1LKX
 
 | | MOTOR DOMAIN OF MYOE, A CLASS-I MYOSIN | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, MYOSIN IE HEAVY CHAIN, ... | | Authors: | Kollmar, M, Durrwang, U, Kliche, W, Manstein, D.J, Kull, F.J. | | Deposit date: | 2002-04-26 | | Release date: | 2002-06-26 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the motor domain of a class-I myosin.
EMBO J., 21, 2002
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3QZU
 | | Crystal structure of Bacillus subtilis Lipase A 7-fold mutant; the outcome of directed evolution towards thermostability | | Descriptor: | CHLORIDE ION, GLYCEROL, Lipase estA, ... | | Authors: | Pijning, T, Augustyniak, W, Reetz, M.T, Dijkstra, B.W. | | Deposit date: | 2011-03-07 | | Release date: | 2012-02-08 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Biophysical characterization of mutants of Bacillus subtilis lipase evolved for thermostability: Factors contributing to increased activity retention.
Protein Sci., 21, 2012
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5IJF
 | | Crystal structure of Human Serum Albumin in the presence of 0.5 mM zinc at pH 9.0 | | Descriptor: | Serum albumin, UNKNOWN LIGAND, ZINC ION | | Authors: | Handing, K.B, Shabalin, I.G, Cooper, D.R, Grabowski, M, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | | Deposit date: | 2016-03-02 | | Release date: | 2016-03-16 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Circulatory zinc transport is controlled by distinct interdomain sites on mammalian albumins.
Chem Sci, 7, 2016
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3ROE
 | | Crystal Structure of Mouse Apolipoprotein A-I Binding Protein in Complex with Thymidine | | Descriptor: | Apolipoprotein A-I-binding protein, THYMIDINE | | Authors: | Shumilin, I.A, Jha, K.N, Cymborowski, M, Herr, J.C, Minor, W. | | Deposit date: | 2011-04-25 | | Release date: | 2012-07-18 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Identification of unknown protein function using metabolite cocktail screening.
Structure, 20, 2012
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2RLC
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1GL2
 | | Crystal structure of an endosomal SNARE core complex | | Descriptor: | ENDOBREVIN, SYNTAXIN 7, SYNTAXIN 8, ... | | Authors: | Antonin, W, Becker, S, Jahn, R, Schneider, T.R. | | Deposit date: | 2001-08-22 | | Release date: | 2002-01-15 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal Structure of the Endosomal Snare Complex Reveals Common Structural Principles of All Snares.
Nat.Struct.Biol., 9, 2001
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3RQX
 | | Crystal Structure of ADP/ATP-dependent NAD(P)H-hydrate dehydratase from Bacillus subtilis in complex with P1,P4-Di(adenosine-5') tetraphosphate | | Descriptor: | ADP/ATP-DEPENDENT NAD(P)H-HYDRATE DEHYDRATASE, BIS(ADENOSINE)-5'-TETRAPHOSPHATE, CHLORIDE ION, ... | | Authors: | Shumilin, I.A, Cymborowski, M, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2011-04-28 | | Release date: | 2011-07-27 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Identification of unknown protein function using metabolite cocktail screening.
Structure, 20, 2012
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2RJQ
 | | Crystal structure of ADAMTS5 with inhibitor bound | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(N-HYDROXYAMINO)-2R-ISOBUTYL-2S-(2-THIENYLTHIOMETHYL)SUCCINYL-L-PHENYLALANINE-N-METHYLAMIDE, ADAMTS-5, ... | | Authors: | Mosyak, L, Stahl, M, Somers, W. | | Deposit date: | 2007-10-15 | | Release date: | 2007-12-11 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal structures of the two major aggrecan degrading enzymes, ADAMTS4 and ADAMTS5.
Protein Sci., 17, 2008
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6D08
 | | Crystal structure of an engineered bump-hole complex of mutant human chromobox homolog 1 (CBX1) with H3K9bn peptide | | Descriptor: | Chromobox protein homolog 1, GLYCEROL, Histone H3.1, ... | | Authors: | Arora, S, Horne, W.S, Islam, K. | | Deposit date: | 2018-04-10 | | Release date: | 2019-04-10 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Engineering Methyllysine Writers and Readers for Allele-Specific Regulation of Protein-Protein Interactions.
J.Am.Chem.Soc., 141, 2019
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2RK4
 | | Structure of M26I DJ-1 | | Descriptor: | Protein DJ-1 | | Authors: | Lakshminarasimhan, M, Maldonado, M.T, Zhou, W, Fink, A.L, Wilson, M.A. | | Deposit date: | 2007-10-16 | | Release date: | 2008-01-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.15 Å) | | Cite: | Structural Impact of Three Parkinsonism-Associated Missense Mutations on Human DJ-1.
Biochemistry, 47, 2008
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1L3X
 | | Solution Structure of Novel Disintegrin Salmosin | | Descriptor: | platelet aggregation inhibitor disintegrin | | Authors: | Shin, J, Lee, W. | | Deposit date: | 2002-03-01 | | Release date: | 2003-12-23 | | Last modified: | 2012-11-21 | | Method: | SOLUTION NMR | | Cite: | Solution structure of a novel disintegrin, salmosin, from Agkistrondon halys venom
Biochemistry, 42, 2003
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1LPL
 | | Structural Genomics of Caenorhabditis elegans: CAP-Gly domain of F53F4.3 | | Descriptor: | Hypothetical 25.4 kDa protein F53F4.3 in chromosome V | | Authors: | Li, S, Finley, J, Liu, Z.-J, Qiu, S.H, Luan, C.H, Carson, M, Tsao, J, Johnson, D, Lin, G, Zhao, J, Thomas, W, Nagy, L.A, Sha, B, DeLucas, L.J, Wang, B.-C, Luo, M, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2002-05-08 | | Release date: | 2002-05-22 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.77 Å) | | Cite: | Crystal Structure of the
Cytoskeleton-associated Protein
Glycine-rich (CAP-Gly) Domain
J.Biol.Chem., 277, 2002
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6CTA
 | | Structure of the human cGAS-DNA complex with ATP | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Cyclic GMP-AMP synthase, DNA (5'-D(*AP*AP*AP*TP*TP*GP*CP*CP*GP*AP*AP*GP*AP*CP*GP*A)-3'), ... | | Authors: | Zhou, W, Whiteley, A.T, de Oliveira Mann, C.C, Morehouse, B.R, Mekalanos, J.J, Kranzusch, P.J. | | Deposit date: | 2018-03-22 | | Release date: | 2018-07-18 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.779 Å) | | Cite: | Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance.
Cell, 174, 2018
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5I50
 | | Structure of OmoMYC bound to double-stranded DNA | | Descriptor: | DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3'), Myc proto-oncogene protein | | Authors: | Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. | | Deposit date: | 2016-02-13 | | Release date: | 2016-10-26 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.701 Å) | | Cite: | OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.
Oncogene, 36, 2017
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7CRQ
 | | NSD3 bearing E1181K/T1232A dual mutation in complex with 187-bp NCP (2:1 binding mode) | | Descriptor: | DNA (168-MER), Histone H2A, Histone H2B, ... | | Authors: | Li, W, Tian, W, Yuan, G, Deng, P, Gozani, O, Patel, D, Wang, Z. | | Deposit date: | 2020-08-14 | | Release date: | 2020-10-21 | | Last modified: | 2021-03-03 | | Method: | ELECTRON MICROSCOPY (3.15 Å) | | Cite: | Molecular basis of nucleosomal H3K36 methylation by NSD methyltransferases.
Nature, 590, 2021
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3PEJ
 | | Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of Macbecin | | Descriptor: | Endoplasmin homolog, MACBECIN, SULFATE ION | | Authors: | Wernimont, A.K, Tempel, W, Hutchinson, A, Weadge, J, MacKenzie, F, Senisterra, G, Vedadi, M, Cossar, D, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Hui, R, Pizzaro, J.C, Hills, T, Structural Genomics Consortium (SGC) | | Deposit date: | 2010-10-26 | | Release date: | 2010-11-17 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Crystal Structure of the N-terminal domain of an HSP90 from Plasmodium Falciparum, PFL1070c in the presence of Macbecin
To be Published
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3M94
 | | Complex crystal structure of Ascaris suum eIF4E-3 with m2,2,7G cap | | Descriptor: | ACETYL GROUP, Eukaryotic translation initiation factor 4E-binding protein 1, N,N,7-trimethylguanosine 5'-(trihydrogen diphosphate), ... | | Authors: | Liu, W, Berkeley Structural Genomics Center (BSGC) | | Deposit date: | 2010-03-19 | | Release date: | 2011-07-20 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Structural basis for nematode eIF4E binding an m2,2,7G-Cap and its implications for translation initiation.
Nucleic Acids Res., 39, 2011
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2RB3
 | | Crystal Structure of Human Saposin D | | Descriptor: | GLYCEROL, Proactivator polypeptide, SULFATE ION | | Authors: | Maier, T, Rossman, M, Saenger, W. | | Deposit date: | 2007-09-18 | | Release date: | 2008-04-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal structures of human saposins C and d: implications for lipid recognition and membrane interactions.
Structure, 16, 2008
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1L7O
 | | CRYSTAL STRUCTURE OF PHOSPHOSERINE PHOSPHATASE IN APO FORM | | Descriptor: | ACETIC ACID, PHOSPHOSERINE PHOSPHATASE, ZINC ION | | Authors: | Wang, W, Cho, H.S, Kim, R, Jancarik, J, Yokota, H, Nguyen, H.H, Grigoriev, I.V, Wemmer, D.E, Kim, S.H, Berkeley Structural Genomics Center (BSGC) | | Deposit date: | 2002-03-16 | | Release date: | 2002-06-19 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural characterization of the reaction pathway in phosphoserine phosphatase: crystallographic "snapshots" of intermediate states.
J.Mol.Biol., 319, 2002
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2R52
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1L8A
 | | E. COLI PYRUVATE DEHYDROGENASE | | Descriptor: | MAGNESIUM ION, Pyruvate dehydrogenase E1 component, THIAMINE DIPHOSPHATE | | Authors: | Furey, W, Arjunan, P. | | Deposit date: | 2002-03-19 | | Release date: | 2002-07-24 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of the pyruvate dehydrogenase multienzyme complex E1 component from Escherichia coli at 1.85 A resolution.
Biochemistry, 41, 2002
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1L9L
 | | GRANULYSIN FROM HUMAN CYTOLYTIC T LYMPHOCYTES | | Descriptor: | 3[N-MORPHOLINO]PROPANE SULFONIC ACID, ETHANOL, Granulysin, ... | | Authors: | Anderson, D.H, Sawaya, M.R, Cascio, D, Ernst, W, Krensky, A, Modlin, R, Eisenberg, D. | | Deposit date: | 2002-03-25 | | Release date: | 2002-11-06 | | Last modified: | 2017-09-13 | | Method: | X-RAY DIFFRACTION (0.92 Å) | | Cite: | Granulysin Crystal Structure and a Structure-Derived Lytic Mechanism
J.Mol.Biol., 325, 2002
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2R9G
 | | Crystal structure of the C-terminal fragment of AAA ATPase from Enterococcus faecium | | Descriptor: | AAA ATPase, central region, ACETATE ION, ... | | Authors: | Ramagopal, U.A, Patskovsky, Y, Bonanno, J.B, Shi, W, Toro, R, Meyer, A.J, Rutter, M, Wu, B, Groshong, C, Gheyi, T, Sauder, J.M, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2007-09-12 | | Release date: | 2007-10-02 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.09 Å) | | Cite: | Crystal Structure of the C-Terminal Domain of AAA ATPase from Enterococcus faecium.
To be Published
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6CCU
 | | Complex between a GID4 fragment and a short peptide | | Descriptor: | Glucose-induced degradation protein 4 homolog, Short peptide, UNKNOWN ATOM OR ION | | Authors: | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2018-02-07 | | Release date: | 2018-03-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
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6CD9
 | | GID4 in complex with a peptide | | Descriptor: | Glucose-induced degradation protein 4 homolog, Tetrapeptide PSRW, UNKNOWN ATOM OR ION | | Authors: | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | Deposit date: | 2018-02-08 | | Release date: | 2018-03-07 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Molecular basis of GID4-mediated recognition of degrons for the Pro/N-end rule pathway.
Nat. Chem. Biol., 14, 2018
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