3ZIF
 
 | | Cryo-EM structures of two intermediates provide insight into adenovirus assembly and disassembly | | Descriptor: | HEXON PROTEIN, PENTON PROTEIN, PIX, ... | | Authors: | Cheng, L, Huang, X, Li, X, Xiong, W, Sun, W, Yang, C, Zhang, K, Wang, Y, Liu, H, Ji, G, Sun, F, Zheng, C, Zhu, P. | | Deposit date: | 2013-01-09 | | Release date: | 2014-01-22 | | Last modified: | 2024-05-08 | | Method: | ELECTRON MICROSCOPY (4.5 Å) | | Cite: | Cryo-Em Structures of Two Bovine Adenovirus Type 3 Intermediates
Virology, 450, 2014
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6QGH
 | | Structure of human Bcl-2 in complex with ABT-263 | | Descriptor: | 4-(4-{[2-(4-chlorophenyl)-5,5-dimethylcyclohex-1-en-1-yl]methyl}piperazin-1-yl)-N-[(4-{[(2R)-4-(morpholin-4-yl)-1-(phenylsulfanyl)butan-2-yl]amino}-3-[(trifluoromethyl)sulfonyl]phenyl)sulfonyl]benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1 | | Authors: | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | Deposit date: | 2019-01-11 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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6QGJ
 | | Structure of human Bcl-2 in complex with fragment/ABT-263 hybrid | | Descriptor: | 4-[4-[(1~{R})-1-(6-methoxy-1,3-benzodioxol-5-yl)-2-pyrrolidin-1-yl-ethyl]phenyl]-~{N}-[4-[[(2~{R})-4-morpholin-4-yl-1-phenylsulfanyl-butan-2-yl]amino]-3-(trifluoromethylsulfonyl)phenyl]sulfonyl-benzamide, Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1 | | Authors: | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | Deposit date: | 2019-01-11 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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6QFI
 | | Structure of human Mcl-1 in complex with BIM BH3 peptide | | Descriptor: | Bcl-2-like protein 11, Induced myeloid leukemia cell differentiation protein Mcl-1, ZINC ION | | Authors: | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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6QFQ
 | | Structure of human Mcl-1 in complex with indole acid inhibitor | | Descriptor: | 7-(3,5-dimethyl-1~{H}-pyrazol-4-yl)-3-(3-naphthalen-1-yloxypropyl)-1~{H}-indole-2-carboxylic acid, Induced myeloid leukemia cell differentiation protein Mcl-1 | | Authors: | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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6QG8
 | | Structure of human Bcl-2 in complex with PUMA BH3 peptide | | Descriptor: | Apoptosis regulator Bcl-2,Bcl-2-like protein 1,Apoptosis regulator Bcl-2,Bcl-2-like protein 1, Bcl-2-binding component 3 | | Authors: | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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6QFM
 | | Structure of human Mcl-1 in complex with PUMA BH3 peptide | | Descriptor: | Bcl-2-binding component 3, CHLORIDE ION, Induced myeloid leukemia cell differentiation protein Mcl-1, ... | | Authors: | Dokurno, P, Murray, J, Davidson, J, Chen, I, Davis, B, Graham, C.J, Harris, R, Jordan, A.M, Matassova, N, Pedder, C, Ray, S, Roughley, S, Smith, J, Walmsley, C, Wang, Y, Whitehead, N, Williamson, D.S, Casara, P, Le Diguarher, T, Hickman, J, Stark, J, Kotschy, A, Geneste, O, Hubbard, R.E. | | Deposit date: | 2019-01-10 | | Release date: | 2019-06-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Establishing Drug Discovery and Identification of Hit Series for the Anti-apoptotic Proteins, Bcl-2 and Mcl-1.
Acs Omega, 4, 2019
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7V5K
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1) | | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-17 | | Release date: | 2022-08-24 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722 (state 1)
to be published
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8JDI
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8JDH
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7V5J
 | | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2) | | Descriptor: | 0722 H, 0722 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-17 | | Release date: | 2022-09-21 | | Method: | ELECTRON MICROSCOPY (2.8 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 0722(state 2)
to be published
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1GGP
 | | CRYSTAL STRUCTURE OF TRICHOSANTHES KIRILOWII LECTIN-1 AND ITS RELATION TO THE TYPE 2 RIBOSOME INACTIVATING PROTEINS | | Descriptor: | PROTEIN (LECTIN 1 A CHAIN), PROTEIN (LECTIN 1 B CHAIN) | | Authors: | Li, M, Chai, J.J, Wang, Y.P, Wang, K.Y, Bi, R.C. | | Deposit date: | 2000-09-07 | | Release date: | 2003-03-18 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal Structure of Trichosanthes Kirilowii Lectin-1 and its Relation to the Type 2 Ribosome Inactivating Proteins
PROTEIN PEPT.LETT., 8, 2003
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7V6N
 | | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1 | | Descriptor: | 111 H, 111 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-20 | | Release date: | 2022-09-14 | | Last modified: | 2024-10-16 | | Method: | ELECTRON MICROSCOPY (3.99 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 state1
to be published
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7V6O
 | | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2) | | Descriptor: | 111 H, 111 L, Spike glycoprotein | | Authors: | Wang, X, Zhao, J, Wang, Z, Zeng, J, Zhang, S, Wang, Y. | | Deposit date: | 2021-08-20 | | Release date: | 2022-09-28 | | Last modified: | 2024-10-09 | | Method: | ELECTRON MICROSCOPY (4.56 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 111 (state 2)
to be published
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7V3L
 | | MERS S ectodomain trimer in complex with neutralizing antibody 6516 | | Descriptor: | Spike glycoprotein, antibody H, antibody L | | Authors: | Wang, X, Zhao, J, Wang, Z, Wang, Y, Zeng, J. | | Deposit date: | 2021-08-10 | | Release date: | 2022-08-17 | | Last modified: | 2024-10-30 | | Method: | ELECTRON MICROSCOPY (3.47 Å) | | Cite: | MERS S ectodomain trimer in complex with neutralizing antibody 6516
to be published
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1I87
 | | SOLUTION STRUCTURE OF THE WATER-SOLUBLE FRAGMENT OF RAT HEPATIC APOCYTOCHROME B5 | | Descriptor: | CYTOCHROME B5 | | Authors: | Falzone, C.J, Wang, Y, Vu, B.C, Scott, N.L, Bhattacharya, S, Lecomte, J.T. | | Deposit date: | 2001-03-12 | | Release date: | 2001-05-16 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Structural and dynamic perturbations induced by heme binding in cytochrome b5.
Biochemistry, 40, 2001
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6IFN
 | | Crystal structure of Type III-A CRISPR Csm complex | | Descriptor: | MANGANESE (II) ION, RNA (32-MER), Type III-A CRISPR-associated RAMP protein Csm3, ... | | Authors: | You, L, Wang, J, Wang, Y. | | Deposit date: | 2018-09-20 | | Release date: | 2018-12-12 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference
Cell, 176, 2019
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4DZD
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2P01
 | | The structure of receptor-associated protein(RAP) | | Descriptor: | Alpha-2-macroglobulin receptor-associated protein | | Authors: | Lee, D, Walsh, J.D, Migliorini, M, Yu, P, Cai, T, Schwieters, C.D, Krueger, S, Strickland, D.K, Wang, Y.X. | | Deposit date: | 2007-02-28 | | Release date: | 2007-08-21 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | The structure of receptor-associated protein (RAP).
Protein Sci., 16, 2007
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4IFT
 | | Crystal structure of double mutant thermostable NPPase from Geobacillus stearothermophilus | | Descriptor: | Thermostable NPPase | | Authors: | Guo, Z, Huang, J, Wang, F, Qiu, R, Wang, Y, Ji, C. | | Deposit date: | 2012-12-15 | | Release date: | 2013-12-18 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.995 Å) | | Cite: | Crystal structure of thermostable NPPase from Geobacillus stearothermophilus
To be Published
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6PC4
 | | Tubulin-RB3_SLD-TTL in complex with compound ABI-274 | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Kumar, G, Wang, Y, Li, W, White, S.W. | | Deposit date: | 2019-06-15 | | Release date: | 2020-04-22 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.602 Å) | | Cite: | Structure-Activity Relationship Study of Novel 6-Aryl-2-benzoyl-pyridines as Tubulin Polymerization Inhibitors with Potent Antiproliferative Properties.
J.Med.Chem., 63, 2020
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4IG4
 | | Crystal structure of single mutant thermostable NPPase (N86S) from Geobacillus stearothermophilus | | Descriptor: | Thermostable NPPase | | Authors: | Guo, Z, Wang, F, Huang, J, Qiu, R, Yang, Z, Wang, Y, Gong, W, Ji, C. | | Deposit date: | 2012-12-16 | | Release date: | 2013-12-18 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.402 Å) | | Cite: | Crystal structure of thermostable NPPase from Geobacillus stearothermophilus
To be Published
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1PVZ
 | | Solution Structure of BmP07, A Novel Potassium Channel Blocker from Scorpion Buthus martensi Karsch, 15 structures | | Descriptor: | K+ toxin-like peptide | | Authors: | Wu, H, Zhang, N, Wang, Y, Zhang, Q, Ou, L, Li, M, Hu, G. | | Deposit date: | 2003-06-29 | | Release date: | 2004-05-18 | | Last modified: | 2018-06-20 | | Method: | SOLUTION NMR | | Cite: | Solution structure of BmKK2, a new potassium channel blocker from the venom of chinese scorpion Buthus martensi Karsch
PROTEINS, 55, 2004
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7N6T
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7MWX
 | | Structure of the core ectodomain of the hepatitis C virus envelope glycoprotein 2 with tamarin CD81 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2A12 Fab Heavy Chain, ... | | Authors: | Kumar, A, Hossain, R.A, Yost, S.A, Bu, W, Wang, Y, Dearborn, A.D, Grakoui, A, Cohen, J.I, Marcotrigiano, J. | | Deposit date: | 2021-05-17 | | Release date: | 2021-09-15 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (3.32 Å) | | Cite: | Structural insights into hepatitis C virus receptor binding and entry.
Nature, 598, 2021
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