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PDB: 120 件
1W1F
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SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE
分子名称: TYROSINE-PROTEIN KINASE LYN
著者Bauer, F, Schweimer, K, Hoffmann, S, Roesch, P, Sticht, H.
登録日2004-06-17
公開日2005-07-06
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Characterization of Lyn-SH3 Domain in Complex with a Herpesviral Protein Reveals an Extended Recognition Motif that Enhances Binding Affinity.
Protein Sci., 14, 2005
1WA7
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SH3 DOMAIN OF HUMAN LYN TYROSINE KINASE IN COMPLEX WITH A HERPESVIRAL LIGAND
分子名称: HYPOTHETICAL 28.7 KDA PROTEIN IN DHFR 3'REGION (ORF1), TYROSINE-PROTEIN KINASE LYN
著者Bauer, F, Schweimer, K, Hoffmann, S, Roesch, P, Sticht, H.
登録日2004-10-25
公開日2005-07-07
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Investigation of the Binding of a Herpesviral Protein to the SH3 Domain of Tyrosine Kinase Lck.
Biochemistry, 41, 2002
6ZL2
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Structure of a parallel c-Myc modified with 3' duplex stem-loop overhang
分子名称: DNA (36-MER)
著者Vianney, Y.M, Weisz, K.
登録日2020-06-30
公開日2020-10-07
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Quadruplex-Duplex Junction: A High-Affinity Binding Site for Indoloquinoline Ligands.
Chemistry, 26, 2020
3PEU
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S. cerevisiae Dbp5 L327V C-terminal domain bound to Gle1 H337R and IP6
分子名称: ATP-dependent RNA helicase DBP5, GLYCEROL, INOSITOL HEXAKISPHOSPHATE, ...
著者Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
登録日2010-10-27
公開日2011-03-23
最終更新日2020-10-14
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEW
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S. cerevisiae Dbp5 L327V bound to RNA and ADP BeF3
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, BERYLLIUM TRIFLUORIDE ION, ...
著者Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
登録日2010-10-27
公開日2011-03-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.501 Å)
主引用文献A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEV
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S. cerevisiae Dbp5 L327V C-terminal domain bound to Gle1 and IP6
分子名称: ATP-dependent RNA helicase DBP5, GLYCEROL, INOSITOL HEXAKISPHOSPHATE, ...
著者Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
登録日2010-10-27
公開日2011-03-23
最終更新日2020-10-14
実験手法X-RAY DIFFRACTION (2.499 Å)
主引用文献A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3PEY
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S. cerevisiae Dbp5 bound to RNA and ADP BeF3
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, BERYLLIUM TRIFLUORIDE ION, ...
著者Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
登録日2010-10-27
公開日2011-03-23
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.401 Å)
主引用文献A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP(6) in mRNA export.
Nature, 472, 2011
3RRM
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S. cerevisiae dbp5 l327v bound to nup159, gle1 h337r, ip6 and adp
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, INOSITOL HEXAKISPHOSPHATE, ...
著者Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
登録日2011-04-29
公開日2011-05-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Nature, 472, 2011
3RRN
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S. cerevisiae dbp5 l327v bound to gle1 h337r and ip6
分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase DBP5, INOSITOL HEXAKISPHOSPHATE, ...
著者Montpetit, B, Thomsen, N.D, Helmke, K.J, Seeliger, M.A, Berger, J.M, Weis, K.
登録日2011-04-29
公開日2011-05-18
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (4.001 Å)
主引用文献A conserved mechanism of DEAD-box ATPase activation by nucleoporins and InsP6 in mRNA export.
Nature, 472, 2011
8S1W
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Structure of a quadruplex-duplex hybrid with a (-pd+l) loop progression
分子名称: DNA (33-MER)
著者Vianney, Y.M, Jana, J, Weisz, K.
登録日2024-02-16
公開日2024-03-27
最終更新日2024-06-05
実験手法SOLUTION NMR
主引用文献A pH-Responsive Topological Switch Based on a DNA Quadruplex-Duplex Hybrid.
Chemistry, 30, 2024
8R6D
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A quadruplex-duplex hybrid with a three-layered hybrid-2 G-quadruplex topology
分子名称: DNA (31-MER)
著者Vianney, Y.M, Weisz, K.
登録日2023-11-22
公開日2024-03-06
最終更新日2024-07-10
実験手法SOLUTION NMR
主引用文献Structural Differences at Quadruplex-Duplex Interfaces Enable Ligand-Induced Topological Transitions.
Adv Sci, 11, 2024
8RW2
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Structure of a chair-type antiparallel quadruplex-duplex hybrid at pH 6
分子名称: DNA (33-MER)
著者Vianney, Y.M, Weisz, K.
登録日2024-02-02
公開日2024-03-27
最終更新日2024-06-05
実験手法SOLUTION NMR
主引用文献A pH-Responsive Topological Switch Based on a DNA Quadruplex-Duplex Hybrid.
Chemistry, 30, 2024
8R6G
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A quadruplex-duplex hybrid with a three-layered chair G-quadruplex topology
分子名称: DNA (33-MER)
著者Vianney, Y.M, Weisz, K.
登録日2023-11-22
公開日2024-03-13
最終更新日2024-07-10
実験手法SOLUTION NMR
主引用文献Structural Differences at Quadruplex-Duplex Interfaces Enable Ligand-Induced Topological Transitions.
Adv Sci, 11, 2024
8F60
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BU of 8f60 by Molmil
anti-BTLA monoclonal antibody r23C8 in complex with BTLA
分子名称: ACETATE ION, B- and T-lymphocyte attenuator, alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Hendle, J, Atwell, S, Lieu, R, Hickey, M, Weichert, K.
登録日2022-11-15
公開日2023-05-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA.
Structure, 31, 2023
8F6O
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anti-BTLA monoclonal antibody h22B3 in complex with BTLA
分子名称: B- and T-lymphocyte attenuator, h22B3 Fab heavy chain, h22B3 Fab light chain
著者Hendle, J, Atwell, S, Lieu, R, Hickey, M, Weichert, K.
登録日2022-11-16
公開日2023-05-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA.
Structure, 31, 2023
8F6L
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anti-BTLA monoclonal antibody h25F7 in complex with BTLA
分子名称: B- and T-lymphocyte attenuator, h25F7 Fab heavy chain, h25F7 Fab light chain
著者Hendle, J, Atwell, S, Lieu, R, Hickey, M, Weichert, K.
登録日2022-11-16
公開日2023-05-24
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Epitope topography of agonist antibodies to the checkpoint inhibitory receptor BTLA.
Structure, 31, 2023
6U07
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BU of 6u07 by Molmil
Computational Stabilization of T Cell Receptor Constant Domains
分子名称: MAGNESIUM ION, Stabilized T cell receptor constant domain (Calpha), Stabilized T cell receptor constant domain (Cbeta)
著者Froning, K, Maguire, J, Sereno, A, Huang, F, Chang, S, Weichert, K, Frommelt, A.J, Dong, J, Wu, X, Austin, H, Conner, E.M, Fitchett, J.R, Heng, A.R, Balasubramaniam, D, Hilgers, M.T, Kuhlman, B, Demarest, S.J.
登録日2019-08-13
公開日2020-04-15
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Computational stabilization of T cell receptors allows pairing with antibodies to form bispecifics.
Nat Commun, 11, 2020
5KN5
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TGFalpha/Epiregulin complex with neutralizing antibody LY3016859
分子名称: Epiregulin Antibody LY3016859 Fab Heavy Chain, Epiregulin Antibody LY3016859 Fab Light Chain, Protransforming growth factor alpha, ...
著者Atwell, S, Boyles, J.S, Clawson, D.K, Druzina, Z, Josef, G.H, Weichert, K, Witcher, D.R.
登録日2016-06-27
公開日2016-08-31
最終更新日2016-11-02
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Structural basis of selectivity and neutralizing activity of a TGF alpha /epiregulin specific antibody.
Protein Sci., 25, 2016
6R9K
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A quadruplex hybrid structure with lpp loop orientation and 3 syn residues
分子名称: DNA (25-MER)
著者Karg, B, Weisz, K.
登録日2019-04-03
公開日2019-07-03
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Duplex-Guided Refolding into Novel G-Quadruplex (3+1) Hybrid Conformations.
Angew.Chem.Int.Ed.Engl., 58, 2019
6R9L
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A quadruplex hybrid structure with lpp loop orientation and 5 syn residues
分子名称: DNA (25-MER)
著者Karg, B, Weisz, K.
登録日2019-04-03
公開日2019-07-03
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Duplex-Guided Refolding into Novel G-Quadruplex (3+1) Hybrid Conformations.
Angew.Chem.Int.Ed.Engl., 58, 2019
6EZD
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BU of 6ezd by Molmil
Pyrrolysyl-tRNA synthetase from Canditatus Methanomethylophilus alvus (MmaPylRS)
分子名称: Pyrrolysyl-tRNA synthetase
著者Pavkov-Keller, T, Schweiger, K, Gruber, K.
登録日2017-11-15
公開日2018-12-12
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献A new archaeal pyrrolysyl-tRNA synthetase/amber suppressor tRNA pair for orthogonal protein translation
to be published
1H2O
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SOLUTION STRUCTURE OF THE MAJOR CHERRY ALLERGEN PRU AV 1 MUTANT E45W
分子名称: MAJOR ALLERGEN PRU AV 1
著者Neudecker, P, Lehmann, K, Nerkamp, J, Schweimer, K, Sticht, H, Boehm, M, Scheurer, S, Vieths, S, Roesch, P.
登録日2002-08-12
公開日2003-08-28
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Mutational Epitope Analysis of Pru Av 1 and Api G 1, the Major Allergens of Cherry (Prunus Avium) and Celery (Apium Graveolens): Correlating Ige Reactivity with Three-Dimensional Structure
Biochem.J., 376, 2003
8TCE
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Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3353871
分子名称: (2S)-3-phenyl-2-[(3R)-pyrrolidin-3-yl]propanoic acid, Apolipoprotein(a)
著者Hendle, J, Weichert, K, Sauder, J.M.
登録日2023-06-30
公開日2024-05-08
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.07 Å)
主引用文献Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024
7O1H
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Hybrid-2R quadruplex-duplex with (-p-p-l) topology and 3 syn residues
分子名称: DNA (31-MER)
著者Mohr, S, Vianney, Y.M, Weisz, K.
登録日2021-03-29
公開日2021-05-19
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献Expanding the Topological Landscape by a G-Column Flip of a Parallel G-Quadruplex.
Chemistry, 27, 2021
8V8Z
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Lipoprotein(a) Kringle IV domain 8 - Lp(a) KIV8 in complex with LY3473329
分子名称: Apolipoprotein(a), muvalaplin
著者Hendle, J, Weichert, K, Sauder, J.M.
登録日2023-12-06
公開日2024-05-08
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Discovery of potent small-molecule inhibitors of lipoprotein(a) formation.
Nature, 629, 2024

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