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PDB: 1090 件
7K0O
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 3
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2021-03-24
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0K
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa, 3KS-bound
分子名称: 3-Dehydrosphinganine, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2021-03-24
実験手法ELECTRON MICROSCOPY (2.6 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0N
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 2
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2021-03-24
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0J
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa protomer
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2021-03-24
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0Q
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, myriocin-bound
分子名称: Myriocin, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0L
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa, myriocin-bound
分子名称: Myriocin, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0P
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 4
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2021-03-24
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0M
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Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa/ORMDL3, class 1
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, ORM1-like protein 3, PYRIDOXAL-5'-PHOSPHATE, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2021-03-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7K0I
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BU of 7k0i by Molmil
Human serine palmitoyltransferase complex SPTLC1/SPLTC2/ssSPTa
分子名称: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, PYRIDOXAL-5'-PHOSPHATE, Serine palmitoyltransferase 1, ...
著者Wang, Y, Niu, Y, Zhang, Z, Zhao, H, Myasnikov, A, Kalathur, R, Lee, C.H.
登録日2020-09-04
公開日2021-02-24
最終更新日2021-03-24
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献Structural insights into the regulation of human serine palmitoyltransferase complexes.
Nat.Struct.Mol.Biol., 28, 2021
7N19
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DR3 in complex with Aspergillus nidulans NAD-dependent histone deacetylase hst4 peptide
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Wang, Y, Dai, S.
登録日2021-05-27
公開日2021-08-18
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.38 Å)
主引用文献CD4+ T cells in the lungs of acute sarcoidosis patients recognize an Aspergillus nidulans epitope.
J.Exp.Med., 218, 2021
3K5Y
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Crystal structure of FBF-2/gld-1 FBEa complex
分子名称: 5'-R(*UP*GP*UP*GP*CP*CP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T.
登録日2009-10-08
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
4EEV
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BU of 4eev by Molmil
Crystal structure of c-Met in complex with LY2801653
分子名称: Hepatocyte growth factor receptor, N-(3-fluoro-4-{[1-methyl-6-(1H-pyrazol-4-yl)-1H-indazol-5-yl]oxy}phenyl)-1-(4-fluorophenyl)-6-methyl-2-oxo-1,2-dihydropyridine-3-carboxamide
著者Wang, Y, Stout, S.L.
登録日2012-03-28
公開日2013-04-10
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献LY2801653 is an orally bioavailable multi-kinase inhibitor with potent activity against MET, MST1R, and other oncoproteins, and displays anti-tumor activities in mouse xenograft models.
Invest New Drugs, 31, 2013
3K61
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Crystal structure of FBF-2/fog-1 FBEa complex
分子名称: 5'-R(*UP*GP*UP*AP*AP*AP*AP*UP*C)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T.
登録日2009-10-08
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.21 Å)
主引用文献Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
3K62
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Crystal structure of FBF-2/gld-1 FBEb complex
分子名称: 5'-R(*UP*GP*UP*GP*UP*UP*AP*UP*C)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T.
登録日2009-10-08
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
3DLB
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BU of 3dlb by Molmil
Crystal structure of the guide-strand-containing Argonaute protein silencing complex
分子名称: DNA (5'-D(*DTP*DGP*DAP*DGP*DGP*DTP*DAP*DGP*DTP*DA)-3'), argonaute
著者Wang, Y, Sheng, G, Patel, D.J.
登録日2008-06-26
公開日2008-09-02
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of the guide-strand-containing argonaute silencing complex.
Nature, 456, 2008
4P6G
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Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor.
分子名称: (3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl methylcarbamate, Cathepsin S
著者Wang, Y, Jadhav, P.K.
登録日2014-03-24
公開日2014-10-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.
Acs Med.Chem.Lett., 5, 2014
5FNV
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BU of 5fnv by Molmil
a new complex structure of tubulin with an alpha-beta unsaturated lactone
分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ...
著者Wang, Y, Naismith, J, Zhu, X.
登録日2015-11-16
公開日2016-05-18
最終更新日2024-10-23
実験手法X-RAY DIFFRACTION (2.61 Å)
主引用文献Pironetin Reacts Covalently with Cysteine-316 of Alpha-Tubulin to Destabilize Microtubule.
Nat.Commun., 7, 2016
3K64
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Crystal structure of FBF-2/fem-3 PME complex
分子名称: 5'-R(*UP*GP*UP*GP*UP*CP*AP*UP*U)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T.
登録日2009-10-08
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
3K5Q
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Crystal structure of FBF-2/FBE complex
分子名称: 5'-R(P*UP*GP*UP*AP*CP*UP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T.
登録日2009-10-07
公開日2009-11-03
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
3K5Z
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BU of 3k5z by Molmil
Crystal structure of FBF-2/gld-1 FBEa G4A mutant complex
分子名称: 5'-R(*UP*GP*UP*AP*CP*CP*AP*UP*A)-3', Fem-3 mRNA-binding factor 2
著者Wang, Y, Opperman, L, Wickens, M, Hall, T.M.T.
登録日2009-10-08
公開日2009-11-03
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural basis for specific recognition of multiple mRNA targets by a PUF regulatory protein.
Proc.Natl.Acad.Sci.USA, 106, 2009
3B45
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Crystal structure of GlpG at 1.9A resolution
分子名称: glpG, nonyl beta-D-glucopyranoside
著者Wang, Y, Maegawa, S, Akiyama, Y, Ha, Y.
登録日2007-10-23
公開日2008-01-22
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The role of L1 loop in the mechanism of rhomboid intramembrane protease GlpG.
J.Mol.Biol., 374, 2007
4X3P
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BU of 4x3p by Molmil
Sirt2 in complex with a myristoyl peptide
分子名称: 1,2-ETHANEDIOL, CARBA-NICOTINAMIDE-ADENINE-DINUCLEOTIDE, NAD-dependent protein deacetylase sirtuin-2, ...
著者Wang, Y, Zhang, W, Hao, Q.
登録日2014-12-01
公開日2016-01-13
最終更新日2024-11-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Deacylation Mechanism by SIRT2 Revealed in the 1'-SH-2'-O-Myristoyl Intermediate Structure.
Cell Chem Biol, 24, 2017
8HBS
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BU of 8hbs by Molmil
Crystal of rAlfNmt
分子名称: Glycylpeptide N-tetradecanoyltransferase
著者Wang, Y, Wang, S.
登録日2022-10-30
公開日2023-03-08
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献N -Myristoyltransferase, a Potential Antifungal Candidate Drug-Target for Aspergillus flavus.
Microbiol Spectr, 11, 2023
3HM9
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Crystal structure of T. thermophilus Argonaute complexed with DNA guide strand and 19-nt RNA target strand
分子名称: 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ...
著者Wang, Y, Li, H, Sheng, G, Patel, D.J.
登録日2009-05-28
公開日2009-10-06
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009
3HXM
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Structure of an argonaute complexed with guide DNA and target RNA duplex containing two mismatches.
分子名称: Argonaute, DNA (5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3'), MAGNESIUM ION, ...
著者Wang, Y, Li, H, Sheng, G, Patel, D.J.
登録日2009-06-21
公開日2009-10-06
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes.
Nature, 461, 2009

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