44, 2016
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2G3P
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4RE2
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![BU of 4re2 by Molmil](/molmil-images/mine/4re2) | Different transition state conformations for the hydrolysis of beta-mannosides and beta-glucosides in the rice Os7BGlu26 family GH1 beta-mannosidase/beta-glucosidase | Descriptor: | (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Tankrathok, A, Iglesias-Fernandez, J, Williams, R.J, Hakki, Z, Robinson, R.C, Hrmova, M, Rovira, C, Williams, S.J, Ketudat Cairns, J.R. | Deposit date: | 2014-09-21 | Release date: | 2015-09-16 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides ACS CATALYSIS, 5, 2015
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