7SCS

Crystal Structure of the Tick Evasin EVA-AAM1001 Complexed to Human Chemokine CCL11

Summary for 7SCS

• Entry DOI: 10.2210/pdb7scs/pdb
• Descriptor: Evasin P1243, Eotaxin (3 entities in total)
• Functional Keywords: chemokine, evasin, ticks, inflammation, immune system
• Biological source: Amblyomma americanum (Lone star tick); More
• Total number of polymer chains: 2
• Total formula weight: 19495.40

Authors

Devkota, S.R.,Bhusal, R.P.,Aryal, P.,Wilce, M.C.J.,Stone, M.J. (deposition date: 2021-09-29, release date: 2023-03-29, Last modification date: 2023-10-25)

• Primary citation: Devkota, S.R.,Aryal, P.,Pokhrel, R.,Jiao, W.,Perry, A.,Panjikar, S.,Payne, R.J.,Wilce, M.C.J.,Bhusal, R.P.,Stone, M.J.; Engineering broad-spectrum inhibitors of inflammatory chemokines from subclass A3 tick evasins.; Nat Commun, 14:4204-4204, 2023; PubMed: 37452046; DOI: 10.1038/s41467-023-39879-3

Experimental method

X-RAY DIFFRACTION (1.51 Å)