8FTQ
 
 | | Crystal structure of hRpn13 Pru domain in complex with Ubiquitin and XL44 | | 分子名称: | N-(3-{[(3R)-5-fluoro-2-oxo-2,3-dihydro-1H-indol-3-yl]methyl}phenyl)-4-methoxybenzamide, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | | 著者 | Walters, K.J, Lu, X, Chandravanshi, M. | | 登録日 | 2023-01-13 | | 公開日 | 2024-03-27 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A structure-based designed small molecule depletes hRpn13 Pru and a select group of KEN box proteins.
Nat Commun, 15, 2024
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1J8C
 | | Solution Structure of the Ubiquitin-like Domain of hPLIC-2 | | 分子名称: | ubiquitin-like protein hPLIC-2 | | 著者 | Walters, K.J, Kleijnen, M.F, Goh, A.M, Wagner, G, Howley, P.M. | | 登録日 | 2001-05-21 | | 公開日 | 2002-03-20 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural studies of the interaction between ubiquitin family proteins and proteasome subunit S5a.
Biochemistry, 41, 2002
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1AJY
 | | STRUCTURE AND MOBILITY OF THE PUT3 DIMER: A DNA PINCER, NMR, 13 STRUCTURES | | 分子名称: | PUT3, ZINC ION | | 著者 | Walters, K.J, Dayie, K.T, Reece, R.J, Ptashne, M, Wagner, G. | | 登録日 | 1997-05-12 | | 公開日 | 1997-09-17 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and mobility of the PUT3 dimer.
Nat.Struct.Biol., 4, 1997
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1QZE
 | | HHR23a protein structure based on residual dipolar coupling data | | 分子名称: | UV excision repair protein RAD23 homolog A | | 著者 | Walters, K.J, Lech, P.J, Goh, A.M, Wang, Q, Howley, P.M. | | 登録日 | 2003-09-16 | | 公開日 | 2003-10-21 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a
Proc.Natl.Acad.Sci.USA, 100, 2003
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1CKV
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1OQY
 | | Structure of the DNA repair protein hHR23a | | 分子名称: | UV excision repair protein RAD23 homolog A | | 著者 | Walters, K.J, Lech, P.J, Goh, A.M, Wang, Q, Howley, P.M. | | 登録日 | 2003-03-11 | | 公開日 | 2003-10-21 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | DNA-repair protein hHR23a alters its protein structure upon binding proteasomal subunit S5a
Proc.Natl.Acad.Sci.USA, 100, 2003
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2R2Y
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6U19
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5IRS
 | | crystal structure of the proteasomal Rpn13 PRU-domain | | 分子名称: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, Proteasomal ubiquitin receptor ADRM1 | | 著者 | Chen, X, Shi, K, Walters, K, Aihara, H. | | 登録日 | 2016-03-14 | | 公開日 | 2016-07-20 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.796 Å) | | 主引用文献 | Structures of Rpn1 T1:Rad23 and hRpn13:hPLIC2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome.
Structure, 24, 2016
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8W2V
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5W77
 | | Solution structure of the MYC G-quadruplex bound to small molecule DC-34 | | 分子名称: | 4-[(azepan-1-yl)methyl]-5-hydroxy-2-methyl-N-[4-(trifluoromethyl)phenyl]-1-benzofuran-3-carboxamide, DNA (5'-D(*TP*GP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*GP*GP*GP*TP*GP*GP*GP*TP*AP*A)-3'), POTASSIUM ION | | 著者 | Chen, X, Walters, K.J. | | 登録日 | 2017-06-19 | | 公開日 | 2018-10-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Chemical and structural studies provide a mechanistic basis for recognition of the MYC G-quadruplex.
Nat Commun, 9, 2018
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6CO4
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7KXI
 | | Structure of XL5-ligated hRpn13 Pru domain | | 分子名称: | 2-{[(2S)-2-cyano-3-{3-[(4-methylbenzene-1-carbonyl)amino]phenyl}propanoyl]amino}benzoic acid, Proteasomal ubiquitin receptor ADRM1 | | 著者 | Lu, X, Walters, K.J. | | 登録日 | 2020-12-03 | | 公開日 | 2021-12-15 | | 最終更新日 | 2021-12-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.
Nat Commun, 12, 2021
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8GI6
 | | Crystal structure of RhoA mutant L69R complexed with GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA | | 著者 | Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J. | | 登録日 | 2023-03-13 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Ras-like GTPases mutant structures
To be published
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8GI3
 | | Crystal structure of RhoA mutant L69P complexed with GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA | | 著者 | Chen, X, Qian, X, Chandravanshi, M, Lowy, D.R, Walters, K.J. | | 登録日 | 2023-03-13 | | 公開日 | 2024-03-20 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | | 主引用文献 | Ras-like GTPases mutants structure
To be published
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2Z4D
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2Z59
 | | Complex Structures of Mouse Rpn13 (22-130aa) and ubiquitin | | 分子名称: | Protein ADRM1, Ubiquitin | | 著者 | Chen, X, Schreiner, P, Groll, M, Walters, K.J. | | 登録日 | 2007-07-01 | | 公開日 | 2008-05-20 | | 最終更新日 | 2024-05-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Ubiquitin docking at the proteasome through a novel pleckstrin-homology domain interaction.
Nature, 453, 2008
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6WJD
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6WJN
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6MUN
 | | Structure of hRpn10 bound to UBQLN2 UBL | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 4, Ubiquilin-2 | | 著者 | Chen, X, Walters, K.J. | | 登録日 | 2018-10-23 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of hRpn10 Bound to UBQLN2 UBL Illustrates Basis for Complementarity between Shuttle Factors and Substrates at the Proteasome.
J.Mol.Biol., 431, 2019
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6E5N
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6UYJ
 | | hRpn13:hRpn2:K48-diubiquitin | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | | 著者 | Lu, X, Walters, K.J. | | 登録日 | 2019-11-13 | | 公開日 | 2020-03-11 | | 最終更新日 | 2020-05-20 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
Structure, 28, 2020
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6UYI
 | | hRpn13:hRpn2:K48-diubiquitin | | 分子名称: | 26S proteasome non-ATPase regulatory subunit 1, Proteasomal ubiquitin receptor ADRM1, Ubiquitin | | 著者 | Lu, X, Walters, K.J. | | 登録日 | 2019-11-13 | | 公開日 | 2020-03-11 | | 最終更新日 | 2022-03-16 | | 実験手法 | SOLUTION NMR | | 主引用文献 | An Extended Conformation for K48 Ubiquitin Chains Revealed by the hRpn2:Rpn13:K48-Diubiquitin Structure.
Structure, 28, 2020
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2N12
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2N0Z
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