5U6Z
 
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6CXS
 | | Crystal Structure of Clostridium perfringens beta-glucuronidase bound with a novel, potent inhibitor 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine | | 分子名称: | 4-(8-(piperazin-1-yl)-1,2,3,4-tetrahydro-[1,2,3]triazino[4',5':4,5]thieno[2,3-c]isoquinolin-5-yl)morpholine, Beta-glucuronidase, Maltose/maltodextrin-binding periplasmic protein | | 著者 | Wallace, B.D, Redinbo, M.R. | | 登録日 | 2018-04-04 | | 公開日 | 2019-04-17 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Targeted inhibition of gut bacterial beta-glucuronidase activity enhances anticancer drug efficacy.
Proc.Natl.Acad.Sci.USA, 2020
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4JKL
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4J5W
 | | Crystal Structure of the apo-PXR/RXRalpha LBD Heterotetramer Complex | | 分子名称: | MAGNESIUM ION, Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, ... | | 著者 | Wallace, B.D, Betts, L, Redinbo, M.R. | | 登録日 | 2013-02-10 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha.
J.Mol.Biol., 425, 2013
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4JKK
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4JKM
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4J5X
 | | Crystal Structure of the SR12813-bound PXR/RXRalpha LBD Heterotetramer Complex | | 分子名称: | Nuclear receptor subfamily 1 group I member 2, Nuclear receptor coactivator 1, Retinoic acid receptor RXR-alpha, ... | | 著者 | Wallace, B.D, Betts, L, Redinbo, M.R. | | 登録日 | 2013-02-10 | | 公開日 | 2013-08-21 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural and Functional Analysis of the Human Nuclear Xenobiotic Receptor PXR in Complex with RXRalpha.
J.Mol.Biol., 425, 2013
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4EM3
 | | Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor MeVS-CoA | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Wallace, B.D, Edwards, J.S, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-11 | | 公開日 | 2012-10-17 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.977 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EQS
 | | Crystal structure of the Y419F mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, COENZYME A, Coenzyme A disulfide reductase, ... | | 著者 | Wallace, B.D, Edwards, J.S, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EM4
 | | Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor Pethyl-VS-CoA | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Wallace, B.D, Edwards, J.S, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-11 | | 公開日 | 2012-10-17 | | 最終更新日 | 2017-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.821 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EQR
 | | Crystal structure of the Y361F mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, COENZYME A, Coenzyme A disulfide reductase, ... | | 著者 | Wallace, B.D, Edwards, J.S, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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3LPF
 | | Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea | | 分子名称: | 1-[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea, Beta-glucuronidase | | 著者 | Wallace, B.D, Redinbo, M.R. | | 登録日 | 2010-02-05 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science, 330, 2010
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3LPG
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3K46
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3K4D
 | | Crystal structure of E. coli beta-glucuronidase with the glucaro-d-lactam inhibitor bound | | 分子名称: | (2S,3R,4S,5R)-3,4,5-trihydroxy-6-oxopiperidine-2-carboxylic acid, Beta-glucuronidase | | 著者 | Wallace, B.D, Redinbo, M.R. | | 登録日 | 2009-10-05 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | | 主引用文献 | Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science, 330, 2010
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3K4A
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3MBO
 | | Crystal Structure of the Glycosyltransferase BaBshA bound with UDP and L-malate | | 分子名称: | D-MALATE, GLYCEROL, Glycosyltransferase, ... | | 著者 | Wallace, B.D, Claiborne, A, Redinbo, M.R. | | 登録日 | 2010-03-25 | | 公開日 | 2010-09-29 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.307 Å) | | 主引用文献 | Characterization of the N-Acetyl-alpha-d-glucosaminyl
l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis
in Bacillus anthracis
Biochemistry, 49, 2010
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5KIV
 | | Crystal structure of SauMacro (SAV0325) | | 分子名称: | 1,2-ETHANEDIOL, ETHANOL, Protein-ADP-ribose hydrolase, ... | | 著者 | Williams, R.S, Appel, C.D, Feld, G.K, Wallace, B.D. | | 登録日 | 2016-06-17 | | 公開日 | 2016-07-13 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structure of the sirtuin-linked macrodomain SAV0325 from Staphylococcus aureus.
Protein Sci., 25, 2016
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6WCD
 | | Crystal Structure of Xenopus laevis APE2 Catalytic Domain | | 分子名称: | 1,2-ETHANEDIOL, 1,4-BUTANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ... | | 著者 | Wojtaszek, J.L, Wallace, B.D, Williams, R.S. | | 登録日 | 2020-03-30 | | 公開日 | 2020-05-06 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | | 主引用文献 | Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease.
Mol.Cell, 78, 2020
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7N3Z
 | | Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, DNA-(apurinic or apyrimidinic site) endonuclease 2, ... | | 著者 | Wojtaszek, J.L, Wallace, B.D, Williams, R.S. | | 登録日 | 2021-06-02 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | | 主引用文献 | Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Cell Rep, 41, 2022
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7N3Y
 | | Crystal Structure of Saccharomyces cerevisiae Apn2 Catalytic Domain E59Q/D222N Mutant in Complex with DNA | | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, CITRIC ACID, ... | | 著者 | Wojtaszek, J.L, Krahn, J, Wallace, B.D, Williams, R.S. | | 登録日 | 2021-06-02 | | 公開日 | 2022-09-28 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.73 Å) | | 主引用文献 | Molecular basis for processing of topoisomerase 1-triggered DNA damage by Apn2/APE2.
Cell Rep, 41, 2022
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4JHZ
 | | Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[(1S,2S,5S)-2,5-dimethoxycyclohexyl]acetamide | | 分子名称: | 2-[4-(1,3-benzodioxol-5-ylmethyl)piperazin-1-yl]-N-[(1S,2S,5S)-2,5-dimethoxycyclohexyl]acetamide, Beta-glucuronidase | | 著者 | Roberts, A.B, Wallace, B.D, Redinbo, M.R. | | 登録日 | 2013-03-05 | | 公開日 | 2013-08-28 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (2.831 Å) | | 主引用文献 | Molecular Insights into Microbial beta-Glucuronidase Inhibition to Abrogate CPT-11 Toxicity.
Mol.Pharmacol., 84, 2013
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4EMW
 | | Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor EtVC-CoA | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Edwards, J.S, Wallace, B.D, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-12 | | 公開日 | 2012-10-17 | | 最終更新日 | 2019-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EQX
 | | Crystal Structure of the C43S Mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Edwards, J.S, Wallace, B.D, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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4EQW
 | | Crystal Structure of the Y361F, Y419F Mutant of Staphylococcus aureus CoADR | | 分子名称: | CHLORIDE ION, COENZYME A, Coenzyme A disulfide reductase, ... | | 著者 | Edwards, J.S, Wallace, B.D, Wallen, J.R, Claiborne, A, Redinbo, M.R. | | 登録日 | 2012-04-19 | | 公開日 | 2012-10-17 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights.
Biochemistry, 51, 2012
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