6L16

Crystal structure of Ser/Thr kinase Pim1 in complex with 10-DEBC derivatives

Summary for 6L16

Entry DOI	10.2210/pdb6l16/pdb
Descriptor	Serine/threonine-protein kinase pim-1, 2-[4-[2-(7-chloranylpyrido[3,4-b][1,4]benzoxazin-5-yl)ethyl]piperidin-1-yl]ethanamine (3 entities in total)
Functional Keywords	pim-1 kinase, 10-debc, transferase-inhibitor complex, transferase/inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	33665.61
Authors	Zhang, W.,Xie, Y.,Cao, R.,Huang, N.,Zhou, Y. (deposition date: 2019-09-27, release date: 2020-05-27, Last modification date: 2023-11-22)
Primary citation	Li, G.,Zhang, W.,Xie, Y.,Li, Y.,Cao, R.,Zheng, G.,Huang, N.,Zhou, Y. Structure-Based Optimization of 10-DEBC Derivatives as Potent and Selective Pim-1 Kinase Inhibitors. J.Chem.Inf.Model., 60:3287-3294, 2020 Cited by PubMed: 32407627 DOI: 10.1021/acs.jcim.0c00245 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation