4FJ4
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![BU of 4fj4 by Molmil](/molmil-images/mine/4fj4) | Crystal structure of the protein Q9HRE7 complexed with mercury from Halobacterium salinarium at the resolution 2.1A, Northeast Structural Genomics Consortium target HsR50 | Descriptor: | ETHYL MERCURY ION, SODIUM ION, Uncharacterized protein | Authors: | Kuzin, A, Chen, Y, Vorobiev, S.M, Seetharaman, J, Janjua, J, Xiao, R, Cunningham, K, Maglaqui, M, Owens, L.A, Wang, H, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2012-06-11 | Release date: | 2012-08-22 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Northeast Structural Genomics Consortium Target HsR50 To be Published
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1Q2I
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![BU of 1q2i by Molmil](/molmil-images/mine/1q2i) | NMR SOLUTION STRUCTURE OF A PEPTIDE FROM THE MDM-2 BINDING DOMAIN OF THE P53 PROTEIN THAT IS SELECTIVELY CYTOTOXIC TO CANCER CELLS | Descriptor: | PNC27 | Authors: | Rosal, R, Pincus, M.R, Brandt-Rauf, P.W, Fine, R.L, Wang, H. | Deposit date: | 2003-07-24 | Release date: | 2004-03-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells Biochemistry, 43, 2004
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3NGW
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![BU of 3ngw by Molmil](/molmil-images/mine/3ngw) | Crystal Structure of Molybdopterin-guanine dinucleotide biosynthesis protein A from Archaeoglobus fulgidus, Northeast Structural Genomics Consortium Target GR189 | Descriptor: | CALCIUM ION, Molybdopterin-guanine dinucleotide biosynthesis protein A (MobA) | Authors: | Forouhar, F, Neely, H, Seetharaman, J, Patel, P, Xiao, R, Ciccosanti, C, Wang, H, Everett, J.K, Nair, R, Acton, T.B, Rost, B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2010-06-13 | Release date: | 2010-08-11 | Last modified: | 2019-07-17 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Northeast Structural Genomics Consortium Target GR189 To be Published
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7DAC
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![BU of 7dac by Molmil](/molmil-images/mine/7dac) | Human RIPK3 amyloid fibril revealed by solid-state NMR | Descriptor: | Receptor-interacting serine/threonine-protein kinase 3 | Authors: | Wu, X.L, Zhang, J, Dong, X.Q, Liu, J, Li, B, Hu, H, Wang, J, Wang, H.Y, Lu, J.X. | Deposit date: | 2020-10-16 | Release date: | 2021-04-28 | Last modified: | 2024-05-01 | Method: | SOLID-STATE NMR | Cite: | The structure of a minimum amyloid fibril core formed by necroptosis-mediating RHIM of human RIPK3. Proc.Natl.Acad.Sci.USA, 118, 2021
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4YGQ
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![BU of 4ygq by Molmil](/molmil-images/mine/4ygq) | Crystal structure of HAD phosphatase from Thermococcus onnurineus | Descriptor: | Hydrolase, TERTIARY-BUTYL ALCOHOL | Authors: | Ngo, T.D, Le, B.V, Subramani, V.K, Nguyen, C.M.T, Lee, H.S, Cho, Y, Kim, K.K, Hwang, H.Y. | Deposit date: | 2015-02-26 | Release date: | 2015-04-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the substrate selectivity of a HAD phosphatase from Thermococcus onnurineus NA1 Biochem.Biophys.Res.Commun., 461, 2015
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7D0B
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![BU of 7d0b by Molmil](/molmil-images/mine/7d0b) | S protein of SARS-CoV-2 in complex bound with P5A-3C12_1B | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of P5A-3C12, ... | Authors: | Yan, R.H, Wang, R.K, Ju, B, Yu, J.F, Zhang, Y.Y, Liu, N, Wang, H.W, Wang, X.Q, Zhang, L.Q, Zhou, Q. | Deposit date: | 2020-09-09 | Release date: | 2021-03-10 | Last modified: | 2021-05-19 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis for bivalent binding and inhibition of SARS-CoV-2 infection by human potent neutralizing antibodies. Cell Res., 31, 2021
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4YGR
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![BU of 4ygr by Molmil](/molmil-images/mine/4ygr) | Crystal structure of HAD phosphatase from Thermococcus onnurineus | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Hydrolase, MAGNESIUM ION | Authors: | Ngo, T.D, Le, B.V, Subramani, V.K, Nguyen, C.M.T, Lee, H.S, Cho, Y, Kim, K.K, Hwang, H.Y. | Deposit date: | 2015-02-26 | Release date: | 2015-04-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.703 Å) | Cite: | Structural basis for the substrate selectivity of a HAD phosphatase from Thermococcus onnurineus NA1 Biochem.Biophys.Res.Commun., 461, 2015
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5WH6
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![BU of 5wh6 by Molmil](/molmil-images/mine/5wh6) | Crystal structure of PDE4D2 in complex with inhibitor (S_Zl-n-91) | Descriptor: | 1-[4-(difluoromethoxy)-3-{[(3S)-oxolan-3-yl]oxy}phenyl]-3-methylbutan-1-one, MAGNESIUM ION, ZINC ION, ... | Authors: | Ke, H, Wang, H. | Deposit date: | 2017-07-14 | Release date: | 2018-07-18 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Identification of a PDE4-Specific Pocket for the Design of Selective Inhibitors. Biochemistry, 57, 2018
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2KCT
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![BU of 2kct by Molmil](/molmil-images/mine/2kct) | Solution nmr structure of the ob-fold domain of heme chaperone ccme from desulfovibrio vulgaris. northeast structural genomics target dvr115g. | Descriptor: | Cytochrome c-type biogenesis protein CcmE | Authors: | Aramini, J.M, Rossi, P, Lee, H, Lemak, A, Wang, H, Foote, E.L, Jiang, M, Xiao, R, Nair, R, Swapna, G.V.T, Acton, T.B, Rost, B, Everett, J.K, Montelione, G.T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2008-12-29 | Release date: | 2009-02-10 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Solution nmr structure of the ob-fold domain of heme chaperone
ccme from desulfovibrio vulgaris. northeast structural genomics target dvr115g. To be Published
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1Q2F
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![BU of 1q2f by Molmil](/molmil-images/mine/1q2f) | NMR SOLUTION STRUCTURE OF A PEPTIDE FROM THE MDM-2 BINDING DOMAIN OF THE P53 PROTEIN THAT IS SELECTIVELY CYTOTOXIC TO CANCER CELLS | Descriptor: | PNC27 | Authors: | Rosal, R, Pincus, M.R, Brandt-Rauf, P.W, Fine, R.L, Wang, H. | Deposit date: | 2003-07-24 | Release date: | 2004-03-16 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | NMR solution structure of a peptide from the mdm-2 binding domain of the p53 protein that is selectively cytotoxic to cancer cells Biochemistry, 43, 2004
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4YGS
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![BU of 4ygs by Molmil](/molmil-images/mine/4ygs) | Crystal structure of HAD phosphatase from Thermococcus onnurineus | Descriptor: | CITRIC ACID, Hydrolase, MAGNESIUM ION | Authors: | Ngo, T.D, Le, B.V, Subramani, V.K, Nguyen, C.M.T, Lee, H.S, Cho, Y, Kim, K.K, Hwang, H.Y. | Deposit date: | 2015-02-26 | Release date: | 2015-04-22 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structural basis for the substrate selectivity of a HAD phosphatase from Thermococcus onnurineus NA1 Biochem.Biophys.Res.Commun., 461, 2015
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3G3N
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![BU of 3g3n by Molmil](/molmil-images/mine/3g3n) | PDE7A catalytic domain in complex with 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one | Descriptor: | 3-(2,6-difluorophenyl)-2-(methylthio)quinazolin-4(3H)-one, High affinity cAMP-specific 3',5'-cyclic phosphodiesterase 7A, MAGNESIUM ION, ... | Authors: | Castano, T, Wang, H. | Deposit date: | 2009-02-02 | Release date: | 2009-04-28 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Synthesis, structural analysis, and biological evaluation of thioxoquinazoline derivatives as phosphodiesterase 7 inhibitors Chemmedchem, 4, 2009
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5Z1Q
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![BU of 5z1q by Molmil](/molmil-images/mine/5z1q) | Crystal structures of the trimeric N-terminal domain of Ciliate Euplotes octocarinatus Centrin | Descriptor: | CALCIUM ION, CHLORIDE ION, Centrin protein | Authors: | Wang, W, Zhao, Y, Yang, B, Wang, H. | Deposit date: | 2017-12-27 | Release date: | 2018-04-25 | Last modified: | 2018-06-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the trimeric N-terminal domain of ciliate Euplotes octocarinatus centrin binding with calcium ions Protein Sci., 27, 2018
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2KO1
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![BU of 2ko1 by Molmil](/molmil-images/mine/2ko1) | Solution NMR structure of the ACT domain from GTP pyrophosphokinase of Chlorobium tepidum. Northeast Structural Genomics Consortium Target CtR148A | Descriptor: | GTP pyrophosphokinase | Authors: | Eletsky, A, Garcia, E, Wang, H, Ciccosanti, C, Jiang, M, Nair, R, Rost, B, Acton, T.B, Xiao, R, Everett, J.K, Lee, H, Prestegard, J.H, Montelione, G.T, Szyperski, T, Northeast Structural Genomics Consortium (NESG) | Deposit date: | 2009-09-08 | Release date: | 2009-09-29 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | Solution NMR structure of the ACT domain from GTP pyrophosphokinase of Chlorobium tepidum To be Published
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2CWE
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![BU of 2cwe by Molmil](/molmil-images/mine/2cwe) | Crystal structure of hypothetical transcriptional regulator protein, PH1932 from Pyrococcus horikoshii OT3 | Descriptor: | hypothetical transcription regulator protein, PH1932 | Authors: | Arai, R, Kishishita, S, Kukimoto-Niino, M, Wang, H, Sugawara, M, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2005-06-20 | Release date: | 2005-12-20 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Crystal structure of hypothetical transcriptional regulator protein, PH1932 from Pyrococcus horikoshii OT3 To be Published
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6K41
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![BU of 6k41 by Molmil](/molmil-images/mine/6k41) | cryo-EM structure of alpha2BAR-GoA complex | Descriptor: | 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K. | Deposit date: | 2019-05-23 | Release date: | 2020-04-15 | Last modified: | 2020-05-13 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine. Nat.Chem.Biol., 16, 2020
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6K42
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![BU of 6k42 by Molmil](/molmil-images/mine/6k42) | cryo-EM structure of alpha2BAR-Gi1 complex | Descriptor: | 4-[(1~{S})-1-(2,3-dimethylphenyl)ethyl]-1~{H}-imidazole, Alpha-2A adrenergic receptor,Endolysin,Alpha-2B adrenergic receptor,Alpha-2B adrenergic receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Yuan, D, Liu, Z, Wang, H.W, Kobilka, B.K. | Deposit date: | 2019-05-23 | Release date: | 2020-04-15 | Last modified: | 2020-05-13 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Activation of the alpha2Badrenoceptor by the sedative sympatholytic dexmedetomidine. Nat.Chem.Biol., 16, 2020
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2ZM6
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![BU of 2zm6 by Molmil](/molmil-images/mine/2zm6) | Crystal structure of the Thermus thermophilus 30S ribosomal subunit | Descriptor: | 16S ribosomal RNA, 30S ribosomal protein S10, 30S ribosomal protein S11, ... | Authors: | Kaminishi, T, Wang, H, Kawazoe, M, Ishii, R, Schluenzen, F, Hanawa-Suetsugu, K, Wilson, D.N, Nomura, M, Takemoto, C, Shirouzu, M, Fucini, P, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2008-04-11 | Release date: | 2009-04-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of the Thermus thermophilus 30S ribosomal subunit To be Published
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7EVP
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![BU of 7evp by Molmil](/molmil-images/mine/7evp) | Cryo-EM structure of the Gp168-beta-clamp complex | Descriptor: | Beta sliding clamp, Sliding clamp inhibitor | Authors: | Liu, B, Li, S, Liu, Y, Chen, H, Hu, Z, Wang, Z, Gou, L, Zhang, L, Ma, B, Wang, H, Matthews, S, Wang, Y, Zhang, K. | Deposit date: | 2021-05-21 | Release date: | 2022-02-16 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Bacteriophage Twort protein Gp168 is a beta-clamp inhibitor by occupying the DNA sliding channel. Nucleic Acids Res., 49, 2021
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7FH6
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![BU of 7fh6 by Molmil](/molmil-images/mine/7fh6) | Friedel-Crafts alkylation enzyme CylK | Descriptor: | CALCIUM ION, CHLORIDE ION, CylK, ... | Authors: | Liu, L, Wang, H.Q, Xiang, Z. | Deposit date: | 2021-07-29 | Release date: | 2022-02-16 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Basis for the Friedel-Crafts Alkylation in Cylindrocyclophane Biosynthesis ACS Catal., 12, 2022
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3TYH
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![BU of 3tyh by Molmil](/molmil-images/mine/3tyh) | Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae | Descriptor: | COPPER (II) ION, FbpA protein | Authors: | Chen, W.J, Wang, H.F, Zhou, C.J, Ye, D.R, Huang, J, Tan, X.S, Zhong, W.Q. | Deposit date: | 2011-09-26 | Release date: | 2012-09-26 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae To be Published
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4C5Y
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![BU of 4c5y by Molmil](/molmil-images/mine/4c5y) | Crystal structure of A. niger ochratoxinase | Descriptor: | OCHRATOXINASE, ZINC ION | Authors: | Dobritzsch, D, Wang, H, Schneider, G, Yu, S. | Deposit date: | 2013-09-17 | Release date: | 2014-07-02 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Structural and Functional Characterization of Ochratoxinase, a Novel Mycotoxin Degrading Enzyme. Biochem.J., 462, 2014
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2LG3
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![BU of 2lg3 by Molmil](/molmil-images/mine/2lg3) | Structure of the duplex containing HNE derived (6S,8R,11S) gamma-HO-PdG when placed opposite dT | Descriptor: | (4S)-nonane-1,4-diol, DNA (5'-D(*GP*CP*TP*AP*GP*CP*GP*AP*GP*TP*CP*C)-3'), DNA (5'-D(*GP*GP*AP*CP*TP*TP*GP*CP*TP*AP*GP*C)-3') | Authors: | Huang, H, Wang, H, Kozekova, A, Lloyd, R.S, Rizzo, C.J, Stone, M.P. | Deposit date: | 2011-07-19 | Release date: | 2012-08-01 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Ring-chain tautomerization of trans-4-hydroxynonenal derived (6S,8R,11S) gamma-hydroxy-1,N2-propano-deoxyguanosine adduct when placed opposite 2'-deoxythymidine in duplex To be Published
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8T8M
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![BU of 8t8m by Molmil](/molmil-images/mine/8t8m) | Quis-bound intermediate mGlu5 | Descriptor: | (S)-2-AMINO-3-(3,5-DIOXO-[1,2,4]OXADIAZOLIDIN-2-YL)-PROPIONIC ACID, Metabotropic glutamate receptor 5, Nb43 | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | Deposit date: | 2023-06-22 | Release date: | 2023-10-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Stepwise activation of a metabotropic glutamate receptor. Nature, 629, 2024
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8T6J
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![BU of 8t6j by Molmil](/molmil-images/mine/8t6j) | CDPPB-bound inactive mGlu5 | Descriptor: | 3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide, Metabotropic glutamate receptor 5 | Authors: | Krishna Kumar, K, Wang, H, Kobilka, B.K. | Deposit date: | 2023-06-16 | Release date: | 2023-10-11 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Stepwise activation of a metabotropic glutamate receptor. Nature, 629, 2024
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