7WL4
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![BU of 7wl4 by Molmil](/molmil-images/mine/7wl4) | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor SLP-50 | 分子名称: | Bromodomain-containing protein 4, ~{N}-[2-ethyl-6-(4-methylpiperazin-1-yl)-3-oxidanylidene-2,7-diazatricyclo[6.3.1.0^{4,12}]dodeca-1(12),4,6,8,10-pentaen-9-yl]-2,4-bis(fluoranyl)benzenesulfonamide | 著者 | Zhang, C, Wang, C, Li, W, Zhang, Y, Xu, Y, Sun, L. | 登録日 | 2022-01-12 | 公開日 | 2022-08-10 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.82 Å) | 主引用文献 | Design, synthesis, and anticancer evaluation of ammosamide B with pyrroloquinoline derivatives as novel BRD4 inhibitors. Bioorg.Chem., 127, 2022
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7W6V
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![BU of 7w6v by Molmil](/molmil-images/mine/7w6v) | Crystal structure of a dicobalt-substituted small laccase at 2.47 angstrom | 分子名称: | COBALT (II) ION, Putative copper oxidase | 著者 | Yang, X, Wu, F, Wu, W, Chen, X, Fan, S, Yu, P, Mao, L. | 登録日 | 2021-12-02 | 公開日 | 2022-11-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | A versatile artificial metalloenzyme scaffold enabling direct bioelectrocatalysis in solution. Sci Adv, 8, 2022
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7WMV
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![BU of 7wmv by Molmil](/molmil-images/mine/7wmv) | Structure of human SGLT1-MAP17 complex bound with LX2761 | 分子名称: | N-[2-(dimethylamino)ethyl]-2-methyl-2-[4-[4-[[2-methyl-5-[(2S,3R,4R,5S,6R)-6-methylsulfanyl-3,4,5-tris(oxidanyl)oxan-2-yl]phenyl]methyl]phenyl]butanoylamino]propanamide, PDZK1-interacting protein 1, Sodium/glucose cotransporter 1 | 著者 | Chen, L, Niu, Y, Cui, W. | 登録日 | 2022-01-17 | 公開日 | 2022-11-16 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural mechanism of SGLT1 inhibitors. Nat Commun, 13, 2022
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6NRE
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7W1I
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![BU of 7w1i by Molmil](/molmil-images/mine/7w1i) | Crystal structure of carboxylesterase mutant from Thermobifida fusca with C8X and C9C | 分子名称: | 4-(2-hydroxyethyloxycarbonyl)benzoic acid, Carboxylesterase, bis(2-hydroxyethyl) benzene-1,4-dicarboxylate | 著者 | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | 登録日 | 2021-11-19 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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7W1K
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![BU of 7w1k by Molmil](/molmil-images/mine/7w1k) | Crystal structure of carboxylesterase from Thermobifida fusca | 分子名称: | Carboxylesterase | 著者 | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | 登録日 | 2021-11-19 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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7WN7
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![BU of 7wn7 by Molmil](/molmil-images/mine/7wn7) | Crystal structure of HearNPV P26 | 分子名称: | CHLORIDE ION, SULFATE ION, p26 | 著者 | Kuang, W, Hu, Z, Gong, P. | 登録日 | 2022-01-17 | 公開日 | 2022-11-23 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity. Nat Commun, 13, 2022
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7QVZ
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![BU of 7qvz by Molmil](/molmil-images/mine/7qvz) | ARUK3001043_Notum | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ... | 著者 | Zhao, Y, Hillier, J, Willis, N.J, Mahy, W, Fish, P, Jones, E.Y. | 登録日 | 2022-01-24 | 公開日 | 2022-05-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Structure Activity Analysis of Notum Fragment Screen Hits with Development To Be Published
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7W1Q
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1WVF
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![BU of 1wvf by Molmil](/molmil-images/mine/1wvf) | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon its Binding to the Cytochrome Subunit | 分子名称: | 4-cresol dehydrogenase [hydroxylating] flavoprotein subunit, ACETIC ACID, CHLORIDE ION, ... | 著者 | Cunane, L.M, Chen, Z.-W, McIntire, W.S, Mathews, F.S. | 登録日 | 2004-12-15 | 公開日 | 2005-03-08 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | p-Cresol Methylhydroxylase: Alteration of the Structure of the Flavoprotein Subunit upon Its Binding to the Cytochrome Subunit Biochemistry, 44, 2005
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7W1J
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![BU of 7w1j by Molmil](/molmil-images/mine/7w1j) | Crystal structure of carboxylesterase from Thermobifida fusca with J1K | 分子名称: | 4-(2-hydroxyethylcarbamoyl)benzoic acid, Carboxylesterase | 著者 | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | 登録日 | 2021-11-19 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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7W1L
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![BU of 7w1l by Molmil](/molmil-images/mine/7w1l) | Crystal structure of carboxylesterase mutant from Thermobifida fusca with C8X | 分子名称: | Carboxylesterase, bis(2-hydroxyethyl) benzene-1,4-dicarboxylate | 著者 | Han, X, Gerlis, H, Li, Z, Gao, J, Wei, R, Liu, W. | 登録日 | 2021-11-19 | 公開日 | 2022-11-23 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.44 Å) | 主引用文献 | Structural Insights into (Tere)phthalate-Ester Hydrolysis by a Carboxylesterase and Its Role in Promoting PET Depolymerization Acs Catalysis, 12, 2022
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7WEJ
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![BU of 7wej by Molmil](/molmil-images/mine/7wej) | Crystal structure of the mouse Wdr47 NTD. | 分子名称: | WD repeat-containing protein 47 | 著者 | Ren, J.Q, Li, D, Feng, W. | 登録日 | 2021-12-23 | 公開日 | 2022-11-30 | 実験手法 | X-RAY DIFFRACTION (3.09 Å) | 主引用文献 | Intertwined Wdr47-NTD dimer recognizes a basic-helical motif in Camsap proteins for proper central-pair microtubule formation. Cell Rep, 41, 2022
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7WEK
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7WGU
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![BU of 7wgu by Molmil](/molmil-images/mine/7wgu) | Crystal structure of metal-binding protein EfeO from Escherichia coli | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Iron uptake system protein EfeO, ... | 著者 | Nakatsuji, S, Takase, R, Mikami, B, Hashimoto, W. | 登録日 | 2021-12-29 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structures of EfeB and EfeO in a bacterial siderophore-independent iron transport system Biochem.Biophys.Res.Commun., 594, 2022
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7W9Q
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![BU of 7w9q by Molmil](/molmil-images/mine/7w9q) | Crystal structure of V30M-TTR in complex with naringenin derivative-14 | 分子名称: | (2~{R})-2-(3-chloranyl-4-oxidanyl-phenyl)-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, CALCIUM ION, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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1DQE
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![BU of 1dqe by Molmil](/molmil-images/mine/1dqe) | BOMBYX MORI PHEROMONE BINDING PROTEIN | 分子名称: | HEXADECA-10,12-DIEN-1-OL, PHEROMONE-BINDING PROTEIN | 著者 | Sandler, B.H, Nikonova, L, Leal, W.S, Clardy, J. | 登録日 | 2000-01-04 | 公開日 | 2001-01-10 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Sexual attraction in the silkworm moth: structure of the pheromone-binding-protein-bombykol complex. Chem.Biol., 7, 2000
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7W9R
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![BU of 7w9r by Molmil](/molmil-images/mine/7w9r) | Crystal structure of V30M-TTR in complex with naringenin derivative-18 | 分子名称: | (2~{R})-2-[3,5-bis(chloranyl)-4-oxidanyl-phenyl]-5,7-bis(oxidanyl)-2,3-dihydrochromen-4-one, Transthyretin | 著者 | Katayama, W, Shimane, A, Nabeshima, Y, Yokoyama, T, Mizuguchi, M. | 登録日 | 2021-12-10 | 公開日 | 2022-12-14 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.997 Å) | 主引用文献 | Chlorinated Naringenin Analogues as Potential Inhibitors of Transthyretin Amyloidogenesis. J.Med.Chem., 65, 2022
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6WZX
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![BU of 6wzx by Molmil](/molmil-images/mine/6wzx) | GID4 in complex with IGLWKS peptide | 分子名称: | Glucose-induced degradation protein 4 homolog, ILE-GLY-LEU-TRP-LYS peptide, UNKNOWN ATOM OR ION | 著者 | Dong, C, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | 登録日 | 2020-05-14 | 公開日 | 2020-06-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Recognition of nonproline N-terminal residues by the Pro/N-degron pathway. Proc.Natl.Acad.Sci.USA, 117, 2020
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1WUF
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![BU of 1wuf by Molmil](/molmil-images/mine/1wuf) | Crystal structure of protein GI:16801725, member of Enolase superfamily from Listeria innocua Clip11262 | 分子名称: | MAGNESIUM ION, hypothetical protein lin2664 | 著者 | Fedorov, A.A, Fedorov, E.V, Yew, W.S, Gerlt, J.A, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | 登録日 | 2004-12-07 | 公開日 | 2004-12-21 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Loss of quaternary structure is associated with rapid sequence divergence in the OSBS family Proc.Natl.Acad.Sci.USA, 111, 2014
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7WU7
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![BU of 7wu7 by Molmil](/molmil-images/mine/7wu7) | Prefoldin-tubulin-TRiC complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Prefoldin subunit 1, Prefoldin subunit 2, ... | 著者 | Gestaut, D, Zhao, Y, Park, J, Ma, B, Leitner, A, Collier, M, Pintilie, G, Roh, S.-H, Chiu, W, Frydman, J. | 登録日 | 2022-02-07 | 公開日 | 2022-12-21 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (3.85 Å) | 主引用文献 | Structural visualization of the tubulin folding pathway directed by human chaperonin TRiC/CCT. Cell, 185, 2022
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7WQR
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![BU of 7wqr by Molmil](/molmil-images/mine/7wqr) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 28 | 分子名称: | Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ~{N}-(3-chlorophenyl)-2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]benzamide | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | 登録日 | 2022-01-25 | 公開日 | 2023-01-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.124 Å) | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247, 2022
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7WQS
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![BU of 7wqs by Molmil](/molmil-images/mine/7wqs) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 25 | 分子名称: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(3-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | 登録日 | 2022-01-26 | 公開日 | 2023-01-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247, 2022
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7WQM
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![BU of 7wqm by Molmil](/molmil-images/mine/7wqm) | Crystal structure of Aldo-keto reductase 1C3 complexed with compound 24 | 分子名称: | 2-[(3,5-dimethyl-1,2-oxazol-4-yl)methoxy]-~{N}-(2-methoxyphenyl)benzamide, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Sun, H, Fang, P. | 登録日 | 2022-01-25 | 公開日 | 2023-01-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | 主引用文献 | Development of highly potent and specific AKR1C3 inhibitors to restore the chemosensitivity of drug-resistant breast cancer. Eur.J.Med.Chem., 247, 2022
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7WCC
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![BU of 7wcc by Molmil](/molmil-images/mine/7wcc) | Oxidase ChaP-D49L/Q91C mutant | 分子名称: | ChaP, FE (III) ION | 著者 | Sun, M.X, Zheng, W, Wang, Y.S, Zhu, J.P, Tan, R.X. | 登録日 | 2021-12-19 | 公開日 | 2023-05-24 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Oxidase ChaP-D49L/Q91C mutant To Be Published
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