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PDB: 252 件
5KIV
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BU of 5kiv by Molmil
Crystal structure of SauMacro (SAV0325)
分子名称: 1,2-ETHANEDIOL, ETHANOL, Protein-ADP-ribose hydrolase, ...
著者Williams, R.S, Appel, C.D, Feld, G.K, Wallace, B.D.
登録日2016-06-17
公開日2016-07-13
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus.
Protein Sci., 25, 2016
1LMK
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BU of 1lmk by Molmil
THE STRUCTURE OF A BIVALENT DIABODY
分子名称: ANTI-PHOSPHATIDYLINOSITOL SPECIFIC PHOSPHOLIPASE C DIABODY
著者Williams, R.L.
登録日1994-08-29
公開日1995-03-31
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Crystal structure of a diabody, a bivalent antibody fragment.
Structure, 2, 1994
1RBB
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BU of 1rbb by Molmil
THE CRYSTAL STRUCTURE OF RIBONUCLEASE B AT 2.5-ANGSTROMS RESOLUTION
分子名称: RIBONUCLEASE B
著者Williams, R.L, Greene, S.M, McPherson, A.
登録日1987-09-14
公開日1988-07-16
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of ribonuclease B at 2.5-A resolution.
J.Biol.Chem., 262, 1987
1NSK
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BU of 1nsk by Molmil
THE CRYSTAL STRUCTURE OF A HUMAN NUCLEOSIDE DIPHOSPHATE KINASE, NM23-H2
分子名称: NUCLEOSIDE DIPHOSPHATE KINASE
著者Williams, R.L, Perisic, O.
登録日1995-07-04
公開日1995-10-15
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The crystal structure of a human nucleoside diphosphate kinase, NM23-H2.
J.Mol.Biol., 251, 1995
6GPN
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BU of 6gpn by Molmil
Crystal Structure of the CsiD Glutarate Hydroxylase in complex with N-Oxalylglycine
分子名称: FE (II) ION, Glutarate 2-hydroxylase, N-OXALYLGLYCINE
著者Williams, R.M, Mayans, O, Hartig, J.S.
登録日2018-06-06
公開日2019-01-30
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
Nat Commun, 9, 2018
6GPE
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BU of 6gpe by Molmil
Crystal Structure of the CsiD Glutarate Hydroxylase
分子名称: FE (II) ION, Protein CsiD
著者Williams, R.M, Mayans, O, Hartig, J.S.
登録日2018-06-05
公開日2018-12-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Widespread bacterial lysine degradation proceeding via glutarate and L-2-hydroxyglutarate.
Nat Commun, 9, 2018
7UOA
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BU of 7uoa by Molmil
MAGEA4-MTP1 linear peptide complex
分子名称: 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, MTP-1, ...
著者Williams, R.S, Tumbale, P.S.
登録日2022-04-12
公開日2022-09-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4.
J.Med.Chem., 65, 2022
1NQB
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BU of 1nqb by Molmil
TRIVALENT ANTIBODY FRAGMENT
分子名称: SINGLE-CHAIN ANTIBODY FRAGMENT
著者Williams, R.L, Pei, X.Y.
登録日1997-04-04
公開日1997-08-20
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The 2.0-A resolution crystal structure of a trimeric antibody fragment with noncognate VH-VL domain pairs shows a rearrangement of VH CDR3.
Proc.Natl.Acad.Sci.USA, 94, 1997
5OQ4
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BU of 5oq4 by Molmil
PQR309 - a Potent, Brain-Penetrant, Orally Bioavailable, pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology
分子名称: 5-(4,6-dimorpholin-4-yl-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION
著者Williams, R.L, Zhang, X.
登録日2017-08-10
公開日2017-09-06
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献5-(4,6-Dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine (PQR309), a Potent, Brain-Penetrant, Orally Bioavailable, Pan-Class I PI3K/mTOR Inhibitor as Clinical Candidate in Oncology.
J. Med. Chem., 60, 2017
1E7U
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BU of 1e7u by Molmil
Structure determinants of phosphoinositide 3-kinase inhibition by wortmannin, LY294002, quercetin, myricetin and staurosporine
分子名称: (1S,6BR,9AS,11R,11BR)-9A,11B-DIMETHYL-1-[(METHYLOXY)METHYL]-3,6,9-TRIOXO-1,6,6B,7,8,9,9A,10,11,11B-DECAHYDRO-3H-FURO[4, 3,2-DE]INDENO[4,5-H][2]BENZOPYRAN-11-YL ACETATE, PHOSPHATIDYLINOSITOL 3-KINASE CATALYTIC SUBUNIT
著者Walker, E.H, Perisic, O, Ried, C, Stephens, L, Williams, R.L.
登録日2000-09-08
公開日2000-11-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural Determinations of Phosphoinositide 3-Kinase Inhibition by Wortmannin, Ly294002, Quercetin, Myricetin and Staurosporine
Mol.Cell, 6, 2000
1E50
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BU of 1e50 by Molmil
AML1/CBFbeta complex
分子名称: CORE-BINDING FACTOR ALPHA SUBUNIT, CORE-BINDING FACTOR CBF-BETA
著者Warren, A.J, Bravo, J, Williams, R.L, Rabbits, T.H.
登録日2000-07-13
公開日2001-07-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structural Basis for the Heterodimeric Interaction between the Acute Leukaemia-Associated Transcription Factors Aml1 and Cbfbeta
Embo J., 19, 2000
1W7P
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BU of 1w7p by Molmil
The crystal structure of endosomal complex ESCRT-II (VPS22/VPS25/VPS36)
分子名称: VPS22, YPL002C, VPS25, ...
著者Teo, H, Perisic, O, Gonzalez, B, Williams, R.L.
登録日2004-09-07
公開日2004-09-29
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Escrt-II, an Endosome-Associated Complex Required for Protein Sorting: Crystal Structure and Interactions with Escrt-III and Membranes
Dev.Cell, 7, 2004
1W2C
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BU of 1w2c by Molmil
Human Inositol (1,4,5) trisphosphate 3-kinase complexed with Mn2+/AMPPNP/Ins(1,4,5)P3
分子名称: D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, INOSITOL-TRISPHOSPHATE 3-KINASE A, MANGANESE (II) ION, ...
著者Gonzalez, B, Schell, M.J, Irvine, R.F, Williams, R.L.
登録日2004-07-01
公開日2004-09-09
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structure of a Human Inositol 1,4,5-Trisphosphate 3-Kinase; Substrate Binding Reveals Why It is not a Phosphoinositide 3-Kinase
Mol.Cell, 15, 2004
6S6D
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BU of 6s6d by Molmil
Crystal structure of RagA-Q66L-GTP/RagC-S75N-GDP GTPase heterodimer complex
分子名称: GUANOSINE-5'-DIPHOSPHATE, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Anandapadamanaban, M, Masson, G.R, Perisic, O, Kaufman, J, Williams, R.L.
登録日2019-07-02
公開日2019-10-16
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Architecture of human Rag GTPase heterodimers and their complex with mTORC1.
Science, 366, 2019
2G50
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BU of 2g50 by Molmil
The location of the allosteric amino acid binding site of muscle pyruvate kinase.
分子名称: 1,2-ETHANEDIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, ALANINE, ...
著者Holyoak, T, Williams, R, Fenton, A.W.
登録日2006-02-22
公開日2006-05-09
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Differentiating a Ligand's Chemical Requirements for Allosteric Interactions from Those for Protein Binding. Phenylalanine Inhibition of Pyruvate Kinase.
Biochemistry, 45, 2006
4PUQ
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BU of 4puq by Molmil
Mus Musculus Tdp2 reaction product complex with 5'-phosphorylated RNA/DNA, glycerol, and Mg2+
分子名称: ACETATE ION, DNA/RNA hybrid, GLYCEROL, ...
著者Schellenberg, M.J, Williams, R.S.
登録日2014-03-13
公開日2014-05-14
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Proteolytic Degradation of Topoisomerase II (Top2) Enables the Processing of Top2DNA and Top2RNA Covalent Complexes by Tyrosyl-DNA-Phosphodiesterase 2 (TDP2).
J.Biol.Chem., 289, 2014
5W7P
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BU of 5w7p by Molmil
Crystal structure of OxaC
分子名称: OxaC, S-ADENOSYLMETHIONINE
著者Newmister, S.A, Romminger, S, Schmidt, J.J, Williams, R.M, Smith, J.L, Berlinck, R.G.S, Sherman, D.H.
登録日2017-06-20
公開日2018-06-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.
Org. Biomol. Chem., 16, 2018
5W7K
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BU of 5w7k by Molmil
Crystal structure of OxaG
分子名称: CHLORIDE ION, OxaG, S-ADENOSYL-L-HOMOCYSTEINE
著者Newmister, S.A, Romminger, S, Schmidt, J.J, Williams, R.M, Smith, J.L, Berlinck, R.G.S, Sherman, D.H.
登録日2017-06-20
公開日2018-06-27
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.994 Å)
主引用文献Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.
Org. Biomol. Chem., 16, 2018
5W7S
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BU of 5w7s by Molmil
Crystal structure of OxaC in complex with sinefungin and meleagrin
分子名称: (3E,7aR,12aS)-6-hydroxy-3-[(1H-imidazol-4-yl)methylidene]-12-methoxy-7a-(2-methylbut-3-en-2-yl)-7a,12-dihydro-1H,5H-imidazo[1',2':1,2]pyrido[2,3-b]indole-2,5(3H)-dione, OxaC, SINEFUNGIN
著者Newmister, S.A, Romminger, S, Schmidt, J.J, Williams, R.M, Smith, J.L, Berlinck, R.G.S, Sherman, D.H.
登録日2017-06-20
公開日2018-06-27
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.948 Å)
主引用文献Unveiling sequential late-stage methyltransferase reactions in the meleagrin/oxaline biosynthetic pathway.
Org. Biomol. Chem., 16, 2018
5INP
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BU of 5inp by Molmil
Mouse Tdp2 reaction product (5'-phosphorylated DNA)-Mn2+ complex
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), MANGANESE (II) ION, ...
著者Schellenberg, M.J, Williams, R.S.
登録日2016-03-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.947 Å)
主引用文献Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
4GZ1
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Mus Musculus Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex at 1.5 Angstroms resolution
分子名称: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), FORMIC ACID, ...
著者Schellenberg, M.J, Williams, R.S.
登録日2012-09-05
公開日2012-10-31
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Mechanism of repair of 5'-topoisomerase II-DNA adducts by mammalian tyrosyl-DNA phosphodiesterase 2.
Nat.Struct.Mol.Biol., 19, 2012
5INO
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BU of 5ino by Molmil
Human Tdp2 reaction product (5'-phosphorylated DNA)-Mg2+ complex
分子名称: DNA (5'-D(P*CP*CP*GP*AP*AP*TP*TP*CP*G)-3'), SULFATE ION, Tyrosyl-DNA phosphodiesterase 2
著者Schellenberg, M.J, Williams, R.S.
登録日2016-03-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (3.205 Å)
主引用文献Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
5INN
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Mouse Tdp2 D358N protein, apo state with increased disorder amongst variable DNA-binding grasp conformations
分子名称: CHLORIDE ION, GLYCEROL, SULFATE ION, ...
著者Schellenberg, M.J, Appel, C.D, Williams, R.S.
登録日2016-03-07
公開日2016-04-27
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
Nucleic Acids Res., 44, 2016
2G3P
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STRUCTURE OF THE N-TERMINAL TWO DOMAINS OF THE INFECTIVITY PROTEIN G3P OF FILAMENTOUS PHAGE FD
分子名称: INFECTIVITY PROTEIN G3P
著者Holliger, P, Williams, R.L.
登録日1998-10-27
公開日1999-07-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Crystal structure of the two N-terminal domains of g3p from filamentous phage fd at 1.9 A: evidence for conformational lability.
J.Mol.Biol., 288, 1999
4RE2
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BU of 4re2 by Molmil
Different transition state conformations for the hydrolysis of beta-mannosides and beta-glucosides in the rice Os7BGlu26 family GH1 beta-mannosidase/beta-glucosidase
分子名称: (5R,6R,7S,8R)-5-(HYDROXYMETHYL)-5,6,7,8-TETRAHYDROIMIDAZO[1,2-A]PYRIDINE-6,7,8-TRIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ...
著者Tankrathok, A, Iglesias-Fernandez, J, Williams, R.J, Hakki, Z, Robinson, R.C, Hrmova, M, Rovira, C, Williams, S.J, Ketudat Cairns, J.R.
登録日2014-09-21
公開日2015-09-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献A Single Glycosidase Harnesses Different Pyranoside Ring Transition State Conformations for Hydrolysis of Mannosides and Glucosides
ACS CATALYSIS, 5, 2015

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