4OJX
 
 | | crystal structure of yeast phosphodiesterase-1 in complex with GMP | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, 3',5'-cyclic-nucleotide phosphodiesterase 1, GUANOSINE-5'-MONOPHOSPHATE, ... | | Authors: | Tian, Y, Cui, W, Huang, M, Robinson, H, Wan, Y, Wang, Y, Ke, H. | | Deposit date: | 2014-01-21 | | Release date: | 2014-12-03 | | Last modified: | 2024-02-28 | | Method: | X-RAY DIFFRACTION (1.31 Å) | | Cite: | Dual specificity and novel structural folding of yeast phosphodiesterase-1 for hydrolysis of second messengers cyclic adenosine and guanosine 3',5'-monophosphate.
Biochemistry, 53, 2014
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3OE9
 | | Crystal structure of the chemokine CXCR4 receptor in complex with a small molecule antagonist IT1t in P1 spacegroup | | Descriptor: | (6,6-dimethyl-5,6-dihydroimidazo[2,1-b][1,3]thiazol-3-yl)methyl N,N'-dicyclohexylimidothiocarbamate, C-X-C chemokine receptor type 4, Lysozyme Chimera | | Authors: | Wu, B, Mol, C.D, Han, G.W, Katritch, V, Chien, E.Y.T, Liu, W, Cherezov, V, Stevens, R.C, Accelerated Technologies Center for Gene to 3D Structure (ATCG3D), GPCR Network (GPCR) | | Deposit date: | 2010-08-12 | | Release date: | 2010-10-27 | | Last modified: | 2021-10-06 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.
Science, 330, 2010
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2PM4
 | | Human alpha-defensin 1 (multiple Arg->Lys mutant) | | Descriptor: | Neutrophil defensin 1 (HNP-1) (HP-1) (HP1) (Defensin, alpha 1) | | Authors: | Lubkowski, J, Pazgier, M, Lu, W. | | Deposit date: | 2007-04-20 | | Release date: | 2007-05-29 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.95 Å) | | Cite: | Toward understanding the cationicity of defensins. Arg and Lys versus their noncoded analogs.
J.Biol.Chem., 282, 2007
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2PMI
 | | Structure of the Pho85-Pho80 CDK-cyclin Complex of the Phosphate-responsive Signal Transduction Pathway with Bound ATP-gamma-S | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Cyclin-dependent protein kinase PHO85, PHO85 cyclin PHO80, ... | | Authors: | Huang, K, Ferrin-O'Connell, I, Zhang, W, Leonard, G.A, O'Shea, E.K, Quiocho, F.A. | | Deposit date: | 2007-04-23 | | Release date: | 2007-12-11 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of the Pho85-Pho80 CDK-Cyclin Complex of the Phosphate-Responsive Signal Transduction Pathway
Mol.Cell, 28, 2007
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5V7Z
 | | SSNMR Structure of the Human RIP1/RIP3 Necrosome | | Descriptor: | PRO-LEU-VAL-ASN-ILE-TYR-ASN-CYS-SER-GLY-VAL-GLN-VAL-GLY-ASP, THR-ILE-TYR-ASN-SER-THR-GLY-ILE-GLN-ILE-GLY-ALA-TYR-ASN-TYR-MET-GLU-ILE | | Authors: | Mompean, M, Li, W, Li, J, Laage, S, Siemer, A.B, Wu, H, McDermott, A.E. | | Deposit date: | 2017-03-21 | | Release date: | 2018-03-28 | | Last modified: | 2024-05-01 | | Method: | SOLID-STATE NMR | | Cite: | The Structure of the Necrosome RIPK1-RIPK3 Core, a Human Hetero-Amyloid Signaling Complex.
Cell, 173, 2018
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2PK8
 | | Crystal structure of an uncharacterized protein PF0899 from Pyrococcus furiosus | | Descriptor: | GOLD (I) CYANIDE ION, Uncharacterized protein PF0899 | | Authors: | Liu, Z.J, Tempel, W, Chen, L, Shah, A, Lee, D, Clancy-Kelley, L.L, Dillard, B.D, Rose, J.P, Sugar, F.J, Jenny Jr, F.E, Lee, H.S, Izumi, M, Shah, C, Poole III, F.L, Adams, M.W.W, Richardson, J.S, Richardson, D.C, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | | Deposit date: | 2007-04-17 | | Release date: | 2007-05-22 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Structure of the hypothetical protein PF0899 from Pyrococcus furiosus at 1.85 A resolution.
Acta Crystallogr.,Sect.F, 63, 2007
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2PWQ
 | | Crystal structure of a putative ubiquitin conjugating enzyme from Plasmodium yoelii | | Descriptor: | Ubiquitin conjugating enzyme | | Authors: | Qiu, W, Dong, A, Hassanali, A, Lin, L, Brokx, S, Altamentova, S, Hills, T, Lew, J, Ravichandran, M, Kozieradzki, I, Zhao, Y, Schapira, M, Edwards, A.M, Arrowsmith, C.H, Weigelt, J, Sundstrom, M, Bochkarev, A, Hui, R, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-05-11 | | Release date: | 2007-05-22 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of a putative ubiquitin conjugating enzyme from Plasmodium yoelii.
To be Published
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2PFR
 | | Human N-acetyltransferase 2 | | Descriptor: | Arylamine N-acetyltransferase 2, COENZYME A, SULFATE ION, ... | | Authors: | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Grant, D.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-04-05 | | Release date: | 2007-05-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.92 Å) | | Cite: | The Crystal Structure of Human N-acetyltransferase 2 in complex with CoA
to be published
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1RN4
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2PO7
 | | Crystal structure of human ferrochelatase mutant with His 341 replaced by Cys | | Descriptor: | CHOLIC ACID, FE2/S2 (INORGANIC) CLUSTER, Ferrochelatase, ... | | Authors: | Dailey, H.A, Wu, C.-K, Horanyi, P, Medlock, A.E, Najahi-Missaoui, W, Burden, A, Dailey, T.A, Rose, J.P. | | Deposit date: | 2007-04-25 | | Release date: | 2007-10-02 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Altered orientation of active site residues in variants of human ferrochelatase. Evidence for a hydrogen bond network involved in catalysis.
Biochemistry, 46, 2007
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3MVT
 | | Crystal structure of apo mADA at 2.2A resolution | | Descriptor: | Adenosine deaminase, CHLORIDE ION, GLYCEROL | | Authors: | Niu, W, Shu, Q, Chen, Z, Mathews, S, Di Cera, E, Frieden, C. | | Deposit date: | 2010-05-04 | | Release date: | 2010-10-13 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | The role of Zn2+ on the structure and stability of murine adenosine deaminase.
J.Phys.Chem.B, 114, 2010
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2PQ8
 | | MYST histone acetyltransferase 1 | | Descriptor: | COENZYME A, Probable histone acetyltransferase MYST1, UNKNOWN ATOM OR ION, ... | | Authors: | Tempel, W, Wu, H, Dombrovski, L, Loppnau, P, Weigelt, J, Sundstrom, M, Arrowsmith, C.H, Edwards, A.M, Bochkarev, A, Plotnikov, A.N, Structural Genomics Consortium (SGC) | | Deposit date: | 2007-05-01 | | Release date: | 2007-05-15 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | MYST histone acetyltransferase 1.
To be Published
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3T9Z
 | | A. fulgidus GlnK3, ligand-free | | Descriptor: | CITRATE ANION, Nitrogen regulatory protein P-II (GlnB-3) | | Authors: | Maier, S, Schleberger, P, Lue, W, Wacker, T, Pflueger, T, Litz, C, Andrade, S.L.A. | | Deposit date: | 2011-08-03 | | Release date: | 2011-10-26 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | Mechanism of disruption of the Amt-GlnK complex by P(II)-mediated sensing of 2-oxoglutarate.
Plos One, 6, 2011
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4OX3
 | | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition | | Descriptor: | PHOSPHATE ION, Putative carboxypeptidase YodJ, ZINC ION | | Authors: | Hoyland, C.N, Aldridge, C, Cleverley, R.M, Sidiq, K, Duchene, M.C, Daniel, R.A, Vollmer, W, Lewis, R.J. | | Deposit date: | 2014-02-04 | | Release date: | 2014-06-11 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition.
Structure, 22, 2014
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3MXN
 | | Crystal structure of the RMI core complex | | Descriptor: | BENZAMIDINE, RecQ-mediated genome instability protein 1, RecQ-mediated genome instability protein 2 | | Authors: | Hoadley, K.A, Xu, D, Xue, Y, Satyshur, K.A, Wang, W, Keck, J.L. | | Deposit date: | 2010-05-07 | | Release date: | 2010-09-15 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (1.55 Å) | | Cite: | Structure and cellular roles of the RMI core complex from the bloom syndrome dissolvasome.
Structure, 18, 2010
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1RT8
 | | CRYSTAL STRUCTURE OF THE ACTIN-CROSSLINKING CORE OF SCHIZOSACCHAROMYCES POMBE FIMBRIN | | Descriptor: | SULFATE ION, fimbrin | | Authors: | Klein, M.G, Shi, W, Ramagopal, U, Tseng, Y, Wirtz, D, Kovar, D.R, Staiger, C.J, Almo, S.C. | | Deposit date: | 2003-12-10 | | Release date: | 2004-06-22 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structure of the actin crosslinking core of fimbrin.
Structure, 12, 2004
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4PQD
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3TDM
 | | Computationally designed TIM-barrel protein, HalfFLR | | Descriptor: | Computationally designed two-fold symmetric TIM-barrel protein, FLR (half molecule), PHOSPHATE ION | | Authors: | Harp, J.M, Fortenberry, C, Bowman, E, Profitt, W, Dorr, B, Mizoue, L. | | Deposit date: | 2011-08-11 | | Release date: | 2011-11-16 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
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1RR6
 | | Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and phosphate | | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, PHOSPHATE ION, Purine nucleoside phosphorylase | | Authors: | Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L. | | Deposit date: | 2003-12-08 | | Release date: | 2005-02-22 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Plasmodium falciparum purine nucleoside phosphorylase: crystal structures, immucillin inhibitors, and dual catalytic function.
J.Biol.Chem., 279, 2004
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3MVG
 | | Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A | | Descriptor: | GLYCEROL, Ribosome inactivating type 1 protein, SULFATE ION | | Authors: | Meyer, A, Weber, W, Singh, T.P, Betzel, C. | | Deposit date: | 2010-05-04 | | Release date: | 2011-06-01 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.25 Å) | | Cite: | Native structure of IRIP, a type I ribosome inactivating protein from Iris hollandica var. at 1.25 A
to be published
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1RVK
 | | Crystal structure of enolase AGR_L_2751 from Agrobacterium Tumefaciens | | Descriptor: | MAGNESIUM ION, isomerase/lactonizing enzyme | | Authors: | Fedorov, A.A, Fedorov, E.V, Thirumuruhan, R, Zencheck, W, Millikin, C, Gerlt, J.A, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | Deposit date: | 2003-12-14 | | Release date: | 2003-12-23 | | Last modified: | 2021-02-03 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Evolution of enzymatic activites in the Enolase superfamily: 1.7 A crystal structure of the hypothetical protein MR.GI-17937161 from Agrobacterium tumefaciens
To be Published
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1RT9
 | | Structure of human purine nucleoside phosphorylase in complex with Immucillin-H and sulfate | | Descriptor: | 1,4-DIDEOXY-4-AZA-1-(S)-(9-DEAZAHYPOXANTHIN-9-YL)-D-RIBITOL, Purine nucleoside phosphorylase, SULFATE ION | | Authors: | Shi, W, Lewandowicz, A, Tyler, P.C, Furneaux, R.H, Almo, S.C, Schramm, V.L. | | Deposit date: | 2003-12-10 | | Release date: | 2005-02-22 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Structural comparison of human and malarial purine nucleoside phosphorylases
To be Published
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4PNQ
 | | Crystal Structure of human Tankyrase 2 in complex with 5AIQ. | | Descriptor: | 5-aminoisoquinolin-1(4H)-one, ISOPROPYL ALCOHOL, Tankyrase-2, ... | | Authors: | Qiu, W, Lam, R, Romanov, V, Gordon, R, Gebremeskel, S, Vodsedalek, J, Thompson, C, Beletskaya, I, Battaile, K.P, Pai, E.F, Chirgadze, N.Y. | | Deposit date: | 2014-05-24 | | Release date: | 2014-10-15 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Insights into the binding of PARP inhibitors to the catalytic domain of human tankyrase-2.
Acta Crystallogr.,Sect.D, 70, 2014
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2O52
 | | Crystal structure of human RAB4B in complex with GDP | | Descriptor: | BETA-MERCAPTOETHANOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Zhu, H, Tempel, W, Wang, J, Shen, Y, Landry, R, Arrowsmith, C.H, Edwards, A.M, Sundstrom, M, Weigelt, J, Bochkarev, A, Park, H, Structural Genomics Consortium (SGC) | | Deposit date: | 2006-12-05 | | Release date: | 2006-12-19 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of human RAB4B in complex with GDP
To be Published
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4POZ
 | | Fab fragment of Der p 1 specific antibody 10B9 | | Descriptor: | heavy chain of Fab fragment of 10B9 antibody, light chain of Fab fragment of 10B9 antibody | | Authors: | Osinski, T, Majorek, K.A, Pomes, A, Offermann, L.R, Osinski, S, Glesner, J, Vailes, L.D, Chapman, M.D, Minor, W, Chruszcz, M. | | Deposit date: | 2014-02-26 | | Release date: | 2015-04-08 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural Analysis of Der p 1-Antibody Complexes and Comparison with Complexes of Proteins or Peptides with Monoclonal Antibodies.
J. Immunol., 195, 2015
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