8W9B
 
 | | CryoEM structure of human PI3K-alpha (P85/P110-H1047R) with QR-8557 binding at an allosteric site | | 分子名称: | 1-[(1S)-1-(5-fluoranyl-3-methyl-1-benzofuran-2-yl)-2-methyl-propyl]-3-(1-oxidanylidene-2,3-dihydroisoindol-5-yl)urea, Phosphatidylinositol 3-kinase regulatory subunit alpha, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Huang, X, Ren, X, Zhong, W. | | 登録日 | 2023-09-05 | | 公開日 | 2024-04-17 | | 最終更新日 | 2024-07-24 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Cryo-EM structures reveal two allosteric inhibition modes of PI3K alpha H1047R involving a re-shaping of the activation loop.
Structure, 32, 2024
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8WTF
 | | The Crystal Structure of IRAK4 from Biortus | | 分子名称: | 1,2-ETHANEDIOL, 1-{[(2S,3S,4S)-3-ethyl-4-fluoro-5-oxopyrrolidin-2-yl]methoxy}-7-methoxyisoquinoline-6-carboxamide, Interleukin-1 receptor-associated kinase 4, ... | | 著者 | Wang, F, Cheng, W, Lv, Z, Meng, Q, Xu, Y. | | 登録日 | 2023-10-18 | | 公開日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Crystal Structure of IRAK4 from Biortus
To Be Published
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8YM1
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8WR5
 | | The Crystal Structure of Mms2 from Biortus | | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, Ubiquitin-conjugating enzyme E2 variant 2 | | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. | | 登録日 | 2023-10-13 | | 公開日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | The Crystal Structure of Mms2 from Biortus.
To Be Published
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8YKW
 | | Cryo-EM structure of succinate receptor SUCR1 bound to succinic acid | | 分子名称: | Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E. | | 登録日 | 2024-03-05 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | ELECTRON MICROSCOPY (2.75 Å) | | 主引用文献 | Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 2024
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8WP0
 | | Structure of the Arabidopsis E529Q/E1174Q ABCB19 in the ATP bound state | | 分子名称: | ABC transporter B family member 19, ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION | | 著者 | Ying, W, Wei, H, Liu, X, Sun, L. | | 登録日 | 2023-10-08 | | 公開日 | 2024-03-13 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structure and function of the Arabidopsis ABC transporter ABCB19 in brassinosteroid export.
Science, 383, 2024
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8WFG
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8X15
 | | Structure of nucleosome-bound SRCAP-C in the apo state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | | 著者 | Yu, J, Wang, Q, Yu, Z, Li, W, Wang, L, Xu, Y. | | 登録日 | 2023-11-06 | | 公開日 | 2024-03-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Structural insights into histone exchange by human SRCAP complex.
Cell Discov, 10, 2024
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8WYI
 | | T cell receptor delta 2 gamma 9 with TCRD TM domain chimera of TRAC | | 分子名称: | Signal peptide,flag tag,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant,T cell receptor delta variable 2,T cell receptor delta constant,T cell receptor alpha chain constant, Signal peptide,flag tag,T cell receptor gamma variable 9,T cell receptor gamma constant 1,T cell receptor gamma variable 9,T cell receptor gamma constant 1, T-cell surface glycoprotein CD3 delta chain, ... | | 著者 | Xin, W, Huang, B, Chi, X, Liu, Y, Xu, M, Zhang, Y, Li, X, Su, Q, Zhou, Q. | | 登録日 | 2023-10-31 | | 公開日 | 2024-05-08 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structures of human gamma delta T cell receptor-CD3 complex.
Nature, 630, 2024
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8XI7
 | | The Crystal Structure of UCHL1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, SULFATE ION, Ubiquitin carboxyl-terminal hydrolase isozyme L1 | | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Shen, Z. | | 登録日 | 2023-12-19 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Crystal Structure of UCHL1 from Biortus.
To Be Published
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8WRA
 | | The Crystal Structure of CASP1 from Biortus | | 分子名称: | 1,2-ETHANEDIOL, Caspase-1 | | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Guo, S. | | 登録日 | 2023-10-13 | | 公開日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | The Crystal Structure of CASP1 from Biortus.
To Be Published
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8WGF
 | | The Crystal Structure of JNK3 from Biortus. | | 分子名称: | MAGNESIUM ION, Mitogen-activated protein kinase 10, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Wang, F, Cheng, W, Lv, Z, Ju, C, Wang, J. | | 登録日 | 2023-09-21 | | 公開日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The Crystal Structure of JNK3 from Biortus.
To Be Published
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1ZDT
 | | The Crystal Structure of Human Steroidogenic Factor-1 | | 分子名称: | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Nuclear receptor coactivator 2, Steroidogenic factor 1 | | 著者 | Wang, W, Zhang, C, Marimuthu, A, Krupka, H.I, Tabrizizad, M, Shelloe, R, Mehra, U, Eng, K, Nguyen, H, Settachatgul, C, Powell, B, Milburn, M.V, West, B.L. | | 登録日 | 2005-04-14 | | 公開日 | 2005-05-24 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | The crystal structures of human steroidogenic factor-1 and liver receptor homologue-1
Proc.Natl.Acad.Sci.USA, 102, 2005
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1ZBJ
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8X5M
 | | The Crystal Structure of JNK1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, 3-[4-(dimethylamino)butanoylamino]-~{N}-[3-methyl-4-[(4-pyridin-3-ylpyrimidin-2-yl)amino]phenyl]benzamide, GLYCEROL, ... | | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | | 登録日 | 2023-11-17 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The Crystal Structure of JNK1 from Biortus.
To Be Published
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9B3R
 | | The structure of human cardiac F-actin | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin, alpha cardiac muscle 1, ... | | 著者 | Doran, M.H, Sousa, D, Rynkiewicz, M.J, Lehman, W, Cammarato, A. | | 登録日 | 2024-03-20 | | 公開日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structure of human cardiac actin
To Be Published
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8XP5
 | | The Crystal Structure of p53/BCL-xL fusion complex from Biortus. | | 分子名称: | Bcl-2-like protein 1,Cellular tumor antigen p53, ZINC ION | | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Bao, C. | | 登録日 | 2024-01-03 | | 公開日 | 2024-03-06 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | The Crystal Structure of p53/BCL-xL fusion complex from Biortus.
To Be Published
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8X79
 | | MRE-269 bound Prostacyclin Receptor G protein complex | | 分子名称: | 2-[4-[(5,6-diphenylpyrazin-2-yl)-propan-2-yl-amino]butoxy]ethanoic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Wang, J.J, Jin, S, Zhang, H, Xu, Y, Hu, W, Jiang, Y, Chen, C, Wang, D.W, Xu, H.E, Wu, C. | | 登録日 | 2023-11-23 | | 公開日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Molecular recognition and activation of the prostacyclin receptor by anti-pulmonary arterial hypertension drugs.
Sci Adv, 10, 2024
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8X72
 | | The Crystal Structure of PLK1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Wang, F, Cheng, W, Yuan, Z, Lin, D, Wu, B. | | 登録日 | 2023-11-22 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Crystal Structure of PLK1 from Biortus.
To Be Published
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9FST
 | | Yeast 20S proteasome with human beta1i (1-51) in complex with epoxyketone inhibitor LU-001i | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, MAGNESIUM ION, ... | | 著者 | Maurits, E, Huber, E.M, Dekker, P.M, Wang, X, Heinemeyer, W, Florea, B.I, Groll, M, Overkleeft, H.S. | | 登録日 | 2024-06-21 | | 公開日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure-based design of peptide epoxyketones selectively targeting the three human immunoproteasome active sites
To Be Published
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9FT0
 | | Yeast 20S proteasome in complex with epoxyketone inhibitor 42 | | 分子名称: | (2S)-N-[(2S)-1-[[(1S)-2-cyclohexyl-1-[(2R,3S,6R,7S)-3-methanoyl-2,6-dimethyl-6,7-bis(oxidanyl)-1,4-oxazepan-7-yl]ethyl]amino]-3-(4-methoxyphenyl)-1-oxidanylidene-propan-2-yl]-2-(2-morpholin-4-ylethanoylamino)-4-oxidanyl-butanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CHLORIDE ION, ... | | 著者 | Maurits, E, Huber, E.M, Dekker, P.M, Wang, X, Heinemeyer, W, Florea, B.I, Groll, M, Overkleeft, H.S. | | 登録日 | 2024-06-23 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-07-17 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structure-based design of peptide epoxyketones selectively targeting the three human immunoproteasome active sites
to be published
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8XNH
 | | Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 5C8 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 5C8-VH, 5C8-VL, ... | | 著者 | Fan, P.F, Ren, Y, Yu, C.M, Chen, W. | | 登録日 | 2023-12-30 | | 公開日 | 2024-07-10 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Nipah virus fusion glycoprotein in complex with a broadly neutralizing antibody 1D6
To Be Published
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8XB9
 | | The Crystal Structure of polo-box domain of PLK1 from Biortus. | | 分子名称: | 1,2-ETHANEDIOL, Serine/threonine-protein kinase PLK1 | | 著者 | Wang, F, Cheng, W, Yuan, Z, Meng, Q, Zhang, B. | | 登録日 | 2023-12-06 | | 公開日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | The Crystal Structure of polo-box domain of PLK1 from Biortus
To Be Published
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9B8Y
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8X2S
 | | The Crystal Structure of BPGM from Biortus | | 分子名称: | 1,2-ETHANEDIOL, Bisphosphoglycerate mutase | | 著者 | Wang, F, Cheng, W, Yuan, Z, Qi, J, Li, J. | | 登録日 | 2023-11-10 | | 公開日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The Crystal Structure of BPGM from Biortus
To Be Published
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