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PDB: 16 件
3KEH
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BU of 3keh by Molmil
Crystal Structure of N370S Glucocerebrosidase mutant at pH 7.4
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wei, R.R, Boucher, S, Pan, C.Q, Edmunds, T.
登録日2009-10-26
公開日2010-10-27
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal Structure of Glucocerebrosidase Containing the N370S mutation: Implication on Chaperon Therapy
To be Published
3KE0
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BU of 3ke0 by Molmil
Crystal structure of N370S Glucocerebrosidase at acidic pH.
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wei, R.R, Boucher, S, Pan, C.Q, Edmunds, T.
登録日2009-10-23
公開日2010-10-27
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Crystal Structure of Glucocerebrosidase Containing the N370S Mutation, Implications for Chaperon Therapy
To be Published
2FTX
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BU of 2ftx by Molmil
Crystal structure of the yeast kinetochore Spc24/Spc25 globular domain
分子名称: Hypothetical 24.6 kDa protein in ILV2-ADE17 intergenic region, Hypothetical 25.2 kDa protein in AFG3-SEB2 intergenic region, PHOSPHATE ION, ...
著者Wei, R.R, Harrison, S.C.
登録日2006-01-25
公開日2006-06-13
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Atomic Structure of the kinetochore Spc24p/Spc25p globular domain reveals a novel fold
To be Published
2IGP
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BU of 2igp by Molmil
Crystal Structure of Hec1 CH domain
分子名称: BETA-MERCAPTOETHANOL, Retinoblastoma-associated protein HEC
著者Wei, R.R, Harrison, S.C.
登録日2006-09-22
公開日2007-01-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The Ndc80/HEC1 complex is a contact point for kinetochore-microtubule attachment.
Nat.Struct.Mol.Biol., 14, 2007
5WHZ
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BU of 5whz by Molmil
PGDM1400-10E8v4 CODV Fab
分子名称: Anti-HIV CODV-Fab Heavy chain, Anti-HIV CODV-Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2017-07-18
公開日2017-10-11
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (3.549 Å)
主引用文献Trispecific broadly neutralizing HIV antibodies mediate potent SHIV protection in macaques.
Science, 358, 2017
6O8D
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BU of 6o8d by Molmil
Anti-CD28xCD3 CODV Fab bound to CD28
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Anti-CD28xCD3 CODV Fab Heavy chain, ...
著者Lord, D.M, Wei, R.R.
登録日2019-03-09
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.547 Å)
主引用文献Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
To Be Published
6O89
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BU of 6o89 by Molmil
Anti-CD28xCD3 CODV Fab
分子名称: Anti-CD28xCD3 CODV-Fab Heavy chain, Anti-CD28xCD3 CODV-Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2019-03-09
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Trispecific antibodies enhance the therapeutic efficacy of tumor-directed T cells through T cell receptor co-stimulation
Nat Cancer, 1, 2020
5I8R
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BU of 5i8r by Molmil
aSMase with zinc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Sphingomyelin phosphodiesterase, ...
著者Zhou, Y.F, Wei, R.R.
登録日2016-02-19
公開日2016-09-07
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (3.646 Å)
主引用文献Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
5I85
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BU of 5i85 by Molmil
aSMase with zinc and phosphocholine
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHOCHOLINE, ...
著者Zhou, Y.F, Wei, R.R.
登録日2016-02-18
公開日2016-09-07
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
5I81
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BU of 5i81 by Molmil
aSMase with zinc
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SULFATE ION, ...
著者Zhou, Y.F, Wei, R.R.
登録日2016-02-18
公開日2016-09-07
最終更新日2021-03-24
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Human acid sphingomyelinase structures provide insight to molecular basis of Niemann-Pick disease.
Nat Commun, 7, 2016
6AMM
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BU of 6amm by Molmil
CAT192 Fab Insertion Mutant H0/L1
分子名称: CAT192 Fab Heavy chain, CAT192 Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2017-08-10
公開日2018-01-31
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
6AMJ
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BU of 6amj by Molmil
CAT192 Fab Wild Type
分子名称: CAT192 Fab heavy chain, CAT192 Fab light chain, DI(HYDROXYETHYL)ETHER, ...
著者Lord, D.M, Wei, R.R.
登録日2017-08-09
公開日2018-01-31
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
6AO0
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BU of 6ao0 by Molmil
CAT192 Fab Insertion Mutant H2/L2
分子名称: CAT192 Fab Heavy chain, CAT192 Fab Light chain, SULFATE ION
著者Lord, D.M, Wei, R.R.
登録日2017-08-15
公開日2018-01-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
6ANP
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BU of 6anp by Molmil
CAT192 Fab Insertion Mutant H5/L0
分子名称: CAT192 Fab Heavy chain, CAT192 Fab Light chain
著者Lord, D.M, Wei, R.R.
登録日2017-08-14
公開日2018-01-31
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Structure-based engineering to restore high affinity binding of an isoform-selective anti-TGF beta 1 antibody.
MAbs, 10, 2018
3R02
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BU of 3r02 by Molmil
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
分子名称: 7-[(cis-4-aminocyclohexyl)amino]-5-bromo-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1
著者Xiang, Y, Hirth, B, Asmussen, G, Biemann, H.-P, Good, A, Fitzgerald, M, Gladysheva, T, Jancsics, K, Liu, J, Metz, M, Papoulis, A, Skerlj, R, Stepp, D.J, Wei, R.R.
登録日2011-03-07
公開日2011-05-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011
3R04
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BU of 3r04 by Molmil
The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors
分子名称: 5-{6-[(trans-4-aminocyclohexyl)amino]pyrazin-2-yl}-1-benzofuran-2-carboxylic acid, IMIDAZOLE, Proto-oncogene serine/threonine-protein kinase pim-1
著者Xiang, Y, Hirth, B, Asmussen, G, Biemann, H.-P, Good, A, Fitzgerald, M, Gladysheva, T, Jancsics, K, Liu, J, Metz, M, Papoulis, A, Skerlj, R, Stepp, D.J, Wei, R.R.
登録日2011-03-07
公開日2011-05-11
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献The discovery of novel benzofuran-2-carboxylic acids as potent Pim-1 inhibitors.
Bioorg.Med.Chem.Lett., 21, 2011

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件を2024-11-06に公開中

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