8SKK
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![BU of 8skk by Molmil](/molmil-images/mine/8skk) | Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL17 | Descriptor: | C-C motif chemokine 17, Evasin P1243 | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2023-04-19 | Release date: | 2023-05-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of the Tick Evasin EVA-AAM1001(L39P) Complexed to Human Chemokine CCL7 To be Published
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6APW
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![BU of 6apw by Molmil](/molmil-images/mine/6apw) | Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor | Descriptor: | 4-[(4-{5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentyl}-1H-1,2,3-triazol-1-yl)methyl]benzoic acid, Bifunctional ligase/repressor BirA | Authors: | Cini, D.A, Wilce, M.C.J. | Deposit date: | 2017-08-18 | Release date: | 2018-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.614 Å) | Cite: | Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus. ACS Infect Dis, 4, 2018
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6AQQ
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![BU of 6aqq by Molmil](/molmil-images/mine/6aqq) | Crystal structure of Staphylococcus aureus biotin protein ligase in complex with inhibitor | Descriptor: | (3aS,4S,6aR)-4-(5-{1-[(3-fluorophenyl)methyl]-1H-1,2,3-triazol-4-yl}pentyl)tetrahydro-1H-thieno[3,4-d]imidazol-2(3H)-one, Bifunctional ligase/repressor BirA | Authors: | Cini, D.A, Wilce, M.C.J. | Deposit date: | 2017-08-21 | Release date: | 2018-02-07 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Halogenation of Biotin Protein Ligase Inhibitors Improves Whole Cell Activity against Staphylococcus aureus. ACS Infect Dis, 4, 2018
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2DPD
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![BU of 2dpd by Molmil](/molmil-images/mine/2dpd) | |
2DQR
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![BU of 2dqr by Molmil](/molmil-images/mine/2dqr) | |
4TZG
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![BU of 4tzg by Molmil](/molmil-images/mine/4tzg) | Crystal structure of eCGP123, an extremely thermostable green fluorescent protein | Descriptor: | Fluorescent Protein | Authors: | Close, D.W, Don Paul, C, Traore, D.A.K, Wilce, M.C.J, Prescott, M, Bradbury, A.R.M. | Deposit date: | 2014-07-10 | Release date: | 2014-10-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Thermal green protein, an extremely stable, nonaggregating fluorescent protein created by structure-guided surface engineering. Proteins, 83, 2015
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2WZM
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![BU of 2wzm by Molmil](/molmil-images/mine/2wzm) | Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form | Descriptor: | ALDO-KETO REDUCTASE, [(2R,3R,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3-HYDROXY-4-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL [(2R,3S,4S)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL]METHYL DIHYDROGEN DIPHOSPHATE | Authors: | Scoble, J, McAlister, A.D, Fulton, Z, Troy, S, Byres, E, Vivian, J.P, Brammananth, R, Wilce, M.C.J, Le Nours, J, Zaker-Tabrizi, L, Coppel, R.L, Crellin, P.K, Rossjohn, J, Beddoe, T. | Deposit date: | 2009-11-30 | Release date: | 2010-02-16 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase. J.Mol.Biol., 398, 2010
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2WZT
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![BU of 2wzt by Molmil](/molmil-images/mine/2wzt) | Crystal structure of a mycobacterium aldo-keto reductase in its apo and liganded form | Descriptor: | ALDO-KETO REDUCTASE | Authors: | Scoble, J, McAlister, A.D, Fulton, Z, Troy, S, Byres, E, Vivian, J.P, Brammananth, R, Wilce, M.C.J, Le Nours, J, Zaker-Tabrizi, L, Coppel, R.L, Crellin, P.K, Rossjohn, J, Beddoe, T. | Deposit date: | 2009-12-03 | Release date: | 2010-02-16 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal Structure and Comparative Functional Analyses of a Mycobacterium Aldo-Keto Reductase. J.Mol.Biol., 398, 2010
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2NO4
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![BU of 2no4 by Molmil](/molmil-images/mine/2no4) | Crystal Structure analysis of a Dehalogenase | Descriptor: | (S)-2-haloacid dehalogenase IVA, CHLORIDE ION, SULFATE ION | Authors: | Schmidberger, J.W, Wilce, M.C.J. | Deposit date: | 2006-10-24 | Release date: | 2007-09-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.93 Å) | Cite: | Crystal structures of the substrate free-enzyme, and reaction intermediate of the HAD superfamily member, haloacid dehalogenase DehIVa from Burkholderia cepacia MBA4 J.Mol.Biol., 368, 2007
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2NO5
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![BU of 2no5 by Molmil](/molmil-images/mine/2no5) | Crystal Structure analysis of a Dehalogenase with intermediate complex | Descriptor: | (2S)-2-CHLOROPROPANOIC ACID, (S)-2-haloacid dehalogenase IVA, CHLORIDE ION, ... | Authors: | Schmidberger, J.W, Wilce, M.C.J. | Deposit date: | 2006-10-24 | Release date: | 2007-09-25 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal structures of the substrate free-enzyme, and reaction intermediate of the HAD superfamily member, haloacid dehalogenase DehIVa from Burkholderia cepacia MBA4 J.Mol.Biol., 368, 2007
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7SCT
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![BU of 7sct by Molmil](/molmil-images/mine/7sct) | Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL16 | Descriptor: | C-C motif chemokine 16, Evasin P1243 | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-29 | Release date: | 2023-03-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.84 Å) | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat Commun, 14, 2023
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7SCV
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![BU of 7scv by Molmil](/molmil-images/mine/7scv) | Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL17 | Descriptor: | C-C motif chemokine 17, Evasin P1243 | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-29 | Release date: | 2023-03-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat Commun, 14, 2023
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7SCS
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![BU of 7scs by Molmil](/molmil-images/mine/7scs) | Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL11 | Descriptor: | Eotaxin, Evasin P1243 | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-29 | Release date: | 2023-03-29 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.51 Å) | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat Commun, 14, 2023
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4WOP
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![BU of 4wop by Molmil](/molmil-images/mine/4wop) | Nucleotide Triphosphate Promiscuity in Mycobacterium tuberculosis Dethiobiotin Synthetase | Descriptor: | ATP-dependent dethiobiotin synthetase BioD, CYTIDINE-5'-TRIPHOSPHATE, SULFATE ION | Authors: | Salaemae, W, Yap, M.Y, Wegener, K.L, Booker, G.W, Wilce, M.C.J, Polyak, S.W. | Deposit date: | 2014-10-16 | Release date: | 2015-04-08 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.393 Å) | Cite: | Nucleotide triphosphate promiscuity in Mycobacterium tuberculosis dethiobiotin synthetase. Tuberculosis (Edinb), 95, 2015
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1J0R
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![BU of 1j0r by Molmil](/molmil-images/mine/1j0r) | Crystal structure of the replication termination protein mutant C110S | Descriptor: | replication termination protein | Authors: | Vivian, J.P, Hastings, A.F, Duggin, I.G, Wake, R.G, Wilce, M.C.J, Wilce, J.A. | Deposit date: | 2002-11-20 | Release date: | 2003-11-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The impact of single cysteine residue mutations on the replication terminator protein Biochem.Biophys.Res.Commun., 310, 2003
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8FK6
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![BU of 8fk6 by Molmil](/molmil-images/mine/8fk6) | Crystal Structure of the Tick Evasin EVA-AAM1001(Y44A) Complexed to Human Chemokine CCL7 | Descriptor: | C-C motif chemokine 7, Evasin P1243 | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2022-12-20 | Release date: | 2023-03-29 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins. Nat Commun, 14, 2023
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2IY9
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![BU of 2iy9 by Molmil](/molmil-images/mine/2iy9) | Crystal structure of the A-subunit of the AB5 toxin from E. coli | Descriptor: | SUBA | Authors: | Paton, A.W, Beddoe, T, Thorpe, C.M, Whisstock, J.C, Wilce, M.C.J, Rossjohn, J, Talbot, U.M, Paton, J.C. | Deposit date: | 2006-07-13 | Release date: | 2006-10-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Ab5 Subtilase Cytotoxin Inactivates the Endoplasmic Reticulum Chaperone Bip Nature, 443, 2006
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2MHC
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![BU of 2mhc by Molmil](/molmil-images/mine/2mhc) | NMR structure of the catalytic domain of the large serine resolvase TnpX | Descriptor: | TnpX | Authors: | Headey, S.J, Sivakumaran, A, Adams, V, Rodgers, A.J.W, Rood, J.I, Scanlon, M.J, Wilce, M.C.J. | Deposit date: | 2013-11-20 | Release date: | 2014-11-26 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution Structure and DNA Binding of the Catalytic of the Large Serine Resolvase Tnpx To be Published
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7SCU
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![BU of 7scu by Molmil](/molmil-images/mine/7scu) | Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL7 | Descriptor: | C-C motif chemokine 7, Evasin P1243 | Authors: | Devkota, S.R, Bhusal, R.P, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-29 | Release date: | 2023-04-05 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal Structure of Tick Evasin EVA-AAM1001 complexed to human chemokine CCL7 To Be Published
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7SO0
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![BU of 7so0 by Molmil](/molmil-images/mine/7so0) | Crystal Structure of the Engineered Tick Evasin EVA-P974(F31A) Complexed to Human Chemokine CCL2 | Descriptor: | C-C motif chemokine 2, Evasin P974 | Authors: | Bhusal, R.P, Devkota, S.R, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-10-28 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc.Natl.Acad.Sci.USA, 119, 2022
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7S5A
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![BU of 7s5a by Molmil](/molmil-images/mine/7s5a) | Crystal structure of human chemokine CCL8 | Descriptor: | C-C motif chemokine 8 | Authors: | Bhusal, R.P, Devkota, S.R, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-10 | Release date: | 2021-09-29 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.37 Å) | Cite: | Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc.Natl.Acad.Sci.USA, 119, 2022
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7S59
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![BU of 7s59 by Molmil](/molmil-images/mine/7s59) | Crystal structure of the tick evasin EVA-P974 complexed to a chimera made of human chemokines CCL7 and CCL8 | Descriptor: | Evasin P974, SULFATE ION, chimera protein of C-C motif chemokine 7 and C-C motif chemokine 8,C-C motif chemokine 7 | Authors: | Bhusal, R.P, Devkota, S.R, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-10 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc.Natl.Acad.Sci.USA, 119, 2022
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7S4N
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![BU of 7s4n by Molmil](/molmil-images/mine/7s4n) | Crystal structure of the tick evasin EVA-P974 complexed to human chemokine CCL17 | Descriptor: | C-C motif chemokine 17, Evasin P974 | Authors: | Bhusal, R.P, Devkota, S.R, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-09 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc.Natl.Acad.Sci.USA, 119, 2022
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7S58
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![BU of 7s58 by Molmil](/molmil-images/mine/7s58) | Crystal Structure of the tick evasin EVA-P974 complexed to human chemokine CCL7 | Descriptor: | C-C motif chemokine 7, Evasin P974 | Authors: | Bhusal, R.P, Devkota, S.R, Aryal, P, Wilce, M.C.J, Stone, M.J. | Deposit date: | 2021-09-10 | Release date: | 2022-03-16 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Structure-guided engineering of tick evasins for targeting chemokines in inflammatory diseases. Proc.Natl.Acad.Sci.USA, 119, 2022
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4PPK
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![BU of 4ppk by Molmil](/molmil-images/mine/4ppk) | Crystal structure of eCGP123 T69V variant at pH 7.5 | Descriptor: | Monomeric Azami Green | Authors: | Don Paul, C, Traore, D.A.K, Devenish, R.J, Close, D, Bell, T, Bradbury, A, Wilce, M.C.J, Prescott, M. | Deposit date: | 2014-02-27 | Release date: | 2015-04-08 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | X-Ray Crystal Structure and Properties of Phanta, a Weakly Fluorescent Photochromic GFP-Like Protein. Plos One, 10, 2015
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