4EM3

Crystal Structure of Staphylococcus aureus bound with the covalent inhibitor MeVS-CoA

Summary for 4EM3

Entry DOI	10.2210/pdb4em3/pdb
Related	1YQZ 4EM4 4EMW 4EQR 4EQS 4EQW 4EQX
Descriptor	Coenzyme A disulfide reductase, FLAVIN-ADENINE DINUCLEOTIDE, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Staphylococcus aureus subsp. aureus
Total number of polymer chains	2
Total formula weight	102072.20
Authors	Wallace, B.D.,Edwards, J.S.,Claiborne, A.,Redinbo, M.R. (deposition date: 2012-04-11, release date: 2012-10-17, Last modification date: 2017-11-15)
Primary citation	Wallace, B.D.,Edwards, J.S.,Wallen, J.R.,Moolman, W.J.,van der Westhuyzen, R.,Strauss, E.,Redinbo, M.R.,Claiborne, A. Turnover-Dependent Covalent Inactivation of Staphylococcus aureus Coenzyme A-Disulfide Reductase by Coenzyme A-Mimetics: Mechanistic and Structural Insights. Biochemistry, 51:7699-7711, 2012 Cited by PubMed: 22954034 DOI: 10.1021/bi301026c PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.977 Å)

Structure validation