1OP8
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![BU of 1op8 by Molmil](/molmil-images/mine/1op8) | Crystal Structure of Human Granzyme A | Descriptor: | Granzyme A, SULFATE ION | Authors: | Hink-Schauer, C, Estebanez-Perpina, E, Bode, W, Jenne, D. | Deposit date: | 2003-03-05 | Release date: | 2003-07-01 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Crystal structure of the apoptosis-inducing human granzyme A dimer NAT.STRUCT.BIOL., 10, 2003
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7Z0Z
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![BU of 7z0z by Molmil](/molmil-images/mine/7z0z) | Abortive infection DNA polymerase AbiK from Lactococcus lactis, Y44F variant | Descriptor: | AbiK | Authors: | Figiel, M, Gapinska, M, Czarnocki-Cieciura, M, Zajko, W, Nowotny, M. | Deposit date: | 2022-02-24 | Release date: | 2022-09-07 | Last modified: | 2022-10-05 | Method: | ELECTRON MICROSCOPY (2.68 Å) | Cite: | Mechanism of protein-primed template-independent DNA synthesis by Abi polymerases. Nucleic Acids Res., 50, 2022
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3I3G
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![BU of 3i3g by Molmil](/molmil-images/mine/3i3g) | Crystal Structure of Trypanosoma brucei N-acetyltransferase (Tb11.01.2886) at 1.86A | Descriptor: | N-acetyltransferase | Authors: | Qiu, W, Wernimont, A.K, Marino, K, Zhang, A.Z, Ma, D, Lin, Y.H, Mackenzie, F, Kozieradzki, I, Cossar, D, Zhao, Y, Schapira, M, Bochkarev, A, Arrowsmith, C.H, Bountra, C, Weigelt, J, Edwards, A.M, J Ferguson, M.A, Hui, R, Structural Genomics Consortium (SGC) | Deposit date: | 2009-06-30 | Release date: | 2009-08-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.86 Å) | Cite: | Crystal Structure Trypanosoma brucei N-acetyltransferase (Tb11.01.2886) at 1.86A To be Published
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1OWD
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![BU of 1owd by Molmil](/molmil-images/mine/1owd) | Substituted 2-Naphthamidine inhibitors of urokinase | Descriptor: | 6-[AMINO(IMINO)METHYL]-N-[(4R)-4-ETHYL-1,2,3,4-TETRAHYDROISOQUINOLIN-6-YL]-2-NAPHTHAMIDE, Urokinase-type plasminogen activator | Authors: | Wendt, M.D, Rockway, T.W, Geyer, A, McClellan, W, Weitzberg, M, Zhao, X, Mantei, R, Nienaber, V.L, Stewart, K, Klinghofer, V, Giranda, V.L. | Deposit date: | 2003-03-28 | Release date: | 2003-09-30 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (2.32 Å) | Cite: | Identification of Novel Binding Interactions in the Development of Potent, Selective 2-Naphthamidine Inhibitors of Urokinase. Synthesis, Structural Analysis, and SAR of N-Phenyl Amide 6-Substitution. J.Med.Chem., 47, 2004
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3ELK
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![BU of 3elk by Molmil](/molmil-images/mine/3elk) | Crystal structure of putative transcriptional regulator TA0346 from Thermoplasma acidophilum | Descriptor: | CHLORIDE ION, Putative transcriptional regulator TA0346 | Authors: | Grantz Saskova, K, Chruszcz, M, Evdokimova, E, Egorova, O, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2008-09-22 | Release date: | 2008-09-30 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Crystal structure of putative transcriptional regulator TA0346 from Thermoplasma acidophilum To be Published
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3HRB
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![BU of 3hrb by Molmil](/molmil-images/mine/3hrb) | p38 kinase Crystal structure in complex with small molecule inhibitor | Descriptor: | Mitogen-activated protein kinase 14, [3-amino-2-(2-methylphenyl)-1-oxidopyridin-4-yl](2,4-difluorophenyl)methanone | Authors: | Segarra, V, Lumeras, W, Vidal, B, Leonard, P, Fisher, M, Lamers, M. | Deposit date: | 2009-06-09 | Release date: | 2009-09-01 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase J.Med.Chem., 52, 2009
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3ET1
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7V4Y
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![BU of 7v4y by Molmil](/molmil-images/mine/7v4y) | TTHA1264/TTHA1265 complex | Descriptor: | Putative zinc protease, ZINC ION, Zinc-dependent peptidase | Authors: | Xu, M, Xu, Q, Ran, T, Wang, W, Sun, B, Wang, Q. | Deposit date: | 2021-08-16 | Release date: | 2022-06-29 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal structures of TTHA1265 and TTHA1264/TTHA1265 complex reveal an intrinsic heterodimeric assembly. Int.J.Biol.Macromol., 207, 2022
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1ORW
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![BU of 1orw by Molmil](/molmil-images/mine/1orw) | Crystal Structure of Porcine Dipeptidyl Peptidase IV (CD26) in Complex with a Peptidomimetic Inhibitor | Descriptor: | (2S)-PYRROLIDIN-2-YLMETHYLAMINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Engel, M, Hoffmann, T, Wagner, L, Wermann, M, Heiser, U, Kiefersauer, R, Huber, R, Bode, W, Demuth, H.U, Brandstetter, H. | Deposit date: | 2003-03-16 | Release date: | 2003-05-06 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.84 Å) | Cite: | The Crystal Structure of Dipeptidyl Peptidase IV (CD26) Reveals its Functional Regulation and Enzymatic Mechanism Proc.Natl.Acad.Sci.USA, 100, 2003
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3F5V
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![BU of 3f5v by Molmil](/molmil-images/mine/3f5v) | C2 Crystal form of mite allergen DER P 1 | Descriptor: | CALCIUM ION, Der p 1 allergen, HEXAETHYLENE GLYCOL | Authors: | Stura, E.A, Minor, W, Chruszcz, M, Saint Remy, J.M. | Deposit date: | 2008-11-04 | Release date: | 2009-02-10 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.36 Å) | Cite: | Crystal structures of mite allergens Der f 1 and Der p 1 reveal differences in surface-exposed residues that may influence antibody binding. J.Mol.Biol., 386, 2009
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7YXA
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![BU of 7yxa by Molmil](/molmil-images/mine/7yxa) | XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... | Authors: | Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. | Deposit date: | 2022-02-15 | Release date: | 2022-08-10 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors. Nat Commun, 13, 2022
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3I4P
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![BU of 3i4p by Molmil](/molmil-images/mine/3i4p) | Crystal structure of AsnC family transcriptional regulator from Agrobacterium tumefaciens | Descriptor: | ACETATE ION, CALCIUM ION, CHLORIDE ION, ... | Authors: | Cymborowski, M, Chruszcz, M, Luo, H, Xu, X, Savchenko, A, Edwards, A, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-07-02 | Release date: | 2009-07-28 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of AsnC family transcriptional regulator from Agrobacterium tumefaciens To be Published
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3HS9
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![BU of 3hs9 by Molmil](/molmil-images/mine/3hs9) | Intersectin 1-peptide-AP2 beta ear complex | Descriptor: | AP-2 complex subunit beta-1, peptide from Intersectin-1, residues 841-851 | Authors: | Vahedi-Faridi, A, Pechstein, A, Schaefer, J.G, Saenger, W, Haucke, V. | Deposit date: | 2009-06-10 | Release date: | 2010-02-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Regulation of synaptic vesicle recycling by complex formation between intersectin 1 and the clathrin adaptor complex AP2. Proc.Natl.Acad.Sci.USA, 107, 2010
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3EZR
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![BU of 3ezr by Molmil](/molmil-images/mine/3ezr) | CDK-2 with indazole inhibitor 17 bound at its active site | Descriptor: | 3-methoxy-4-{3-[4-(4-methylpiperazin-1-yl)-1H-benzimidazol-2-yl]-1H-indazol-6-yl}aniline, Cell division protein kinase 2 | Authors: | Kiefer, J.R, Day, J.E, Caspers, N.L, Mathis, K.J, Kretzmer, K.K, Weinberg, R.A, Reitz, B.A, Stegeman, R.A, Trujillo, J.I, Huang, W, Thorarensen, A, Xing, L, Wrightstone, A, Christine, L, Compton, R, Li, X. | Deposit date: | 2008-10-23 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | 2-(6-Phenyl-1H-indazol-3-yl)-1H-benzo[d]imidazoles: Design and synthesis of a potent and isoform selective PKC-zeta inhibitor Bioorg.Med.Chem.Lett., 19, 2009
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1OPX
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![BU of 1opx by Molmil](/molmil-images/mine/1opx) | Crystal structure of the traffic ATPase (HP0525) of the Helicobacter pylori type IV secretion system bound by sulfate | Descriptor: | NONAETHYLENE GLYCOL, SULFATE ION, virB11 homolog | Authors: | Savvides, S.N, Yeo, H.J, Beck, M.R, Blaesing, F, Lurz, R, Lanka, E, Buhrdorf, R, Fischer, W, Haas, R, Waksman, G. | Deposit date: | 2003-03-06 | Release date: | 2003-05-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | VirB11 ATPases are dynamic hexameric assemblies: New insights into bacterial type IV secretion Embo J., 22, 2003
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3F2R
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![BU of 3f2r by Molmil](/molmil-images/mine/3f2r) | Crystal structure of human choline kinase alpha in complex with hemicholinium-3 | Descriptor: | (2S,2'S)-2,2'-biphenyl-4,4'-diylbis(2-hydroxy-4,4-dimethylmorpholin-4-ium), Choline kinase alpha, UNKNOWN ATOM OR ION | Authors: | Hong, B, Tempel, W, Rabeh, W.M, MacKenzie, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-10-30 | Release date: | 2008-11-11 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal structure of human choline kinase alpha in complex with hemicholinium-3 To be Published
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1OT3
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![BU of 1ot3 by Molmil](/molmil-images/mine/1ot3) | Crystal structure of Drosophila deoxyribonucleotide kinase complexed with the substrate deoxythymidine | Descriptor: | Deoxyribonucleoside Kinase, SULFATE ION, THYMIDINE | Authors: | Mikkelsen, N.E, Johansson, K, Karlsson, A, Knecht, W, Andersen, G, Piskur, J, Munch-Petersen, B, Eklund, H. | Deposit date: | 2003-03-21 | Release date: | 2003-05-27 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural Basis for Feedback Inhibition of the Deoxyribonucleoside Salvage Pathway: Studies of the Drosophila Deoxyribonucleoside Kinase. Biochemistry, 42, 2003
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3HXB
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![BU of 3hxb by Molmil](/molmil-images/mine/3hxb) | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 6) | Descriptor: | Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, N-[(benzyloxy)carbonyl]-D-tyrosyl-L-phenylalanyl-L-tyrosine, ... | Authors: | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | Deposit date: | 2009-06-20 | Release date: | 2009-09-08 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.25 Å) | Cite: | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
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2JUV
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![BU of 2juv by Molmil](/molmil-images/mine/2juv) | AbaA3-DKP-insulin | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Huang, K, Chan, S, Hua, Q, Chu, Y, Wang, R, Klaproth, B, Jia, W, Whittaker, J, De Meyts, P, Nakagawa, S.H, Steiner, D.F, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 2007-09-05 | Release date: | 2007-10-16 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | The A-chain of Insulin Contacts the Insert Domain of the Insulin Receptor: PHOTO-CROSS-LINKING AND MUTAGENESIS OF A DIABETES-RELATED CREVICE. J.Biol.Chem., 282, 2007
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3F7T
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![BU of 3f7t by Molmil](/molmil-images/mine/3f7t) | Structure of active IspH shows a novel fold with a [3Fe-4S] cluster in the catalytic centre | Descriptor: | 4-hydroxy-3-methylbut-2-enyl diphosphate reductase, FE3-S4 CLUSTER, PHOSPHATE ION, ... | Authors: | Graewert, T, Eppinger, J, Rohdich, F, Bacher, A, Eisenreich, W, Groll, M. | Deposit date: | 2008-11-10 | Release date: | 2009-07-07 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure of active IspH enzyme from Escherichia coli provides mechanistic insights into substrate reduction. Angew.Chem.Int.Ed.Engl., 48, 2009
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3F1J
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![BU of 3f1j by Molmil](/molmil-images/mine/3f1j) | Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals RNA binding properties | Descriptor: | CYTIDINE-5'-MONOPHOSPHATE, Matrix protein, SULFATE ION | Authors: | Neumann, P, Lieber, D, Meyer, S, Dautel, P, Kerth, A, Kraus, I, Garten, W, Stubbs, M.T. | Deposit date: | 2008-10-28 | Release date: | 2009-02-03 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Crystal structure of the Borna disease virus matrix protein (BDV-M) reveals ssRNA binding properties Proc.Natl.Acad.Sci.USA, 106, 2009
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2JPC
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3FK2
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![BU of 3fk2 by Molmil](/molmil-images/mine/3fk2) | Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1 | Descriptor: | Glucocorticoid receptor DNA-binding factor 1, UNKNOWN ATOM OR ION | Authors: | Nedyalkova, L, Tong, Y, Tempel, W, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2008-12-15 | Release date: | 2008-12-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the RhoGAP domain of human glucocorticoid receptor DNA-binding factor 1 To be Published
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3HTQ
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![BU of 3htq by Molmil](/molmil-images/mine/3htq) | the hemagglutinin structure of an avian H1N1 influenza A virus in complex with LSTc | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Hemagglutinin, ... | Authors: | Wang, G, Li, A, Zhang, Q, Wu, C, Zhang, R, Cai, Q, Song, W, Yuen, K.-Y. | Deposit date: | 2009-06-12 | Release date: | 2009-08-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.955 Å) | Cite: | The hemagglutinin structure of an avian H1N1 influenza A virus Virology, 392, 2009
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7YOA
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![BU of 7yoa by Molmil](/molmil-images/mine/7yoa) | |