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PDB: 1442 件
7VIB
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BU of 7vib by Molmil
Crystal structure of human ACE2 and GX/P2V RBD
分子名称: Angiotensin-converting enzyme 2, Spike glycoprotein, ZINC ION
著者Guo, Y, Cao, W, Jia, N, Wang, W, Yuan, S, Wang, Y.
登録日2021-09-26
公開日2022-10-05
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Crystal structure of human ACE2 and GX/P2V RBD
To Be Published
5H1L
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BU of 5h1l by Molmil
Crystal structure of WD40 repeat domains of Gemin5 in complex with 7-nt U4 snRNA fragment
分子名称: GLYCEROL, Gem-associated protein 5, U4 snRNA (5'-R(*AP*UP*UP*UP*UP*UP*G)-3')
著者Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M.
登録日2016-10-10
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
4N9C
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BU of 4n9c by Molmil
Fragment-based Design of 3-Aminopyridine-derived Amides as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT)
分子名称: 5-nitro-1H-benzimidazole, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION
著者Dragovich, P.S, Zhao, G, Baumeister, T, Bravo, B, Giannetti, A.M, Ho, Y, Hua, R, Li, G, Liang, X, O'Brien, T, Skelton, N.J, Wang, C, Zhao, Q, Oh, A, Wang, W, Wang, Y, Xiao, Y, Yuen, P, Zak, M, Zheng, X.
登録日2013-10-20
公開日2014-02-19
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.751 Å)
主引用文献Fragment-based design of 3-aminopyridine-derived amides as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT).
Bioorg.Med.Chem.Lett., 24, 2014
5H1M
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BU of 5h1m by Molmil
Crystal structure of WD40 repeat domains of Gemin5 in complex with M7G
分子名称: 7N-METHYL-8-HYDROGUANOSINE-5'-DIPHOSPHATE, Gem-associated protein 5
著者Jin, W, Wang, Y, Liu, C.P, Yang, N, Jin, M, Cong, Y, Wang, M, Xu, R.M.
登録日2016-10-10
公開日2016-11-23
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.492 Å)
主引用文献Structural basis for snRNA recognition by the double-WD40 repeat domain of Gemin5
Genes Dev., 30, 2016
1OP1
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BU of 1op1 by Molmil
Solution NMR structure of domain 1 of receptor associated protein
分子名称: Alpha-2-macroglobulin receptor-associated protein precursor
著者Wu, Y, Migliorini, M, Yu, P, Strickland, D.K, Wang, Y.-X.
登録日2003-03-04
公開日2003-08-26
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献1H, 13C and 15N resonance assignments of domain 1 of receptor associated protein.
J.Biomol.Nmr, 26, 2003
5GNF
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BU of 5gnf by Molmil
Crystal structure of anti-CRISPR protein AcrF3
分子名称: CALCIUM ION, Uncharacterized protein AcrF3
著者Wang, J, Wang, Y.
登録日2016-07-20
公開日2016-09-21
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses
Cell Res., 26, 2016
1K1T
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BU of 1k1t by Molmil
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
分子名称: N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN, SULFATE ION
著者Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, Harrison, R.W, Weber, I.T.
登録日2001-09-25
公開日2002-07-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.2 Å)
主引用文献Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
1K2C
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BU of 1k2c by Molmil
Combining Mutations in HIV-1 Protease to Understand Mechanisms of Resistance
分子名称: N-[(2R)-2-({N~5~-[amino(iminio)methyl]-L-ornithyl-L-valyl}amino)-4-methylpentyl]-L-phenylalanyl-L-alpha-glutamyl-L-alanyl-L-norleucinamide, PROTEASE RETROPEPSIN
著者Mahalingam, B, Boross, P, Wang, Y.-F, Louis, J.M, Fischer, C, Tozser, J, W Harrison, R, Weber, I.T.
登録日2001-09-26
公開日2002-07-10
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Combining mutations in HIV-1 protease to understand mechanisms of resistance.
Proteins, 48, 2002
8TG1
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BU of 8tg1 by Molmil
Caldicellulosiruptor saccharolyticus periplasmic urea-binding protein
分子名称: BROMIDE ION, Extracellular ligand-binding receptor, UREA
著者Allert, M.J, Kumar, S, Wang, Y, Beese, L.S, Hellinga, H.W.
登録日2023-07-12
公開日2024-06-19
実験手法X-RAY DIFFRACTION (2.097 Å)
主引用文献Structure-based functional analysis reveals multiple roles and widespread use of urea-binding proteins in nitrogen metabolism
To Be Published
8YZ7
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BU of 8yz7 by Molmil
Crystal structure of DdrI, a CRP family protein from Deinococcus radiodurans
分子名称: POTASSIUM ION, Transcriptional regulator, FNR/CRP family
著者Zhao, Y, Wang, Y.
登録日2024-04-06
公開日2024-07-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献cAMP-independent DNA binding of the CRP family protein DdrI from Deinococcus radiodurans.
Mbio, 2024
6NNG
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BU of 6nng by Molmil
Tubulin-RB3_SLD-TTL in complex with compound DJ95
分子名称: 2-(1H-indol-6-yl)-4-(3,4,5-trimethoxyphenyl)-1H-imidazo[4,5-c]pyridine, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Kumar, G, Wang, Y, Li, W, White, S.W.
登録日2019-01-15
公開日2019-07-10
最終更新日2019-12-04
実験手法X-RAY DIFFRACTION (2.397 Å)
主引用文献Colchicine Binding Site Agent DJ95 Overcomes Drug Resistance and Exhibits Antitumor Efficacy.
Mol.Pharmacol., 96, 2019
8GUP
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BU of 8gup by Molmil
Crystal structure of EsaG from Staphylococcus aureus
分子名称: CITRIC ACID, Type VII secretion system protein EsaG
著者Zhang, Z.M, Wang, Y.J.
登録日2022-09-13
公開日2022-11-09
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.298725 Å)
主引用文献A toxin-deformation dependent inhibition mechanism in the T7SS toxin-antitoxin system of Gram-positive bacteria.
Nat Commun, 13, 2022
8JDI
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BU of 8jdi by Molmil
Crystal structure of Cas7-AcrIF25 complex
分子名称: AcrIF25, CRISPR-associated protein Csy3
著者Yang, J, Wang, J, Wang, Y.
登録日2023-05-14
公開日2024-05-29
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (3.372 Å)
主引用文献An anti-CRISPR that pulls apart a CRISPR-Cas complex.
Nature, 2024
8JDH
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BU of 8jdh by Molmil
Crystal structure of anti-CRISPR AcrIF25
分子名称: AcrIF25
著者Yang, J, Wang, J, Wang, Y.
登録日2023-05-14
公開日2024-05-29
最終更新日2024-07-24
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献An anti-CRISPR that pulls apart a CRISPR-Cas complex.
Nature, 2024
7V3L
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BU of 7v3l by Molmil
MERS S ectodomain trimer in complex with neutralizing antibody 6516
分子名称: Spike glycoprotein, antibody H, antibody L
著者Wang, X, Zhao, J, Wang, Z, Wang, Y, Zeng, J.
登録日2021-08-10
公開日2022-08-17
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献MERS S ectodomain trimer in complex with neutralizing antibody 6516
to be published
1MRH
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BU of 1mrh by Molmil
STUDIES ON CRYSTAL STRUCTURES ACTIVE CENTER GEOMETRY AND DEPURINE MECHANISM OF TWO RIBOSOME-INACTIVATING PROTEINS
分子名称: (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, ALPHA-MOMORCHARIN
著者Huang, Q, Liu, S, Tang, Y, Jin, S, Wang, Y.
登録日1994-07-01
公開日1995-02-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Studies on crystal structures, active-centre geometry and depurinating mechanism of two ribosome-inactivating proteins.
Biochem.J., 309, 1995
1MRK
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BU of 1mrk by Molmil
STUDIES ON CRYSTAL STRUCTURES ACTIVE CENTER GEOMETRY AND DEPURINE MECHANISM OF TWO RIBOSOME-INACTIVATING PROTEINS
分子名称: (1S)-1-(7-amino-1H-pyrazolo[4,3-d]pyrimidin-3-yl)-1,4-anhydro-D-ribitol, ALPHA-TRICHOSANTHIN
著者Huang, Q, Liu, S, Tang, Y, Jin, S, Wang, Y.
登録日1994-07-01
公開日1995-02-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Studies on crystal structures, active-centre geometry and depurinating mechanism of two ribosome-inactivating proteins.
Biochem.J., 309, 1995
5XAF
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BU of 5xaf by Molmil
Crystal structure of tubulin-stathmin-TTL-Compound Z1 complex
分子名称: (3S,4R)-4-(3-hydroxy-4-methoxyphenyl)-3-methyl-1-(3,4,5-trimethoxyphenyl)azetidin-2-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ...
著者Zhang, H, Luo, C, Wang, Y.
登録日2017-03-12
公開日2017-12-20
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.551 Å)
主引用文献Design, synthesis, biological evaluation and cocrystal structures with tubulin of chiral beta-lactam bridged combretastatin A-4 analogues as potent antitumor agents
Eur J Med Chem, 144, 2017
8HNS
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BU of 8hns by Molmil
Crystal structure of an anti-CRISPR protein AcrIIC4 in apo form
分子名称: GLYCEROL, anti-CRISPR protein AcrIIC4
著者Sun, W, Cheng, Z, Yang, J, Wang, Y.
登録日2022-12-08
公開日2023-07-19
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (2.54 Å)
主引用文献AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
Proc.Natl.Acad.Sci.USA, 120, 2023
8HNT
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BU of 8hnt by Molmil
Crystal structure of anti-CRISPR protein AcrIIC4 bound to HpaCas9-sgRNA surveillance complex
分子名称: CRISPR-associated endonuclease Cas9, anti-CRISPR protein AcrIIC4, sgRNA
著者Sun, W, Cheng, Z, Wang, Y.
登録日2022-12-08
公開日2023-07-19
最終更新日2024-05-29
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献AcrIIC4 inhibits type II-C Cas9 by preventing R-loop formation.
Proc.Natl.Acad.Sci.USA, 120, 2023
5XQ2
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BU of 5xq2 by Molmil
Crystal structure of T. thermophilus Argonaute protein complexed with a bulge 5A6 on the guide strand
分子名称: DNA (5'-D(*AP*CP*AP*AP*CP*CP*TP*AP*CP*TP*AP*CP*CP*TP*CP*G)-3'), DNA (5'-D(*AP*GP*T)-3'), DNA (5'-D(P*TP*GP*AP*AP*GP*AP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*T)-3'), ...
著者Sheng, G, Gogakos, T, Wang, J, Zhao, H, Serganov, A, Juranek, S, Tuschl, T, Patel, D, Wang, Y.
登録日2017-06-06
公開日2017-10-04
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.33 Å)
主引用文献Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Nucleic Acids Res., 45, 2017
1FHS
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BU of 1fhs by Molmil
THE THREE-DIMENSIONAL SOLUTION STRUCTURE OF THE SRC HOMOLOGY DOMAIN-2 OF THE GROWTH FACTOR RECEPTOR BOUND PROTEIN-2, NMR, 18 STRUCTURES
分子名称: GROWTH FACTOR RECEPTOR BOUND PROTEIN-2
著者Senior, M.M, Frederick, A.F, Black, S, Perkins, L.M, Wilson, O, Snow, M.E, Wang, Y.-S.
登録日1997-06-12
公開日1998-06-17
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The three-dimensional solution structure of the Src homology domain-2 of the growth factor receptor-bound protein-2.
J.Biomol.NMR, 11, 1998
1MRI
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BU of 1mri by Molmil
STUDIES ON CRYSTAL STRUCTURES ACTIVE CENTER GEOMETRY AND DEPURINE MECHANISM OF TWO RIBOSOME-INACTIVATING PROTEINS
分子名称: ALPHA-MOMORCHARIN
著者Huang, Q, Liu, S, Tang, Y, Jin, S, Wang, Y.
登録日1994-07-01
公開日1995-02-07
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Studies on crystal structures, active-centre geometry and depurinating mechanism of two ribosome-inactivating proteins.
Biochem.J., 309, 1995
3K3N
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BU of 3k3n by Molmil
Crystal structure of the catalytic core domain of human PHF8
分子名称: FE (II) ION, PHD finger protein 8
著者Yu, L, Wang, Y, Huang, S, Wang, J, Deng, Z, Wu, W, Gong, W, Chen, Z.
登録日2009-10-03
公開日2010-01-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural insights into a novel histone demethylase PHF8
Cell Res., 20, 2010
3K3O
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BU of 3k3o by Molmil
Crystal structure of the catalytic core domain of human PHF8 complexed with alpha-ketoglutarate
分子名称: 2-OXOGLUTARIC ACID, FE (II) ION, PHD finger protein 8
著者Yu, L, Wang, Y, Huang, S, Wang, J, Deng, Z, Wu, W, Gong, W, Chen, Z.
登録日2009-10-03
公開日2010-01-19
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural insights into a novel histone demethylase PHF8
Cell Res., 20, 2010

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