6L12
| Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | 分子名称: | 4-[(2-chloranylphenoxazin-10-yl)methyl]cyclohexan-1-amine, Serine/threonine-protein kinase pim-1 | 著者 | Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. | 登録日 | 2019-09-27 | 公開日 | 2020-05-27 | 最終更新日 | 2020-07-08 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
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5XTQ
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5XUO
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4LVA
| Fragment-based Identification of Amides Derived From trans-2-(Pyridin-3-yl)cyclopropanecarboxylic Acid as Potent Inhibitors of Human Nicotinamide Phosphoribosyltransferase (NAMPT) | 分子名称: | 1,2-ETHANEDIOL, N-(4-{[4-(pyrrolidin-1-yl)piperidin-1-yl]sulfonyl}benzyl)-2H-pyrido[4,3-e][1,2,4]thiadiazin-3-amine 1,1-dioxide, Nicotinamide phosphoribosyltransferase, ... | 著者 | Giannetti, A.M, Zheng, X, Skelton, N, Wang, W, Bravo, B, Feng, Y, Gunzner-Toste, J, Ho, Y, Hua, R, Wang, C, Zhao, Q, Liederer, B.M, Liu, Y, O'Brien, T, Oeh, J, Sampath, D, Shen, Y, Wang, L, Wu, H, Xiao, Y, Yuen, P, Zak, M, Zhao, G, Dragovich, P.S. | 登録日 | 2013-07-26 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Identification of amides derived from 1H-pyrazolo[3,4-b]pyridine-5-carboxylic acid as potent inhibitors of human nicotinamide phosphoribosyltransferase (NAMPT). Bioorg.Med.Chem.Lett., 23, 2013
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1ZWW
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5YFP
| Cryo-EM Structure of the Exocyst Complex | 分子名称: | Exocyst complex component EXO70, Exocyst complex component EXO84, Exocyst complex component SEC10, ... | 著者 | Mei, K, Li, Y, Wang, S, Shao, G, Wang, J, Ding, Y, Luo, G, Yue, P, Liu, J.J, Wang, X, Dong, M.Q, Guo, W, Wang, H.W. | 登録日 | 2017-09-21 | 公開日 | 2018-01-31 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Cryo-EM structure of the exocyst complex Nat. Struct. Mol. Biol., 25, 2018
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4M69
| Crystal structure of the mouse RIP3-MLKL complex | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Mixed lineage kinase domain-like protein, ... | 著者 | Xie, T, Peng, W, Yan, C, Wu, J, Shi, Y. | 登録日 | 2013-08-09 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (2.497 Å) | 主引用文献 | Structural Insights into RIP3-Mediated Necroptotic Signaling Cell Rep, 5, 2013
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1ZVA
| A structure-based mechanism of SARS virus membrane fusion | 分子名称: | E2 glycoprotein | 著者 | Deng, Y, Liu, J, Zheng, Q, Yong, W, Dai, J, Lu, M. | 登録日 | 2005-06-01 | 公開日 | 2006-05-16 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structures and Polymorphic Interactions of Two Heptad-Repeat Regions of the SARS Virus S2 Protein. Structure, 14, 2006
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1ZQ5
| Crystal structure of human androgenic 17beta-hydroxysteroid dehydrogenase type 5 in complexed with a potent inhibitor EM1404 | 分子名称: | 3-CARBOXAMIDO-1,3,5(10)-ESTRATRIEN-17(R)-SPIRO-2'(5',5'-DIMETHYL-6'OXO)TETRAHYDROPYRAN, ACETATE ION, Aldo-keto reductase family 1 member C3, ... | 著者 | Qiu, W, Zhou, M, Ghanmi, D, Luu-The, V, Labrie, F, Lin, S.X. | 登録日 | 2005-05-18 | 公開日 | 2006-12-12 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structure-based inhibitor design for an enzyme that binds different steroids: a potent inhibitor for human type 5 17beta-hydroxysteroid dehydrogenase. J.Biol.Chem., 282, 2007
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4M1C
| Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) | 分子名称: | Amyloid beta A4 protein, Fab-bound IDE, heavy chain, ... | 著者 | McCord, L.M, Liang, W, Farcasanu, M, Scherpelz, K, Meredith, S.C, Koide, S, Tang, W.J. | 登録日 | 2013-08-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.5007 Å) | 主引用文献 | Crystal Structure Analysis of Fab-Bound Human Insulin Degrading Enzyme (IDE) in Complex with Amyloid-Beta (1-40) To be Published
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5Y2W
| Structure of Synechocystis PCC6803 CcmR regulatory domain in complex with 2-PG | 分子名称: | 2-PHOSPHOGLYCOLIC ACID, Rubisco operon transcriptional regulator | 著者 | Jiang, Y.L, Wang, X.P, Sun, H, Cheng, W, Cao, D.D, Han, S.J, Li, W.F, Chen, Y, Zhou, C.Z. | 登録日 | 2017-07-27 | 公開日 | 2017-12-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Coordinating carbon and nitrogen metabolic signaling through the cyanobacterial global repressor NdhR. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4MGA
| Crystal structure of hERa-LBD (Y537S) in complex with 4-tert-octylphenol | 分子名称: | 4-(2,4,4-trimethylpentan-2-yl)phenol, Estrogen receptor, Nuclear receptor coactivator 1 | 著者 | Delfosse, V, Grimaldi, M, Bourguet, W. | 登録日 | 2013-08-28 | 公開日 | 2014-09-03 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
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1ZR4
| Structure of a Synaptic gamma-delta Resolvase Tetramer Covalently linked to two Cleaved DNAs | 分子名称: | AAA, TCAGTGTCCGATAATTTAT, TTATCGGACACTG, ... | 著者 | Li, W, Kamtekar, S, Xiong, Y, Sarkis, G.J, Grindley, N.D, Steitz, T.A. | 登録日 | 2005-05-19 | 公開日 | 2005-08-30 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (3.4 Å) | 主引用文献 | Structure of a synaptic gamma delta resolvase tetramer covalently linked to two cleaved DNAs. Science, 309, 2005
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278D
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1ZQ7
| X-Ray Crystal Structure of Protein Q8PZK8 from Methanosarcina mazei. Northeast Structural Genomics Consortium Target MaR9. | 分子名称: | Hypothetical protein MM0484 | 著者 | Kuzin, A.P, Abashidze, M, Vorobiev, S.M, Yong, W, Xiao, R, Ma, L.-C, Acton, T, Montelione, G.T, Tong, L, Hunt, J, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2005-05-18 | 公開日 | 2005-05-31 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | 主引用文献 | X-Ray structure of the hypothetical protein Q8PZK8 from Methanosarcina mazei at the resolution 2.1A. Northeast Structural Genomics Consortium target MaR9. To be Published
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4MER
| Crystal structure of the novel protein and virulence factor sHIP (Q99XU0) from Streptococcus pyogenes | 分子名称: | streptococcal Histidine-rich glycoprotein Interacting Protein | 著者 | Wisniewska, M, Happonen, L, Frick, M.-I, Bjorck, L, Streicher, W, Malmstrom, J, Wikstrom, M. | 登録日 | 2013-08-27 | 公開日 | 2014-05-21 | 最終更新日 | 2014-07-16 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | Functional and Structural Properties of a Novel Protein and Virulence Factor (Protein sHIP) in Streptococcus pyogenes. J.Biol.Chem., 289, 2014
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5YAZ
| Crystal structure of the ANKRD domain of KANK1 | 分子名称: | ACETATE ION, KN motif and ankyrin repeat domains 1 | 著者 | Wei, Z, Pan, W. | 登録日 | 2017-09-02 | 公開日 | 2017-12-20 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural insights into ankyrin repeat-mediated recognition of the kinesin motor protein KIF21A by KANK1, a scaffold protein in focal adhesion. J. Biol. Chem., 293, 2018
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4MHA
| Crystal structure of the catalytic domain of the proto-oncogene tyrosine-protein kinase MER in complex with inhibitor UNC1817 | 分子名称: | 2-(butylamino)-4-[(trans-4-hydroxycyclohexyl)amino]-N-(4-sulfamoylbenzyl)pyrimidine-5-carboxamide, CHLORIDE ION, MAGNESIUM ION, ... | 著者 | Zhang, W, Mciver, A, Stashko, M.A, Deryckere, D, Branchford, B.R, Hunter, D, Kireev, D.B, Miley, D.B.M, Norris-Drouin, J, Stewart, W.M, Lee, M, Sather, S, Zhou, Y, Dipaola, J.A, Machius, M, Janzen, W.P, Earp, H.S, Graham, D.K, Frye, S, Wang, X. | 登録日 | 2013-08-29 | 公開日 | 2014-05-21 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | 主引用文献 | Discovery of Mer specific tyrosine kinase inhibitors for the treatment and prevention of thrombosis. J.Med.Chem., 56, 2013
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1ZTD
| Hypothetical Protein Pfu-631545-001 From Pyrococcus furiosus | 分子名称: | Hypothetical Protein Pfu-631545-001 | 著者 | Fu, Z.-Q, Horanyi, P, Florence, Q, Liu, Z.-J, Chen, L, Lee, D, Habel, J, Xu, H, Nguyen, D, Chang, S.-H, Zhou, W, Zhang, H, Jenney Jr, F.E, Sha, B, Adams, M.W.W, Rose, J.P, Wang, B.-C, Southeast Collaboratory for Structural Genomics (SECSG) | 登録日 | 2005-05-26 | 公開日 | 2005-06-07 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Hypothetical Protein Pfu-631545-001 From Pyrococcus furiosus To be Published
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4MG5
| Crystal structure of hERa-LBD (Y537S) in complex with chlordecone | 分子名称: | Estrogen receptor, GLYCEROL, Nuclear receptor coactivator 1, ... | 著者 | Delfosse, V, Grimaldi, M, Bourguet, W. | 登録日 | 2013-08-28 | 公開日 | 2014-09-03 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Structural and functional profiling of environmental ligands for estrogen receptors. Environ.Health Perspect., 122, 2014
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6KWR
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1ZVI
| Rat Neuronal Nitric Oxide Synthase Oxygenase Domain | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric-oxide synthase, brain, ... | 著者 | Matter, H, Kumar, H.S, Fedorov, R, Frey, A, Kotsonis, P, Hartmann, E, Frohlich, L.G, Reif, A, Pfleiderer, W, Scheurer, P, Ghosh, D.K, Schlichting, I, Schmidt, H.H. | 登録日 | 2005-06-02 | 公開日 | 2005-08-02 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural Analysis of Isoform-Specific Inhibitors Targeting the Tetrahydrobiopterin Binding Site of Human Nitric Oxide Synthases. J.Med.Chem., 48, 2005
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6KYE
| The crystal structure of recombinant human adult hemoglobin | 分子名称: | CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | 著者 | Kihira, K, Funaki, R, Okamoto, W, Endo, C, Morita, Y, Komatsu, T. | 登録日 | 2019-09-18 | 公開日 | 2020-01-01 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Genetically engineered haemoglobin wrapped covalently with human serum albumins as an artificial O2carrier. J Mater Chem B, 8, 2020
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6L29
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6L16
| Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives | 分子名称: | 2-[4-[2-(7-chloranylpyrido[3,4-b][1,4]benzoxazin-5-yl)ethyl]piperidin-1-yl]ethanamine, Serine/threonine-protein kinase pim-1 | 著者 | Zhang, W, Xie, Y, Cao, R, Huang, N, Zhou, Y. | 登録日 | 2019-09-27 | 公開日 | 2020-05-27 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60, 2020
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