5DLR
| Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a triaryl-ethylene compound 4,4'-(2-phenylethene-1,1-diyl)diphenol | Descriptor: | 4,4'-(2-phenylethene-1,1-diyl)diphenol, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | Deposit date: | 2015-09-07 | Release date: | 2016-05-04 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.26 Å) | Cite: | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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5DK9
| Crystal Structure of the ER-alpha Ligand-binding Domain in complex with a phenylamino-substituted ethyl triaryl-ethylene derivative 4,4'-{2-[3-(phenylamino)phenyl]but-1-ene-1,1-diyl}diphenol | Descriptor: | 4,4'-{2-[3-(phenylamino)phenyl]but-1-ene-1,1-diyl}diphenol, Estrogen receptor, Nuclear receptor coactivator 2 | Authors: | Nwachukwu, J.C, Srinivasan, S, Zheng, Y, Wang, S, Min, J, Dong, C, Liao, Z, Cavett, V, Nowak, J, Houtman, R, Carlson, K.E, Josan, J.S, Elemento, O, Katzenellenbogen, J.A, Zhou, H.B, Nettles, K.W. | Deposit date: | 2015-09-03 | Release date: | 2016-05-04 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Predictive features of ligand-specific signaling through the estrogen receptor. Mol.Syst.Biol., 12, 2016
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1JPX
| Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac envelope glycoprotein complex. Wild type. | Descriptor: | gp41 envelope protein | Authors: | Liu, J, Wang, S, LaBranche, C.C, Hoxie, J.A, Lu, M. | Deposit date: | 2001-08-03 | Release date: | 2002-04-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex. J.Biol.Chem., 277, 2002
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7N3P
| Cryo-EM structure of the Cas12k-sgRNA-dsDNA complex | Descriptor: | Cas12k, DNA (5'-D(*CP*AP*TP*GP*AP*CP*TP*TP*CP*TP*CP*AP*AP*CP*CP*GP*AP*GP*TP*TP*T)-3'), DNA (5'-D(P*AP*AP*AP*CP*TP*CP*GP*GP*TP*T)-3'), ... | Authors: | Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. | Deposit date: | 2021-06-01 | Release date: | 2021-09-01 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.65 Å) | Cite: | Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition. Mol.Cell, 81, 2021
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7N3O
| Cryo-EM structure of the Cas12k-sgRNA complex | Descriptor: | Cas12k, Single guide RNA | Authors: | Chang, L, Li, Z, Xiao, R, Wang, S, Han, R. | Deposit date: | 2021-06-01 | Release date: | 2021-09-01 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural basis of target DNA recognition by CRISPR-Cas12k for RNA-guided DNA transposition. Mol.Cell, 81, 2021
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1RHT
| 24-MER RNA HAIRPIN COAT PROTEIN BINDING SITE FOR BACTERIOPHAGE R17 (NMR, MINIMIZED AVERAGE STRUCTURE) | Descriptor: | RNA (5'-R(P*GP*GP*GP*AP*CP*UP*GP*AP*CP*GP*AP*UP*CP*AP*CP*GP*CP*AP*GP*UP*CP*UP*AP*U)-3') | Authors: | Borer, P.N, Lin, Y, Wang, S, Roggenbuck, M.W, Gott, J.M, Uhlenbeck, O.C, Pelczer, I. | Deposit date: | 1995-03-03 | Release date: | 1995-06-03 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Proton NMR and structural features of a 24-nucleotide RNA hairpin. Biochemistry, 34, 1995
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5UK6
| Structure of Anabaena Sensory Rhodopsin Determined by Solid State NMR Spectroscopy and DEER | Descriptor: | Bacteriorhodopsin | Authors: | Milikisiyants, S, Wang, S, Munro, R.A, Donohue, M, Ward, M.E, Brown, L.S, Smirnova, T.I, Ladizhansky, V, Smirnov, A.I. | Deposit date: | 2017-01-20 | Release date: | 2017-05-31 | Last modified: | 2020-01-08 | Method: | SOLID-STATE NMR | Cite: | Oligomeric Structure of Anabaena Sensory Rhodopsin in a Lipid Bilayer Environment by Combining Solid-State NMR and Long-range DEER Constraints. J. Mol. Biol., 429, 2017
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1YJV
| Solution structure of the Cu(I) form of the sixth soluble domain of Menkes protein | Descriptor: | COPPER (I) ION, Copper-transporting ATPase 1 | Authors: | Banci, L, Bertini, I, Cantini, F, Migliardi, M, Rosato, A, Wang, S. | Deposit date: | 2005-01-15 | Release date: | 2006-01-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | An atomic-level investigation of the disease-causing A629P mutant of the Menkes protein, ATP7A J.Mol.Biol., 352, 2005
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1YJU
| Solution structure of the apo form of the sixth soluble domain of Menkes protein | Descriptor: | Copper-transporting ATPase 1 | Authors: | Banci, L, Bertini, I, Cantini, F, Migliardi, M, Rosato, A, Wang, S, Structural Proteomics in Europe (SPINE) | Deposit date: | 2005-01-15 | Release date: | 2006-01-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | An atomic-level investigation of the disease-causing A629P mutant of the Menkes protein, ATP7A J.Mol.Biol., 352, 2005
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1YJT
| Solution structure of the Cu(I) form of the sixth soluble domain A69P mutant of Menkes protein | Descriptor: | COPPER (I) ION, Copper-transporting ATPase 1 | Authors: | Banci, L, Bertini, I, Cantini, F, Migliardi, M, Rosato, A, Wang, S. | Deposit date: | 2005-01-15 | Release date: | 2006-01-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | An atomic-level investigation of the disease-causing A629P mutant of the Menkes protein, ATP7A J.Mol.Biol., 352, 2005
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1YJR
| Solution structure of the apo form of the sixth soluble domain A69P mutant of Menkes protein | Descriptor: | Copper-transporting ATPase 1 | Authors: | Banci, L, Bertini, I, Cantini, F, Migliardi, M, Rosato, A, Wang, S, Structural Proteomics in Europe (SPINE) | Deposit date: | 2005-01-15 | Release date: | 2006-01-03 | Last modified: | 2024-05-29 | Method: | SOLUTION NMR | Cite: | An atomic-level investigation of the disease-causing A629P mutant of the Menkes protein, ATP7A J.Mol.Biol., 352, 2005
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1JQ0
| Mutation that destabilize the gp41 core: determinants for stabilizing the SIV/CPmac envelope glycoprotein complex. Mutant structure. | Descriptor: | gp41 envelope protein | Authors: | Liu, J, Wang, S, LaBranche, C.C, Hoxie, J.A, Lu, M. | Deposit date: | 2001-08-03 | Release date: | 2002-04-24 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Mutations that destabilize the gp41 core are determinants for stabilizing the simian immunodeficiency virus-CPmac envelope glycoprotein complex. J.Biol.Chem., 277, 2002
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5WSO
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2AV9
| Crystal Structure of the PA5185 protein from Pseudomonas Aeruginosa Strain PAO1. | Descriptor: | SULFATE ION, Thioesterase | Authors: | Chruszcz, M, Wang, S, Cymborowski, M, Kudritska, M, Evdokimova, E, Edwards, A, Savchenko, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2005-08-29 | Release date: | 2005-10-18 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Function-biased choice of additives for optimization of protein crystallization - the case of the putative thioesterase PA5185 from Pseudomonas aeruginosa PAO1. Cryst.Growth Des., 8, 2008
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1SFK
| Core (C) protein from West Nile Virus, subtype Kunjin | Descriptor: | CALCIUM ION, CHLORIDE ION, Core protein, ... | Authors: | Dokland, T, Walsh, M, Mackenzie, J.M, Khromykh, A.A, Ee, K.-H, Wang, S. | Deposit date: | 2004-02-19 | Release date: | 2004-08-09 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | West nile virus core protein; tetramer structure and ribbon formation Structure, 12, 2004
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3H3M
| Crystal structure of flagellar protein FliT from Bordetella bronchiseptica | Descriptor: | Flagellar protein FliT, UNKNOWN | Authors: | Shumilin, I.A, Wang, S, Chruszcz, M, Xu, X, Le, B, Cui, H, Savchenko, A, Edwards, A.M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-04-16 | Release date: | 2009-04-28 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of flagellar protein FliT from Bordetella bronchiseptica To be Published
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3QYC
| Structure of a dimeric anti-HER2 single domain antibody | Descriptor: | VH domain of IgG molecule | Authors: | Baral, T.N, Chao, S, Li, S, Tanha, J, Arbabai, M, Wang, S, Zhang, J. | Deposit date: | 2011-03-03 | Release date: | 2012-02-08 | Last modified: | 2014-02-05 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Crystal Structure of a Human Single Domain Antibody Dimer Formed through V(H)-V(H) Non-Covalent Interactions. Plos One, 7, 2012
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4KC2
| Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate | Descriptor: | 6-(1-beta-D-Galactopyranosyloxymethyl)-N-(5'-deoxyluridine-5'-yl)picolinamide, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase soluble form, MANGANESE (II) ION, ... | Authors: | Cuesta-Seijo, J.A, Wang, S, Lafont, D, Vidal, S, Palcic, M.M. | Deposit date: | 2013-04-24 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Design of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogate. Chemistry, 19, 2013
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6UTU
| Crystal structure of minor pseudopilin ternary complex of XcpVWX from the Type 2 secretion system of Pseudomonas aeruginosa in the P3 space group | Descriptor: | CALCIUM ION, Type II secretion system protein I, Type II secretion system protein J, ... | Authors: | Zhang, Y, Wang, S, Jia, Z. | Deposit date: | 2019-10-30 | Release date: | 2020-09-02 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | In Situ Proteolysis Condition-Induced Crystallization of the XcpVWX Complex in Different Lattices. Int J Mol Sci, 21, 2020
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7XJF
| Crystal structure of 6MW3211 Fab in complex with CD47 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Wang, J, Wang, R, Jiao, S, Wang, S, Zhang, J, Zhang, M, Wang, M. | Deposit date: | 2022-04-16 | Release date: | 2023-05-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Blockade of dual immune checkpoint inhibitory signals with a CD47/PD-L1 bispecific antibody for cancer treatment. Theranostics, 13, 2023
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4KC1
| Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate | Descriptor: | 6-(1-beta-D-Glucopyranosyloxymethyl)-N-(5'-deoxyluridine-5'-yl)picolinamide, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, MANGANESE (II) ION, ... | Authors: | Cuesta-Seijo, J.A, Wang, S, Lafont, D, Vidal, S, Palcic, M.M. | Deposit date: | 2013-04-24 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Design of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogate. Chemistry, 19, 2013
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4KC4
| Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate | Descriptor: | 5'-deoxy-5'-[({6-[(alpha-D-galactopyranosyloxy)methyl]pyridin-2-yl}carbonyl)amino]uridine, Fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase, MANGANESE (II) ION, ... | Authors: | Cuesta-Seijo, J.A, Wang, S, Lafont, D, Vidal, S, Palcic, M.M. | Deposit date: | 2013-04-24 | Release date: | 2013-09-11 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Design of glycosyltransferase inhibitors: pyridine as a pyrophosphate surrogate. Chemistry, 19, 2013
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4GM8
| Crystal structure of human WD repeat domain 5 with compound MM-102 | Descriptor: | MM-102, WD repeat-containing protein 5 | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | Deposit date: | 2012-08-15 | Release date: | 2013-07-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.601 Å) | Cite: | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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4GM9
| Crystal structure of human WD repeat domain 5 with compound MM-401 | Descriptor: | MM-401, WD repeat-containing protein 5 | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Liu, L, Dou, Y, Lei, M, Wang, S. | Deposit date: | 2012-08-15 | Release date: | 2014-02-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of human WD repeat domain 5 with compound MM-401 To be Published
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4GM3
| Crystal structure of human WD repeat domain 5 with compound MM-101 | Descriptor: | MM-101, WD repeat-containing protein 5 | Authors: | Karatas, H, Townsend, E.C, Chen, Y, Bernard, D, Cao, F, Liu, L, Lei, M, Dou, Y, Wang, S. | Deposit date: | 2012-08-15 | Release date: | 2013-07-31 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (3.393 Å) | Cite: | High-affinity, small-molecule peptidomimetic inhibitors of MLL1/WDR5 protein-protein interaction. J.Am.Chem.Soc., 135, 2013
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