4TPT
Crystal Structure of the Human LIMK2 Kinase Domain In Complex With a Non-ATP Competitive Inhibitor
Summary for 4TPT
Entry DOI | 10.2210/pdb4tpt/pdb |
Descriptor | LIM domain kinase 2, N-{4-[(1S)-1,2-dihydroxyethyl]benzyl}-N-methyl-4-(phenylsulfamoyl)benzamide (3 entities in total) |
Functional Keywords | limk2 kinase, dfg inhibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Isoform LIMK2a: Cytoplasm. Isoform LIMK2b: Cytoplasm: P53671 |
Total number of polymer chains | 2 |
Total formula weight | 70043.89 |
Authors | Goodwin, N.C.,Cianchetta, G.,Hamman, B.L.,Burgoon, H.A.,Healy, J.,Mabon, S.,Strobel, E.D.,Wang, S.,Rawlins, D.B. (deposition date: 2014-06-09, release date: 2014-10-22, Last modification date: 2023-12-27) |
Primary citation | Goodwin, N.C.,Cianchetta, G.,Burgoon, H.A.,Healy, J.,Mabon, R.,Strobel, E.D.,Allen, J.,Wang, S.,Hamman, B.D.,Rawlins, D.B. Discovery of a Type III Inhibitor of LIM Kinase 2 That Binds in a DFG-Out Conformation. Acs Med.Chem.Lett., 6:53-57, 2015 Cited by PubMed: 25589930DOI: 10.1021/ml500242y PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
Download full validation report