7KXI

Structure of XL5-ligated hRpn13 Pru domain

Summary for 7KXI

• Entry DOI: 10.2210/pdb7kxi/pdb
• NMR Information: BMRB: 30824
• Descriptor: Proteasomal ubiquitin receptor ADRM1, 2-{[(2S)-2-cyano-3-{3-[(4-methylbenzene-1-carbonyl)amino]phenyl}propanoyl]amino}benzoic acid (2 entities in total)
• Functional Keywords: complex, protein binding
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 17467.79

Authors

Lu, X.,Walters, K.J. (deposition date: 2020-12-03, release date: 2021-12-15, Last modification date: 2021-12-29)

• Primary citation: Lu, X.,Sabbasani, V.R.,Osei-Amponsa, V.,Evans, C.N.,King, J.C.,Tarasov, S.G.,Dyba, M.,Das, S.,Chan, K.C.,Schwieters, C.D.,Choudhari, S.,Fromont, C.,Zhao, Y.,Tran, B.,Chen, X.,Matsuo, H.,Andresson, T.,Chari, R.,Swenson, R.E.,Tarasova, N.I.,Walters, K.J.; Structure-guided bifunctional molecules hit a DEUBAD-lacking hRpn13 species upregulated in multiple myeloma.; Nat Commun, 12:7318-7318, 2021; PubMed: 34916494; DOI: 10.1038/s41467-021-27570-4

Experimental method

SOLUTION NMR