4GQA
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![BU of 4gqa by Molmil](/molmil-images/mine/4gqa) | Crystal structure of NAD binding oxidoreductase from Klebsiella pneumoniae | Descriptor: | DI(HYDROXYETHYL)ETHER, GLYCEROL, NAD binding Oxidoreductase, ... | Authors: | Osinski, S, Majorek, K.A, Niedzialkowska, E, Osinski, T, Porebski, P.J, Nawar, A, Hammonds, J, Hillerich, B, Seidel, R, Bonanno, J.B, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2012-08-22 | Release date: | 2012-09-12 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.42 Å) | Cite: | Crystal structure of NAD binding oxidoreductase from Klebsiella pneumoniae (CASP Target) To be Published
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3SN5
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![BU of 3sn5 by Molmil](/molmil-images/mine/3sn5) | Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one | Descriptor: | (8ALPHA,9BETA)-CHOLEST-4-EN-3-ONE, Cholesterol 7-alpha-monooxygenase, PROTOPORPHYRIN IX CONTAINING FE, ... | Authors: | Strushkevich, N, Tempel, W, MacKenzie, F, Wernimont, A.K, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Park, H, Structural Genomics Consortium (SGC) | Deposit date: | 2011-06-28 | Release date: | 2011-07-13 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Crystal structure of human CYP7A1 in complex with cholest-4-en-3-one To be Published
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4GV9
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![BU of 4gv9 by Molmil](/molmil-images/mine/4gv9) | Lassa nucleoprotein C-terminal domain in complex with triphosphated dsRNA soaking for 5 min | Descriptor: | MANGANESE (II) ION, Nucleoprotein, RNA (5'-R(*(GTP)P*GP*GP*C)-3'), ... | Authors: | Jiang, X, Huang, Q, Wang, W, Dong, H, Ly, H, Liang, Y, Dong, C. | Deposit date: | 2012-08-30 | Release date: | 2013-05-01 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.46 Å) | Cite: | Structures of Arenaviral Nucleoproteins with Triphosphate dsRNA Reveal a Unique Mechanism of Immune Suppression. J.Biol.Chem., 288, 2013
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3S8F
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![BU of 3s8f by Molmil](/molmil-images/mine/3s8f) | 1.8 A structure of ba3 cytochrome c oxidase from Thermus thermophilus in lipid environment | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, COPPER (II) ION, Cytochrome c oxidase polypeptide 2A, ... | Authors: | Tiefenbrunn, T, Liu, W, Chen, Y, Katritch, V, Stout, C.D, Fee, J.A, Cherezov, V. | Deposit date: | 2011-05-27 | Release date: | 2011-08-03 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | High resolution structure of the ba3 cytochrome c oxidase from Thermus thermophilus in a lipidic environment. Plos One, 6, 2011
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4HZH
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![BU of 4hzh by Molmil](/molmil-images/mine/4hzh) | Structure of recombinant Gla-domainless prothrombin mutant S525A | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prothrombin | Authors: | Pozzi, N, Niu, W, Gohara, D.W, Chen, Z, Di Cera, E. | Deposit date: | 2012-11-15 | Release date: | 2013-06-26 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Crystal structure of prothrombin reveals conformational flexibility and mechanism of activation. J.Biol.Chem., 288, 2013
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4HXA
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![BU of 4hxa by Molmil](/molmil-images/mine/4hxa) | Crystal structure of 13D9 FAB | Descriptor: | 13D9 FAB HEAVY CHAIN, 13D9 FAB LIGHT CHAIN | Authors: | Johal, A.R, Jarrell, H.C, Khieu, N.H, Letts, J.A, Landry, R.C, Jachymek, W, Yang, Q, Jennings, H.J, Brisson, J.R, Evans, S.V. | Deposit date: | 2012-11-09 | Release date: | 2013-07-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | The antigen-binding site of an N-propionylated polysialic acid-specific antibody protective against group B meningococci is consistent with extended epitopes. Glycobiology, 23, 2013
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3S5A
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![BU of 3s5a by Molmil](/molmil-images/mine/3s5a) | ABH2 cross-linked to undamaged dsDNA-2 with cofactors | Descriptor: | 2-OXOGLUTARIC ACID, 5'-D(*CP*TP*GP*TP*CP*TP*CP*AP*CP*TP*GP*TP*CP*G)-3', 5'-D(*TP*CP*GP*AP*CP*AP*GP*TP*GP*AP*GP*AP*CP*A)-3', ... | Authors: | Yi, C, Chen, B, Qi, B, Ramirez, B, Zhang, W, Jia, G, Zhang, L, Li, C.Q, Dinner, A.R, Yang, C.-G, He, C. | Deposit date: | 2011-05-21 | Release date: | 2012-06-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Duplex interrogation by a direct DNA repair protein in search of base damage Nat.Struct.Mol.Biol., 19, 2012
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4I11
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![BU of 4i11 by Molmil](/molmil-images/mine/4i11) | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. | Descriptor: | Beta-secretase 1, N-(3,3-dimethyl-3,4-dihydroisoquinolin-1-yl)-L-phenylalanine, ZINC ION | Authors: | Bowers, B, Xu, Y, Yuan, S, Probst, G.D, Hom, R.K, Chan, W, Konradi, A.W, Sham, H.L, Zhu, Y.L, Beroza, P, Pan, H, Brecht, E, Yao, N, Lougheed, J, Artis, D.R, Tam, D, Bova, M. | Deposit date: | 2012-11-19 | Release date: | 2013-03-06 | Last modified: | 2013-04-24 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structure-based design of novel dihydroisoquinoline BACE-1 inhibitors that do not engage the catalytic aspartates. Bioorg.Med.Chem.Lett., 23, 2013
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4I6J
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![BU of 4i6j by Molmil](/molmil-images/mine/4i6j) | A ubiquitin ligase-substrate complex | Descriptor: | Cryptochrome-2, F-box/LRR-repeat protein 3, S-phase kinase-associated protein 1 | Authors: | Xing, W, Busino, L, Hinds, T.R, Marionni, S.T, Saifee, N.H, Bush, M.F, Pagano, M, Zheng, N. | Deposit date: | 2012-11-29 | Release date: | 2013-03-13 | Last modified: | 2013-05-01 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | SCFFBXL3 ubiquitin ligase targets cryptochromes at their cofactor pocket. Nature, 496, 2013
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4I76
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![BU of 4i76 by Molmil](/molmil-images/mine/4i76) | Crystal structure of transcriptional regulator TM1030 with octanol | Descriptor: | 1,2-ETHANEDIOL, OCTAN-1-OL, Transcriptional regulator, ... | Authors: | Koclega, K.D, Chruszcz, M, Cooper, D.R, Petkowski, J.J, Tkaczuk, K.L, Joachimiak, A, Minor, W, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2012-11-30 | Release date: | 2013-01-02 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of transcriptional regulator TM1030 with octanol To be Published
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3UA4
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![BU of 3ua4 by Molmil](/molmil-images/mine/3ua4) | Crystal Structure of Protein Arginine Methyltransferase PRMT5 | Descriptor: | GLYCEROL, Protein arginine N-methyltransferase 5 | Authors: | Sun, L, Wang, M, Lv, Z, Yang, N, Liu, Y, Bao, S, Gong, W, Xu, R.M. | Deposit date: | 2011-10-21 | Release date: | 2011-12-14 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.005 Å) | Cite: | Structural insights into protein arginine symmetric dimethylation by PRMT5 Proc.Natl.Acad.Sci.USA, 108, 2011
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3TJM
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![BU of 3tjm by Molmil](/molmil-images/mine/3tjm) | Crystal Structure of the Human Fatty Acid Synthase Thioesterase Domain with an Activate Site-Specific Polyunsaturated Fatty Acyl Adduct | Descriptor: | Fatty acid synthase, methyl (R)-(6Z,9Z,12Z)-octadeca-6,9,12-trien-1-ylphosphonofluoridate | Authors: | Zhang, W, Zheng, F, Florante, A.Q. | Deposit date: | 2011-08-24 | Release date: | 2011-09-28 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.48 Å) | Cite: | Crystal structure of FAS thioesterase domain with polyunsaturated fatty acyl adduct and inhibition by dihomo-gamma-linolenic acid. Proc.Natl.Acad.Sci.USA, 108, 2011
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4IAQ
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![BU of 4iaq by Molmil](/molmil-images/mine/4iaq) | Crystal structure of the chimeric protein of 5-HT1B-BRIL in complex with dihydroergotamine (PSI Community Target) | Descriptor: | Chimera protein of human 5-hydroxytryptamine receptor 1B and E. Coli soluble cytochrome b562, Dihydroergotamine | Authors: | Wang, C, Jiang, Y, Ma, J, Wu, H, Wacker, D, Katritch, V, Han, G.W, Liu, W, Huang, X, Vardy, E, McCorvy, J.D, Gao, X, Zhou, E.X, Melcher, K, Zhang, C, Bai, F, Yang, H, Yang, L, Jiang, H, Roth, B.L, Cherezov, V, Stevens, R.C, Xu, H.E, GPCR Network (GPCR) | Deposit date: | 2012-12-07 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural basis for molecular recognition at serotonin receptors. Science, 340, 2013
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3TLJ
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![BU of 3tlj by Molmil](/molmil-images/mine/3tlj) | Crystal structure of Trm14 from Pyrococcus furiosus in complex with S-adenosyl-L-homocysteine | Descriptor: | ACETATE ION, S-ADENOSYL-L-HOMOCYSTEINE, tRNA (guanine N2-)-methyltransferase Trm14 | Authors: | Fislage, M, Roovers, M, Tuszynska, I, Bujnicki, J.M, Droogmans, L, Versees, W. | Deposit date: | 2011-08-30 | Release date: | 2012-03-14 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. Nucleic Acids Res., 40, 2012
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3TM5
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![BU of 3tm5 by Molmil](/molmil-images/mine/3tm5) | Crystal structure of Trm14 from Pyrococcus furiosus in complex with sinefungin | Descriptor: | Crystal structure of Trm14, SINEFUNGIN | Authors: | Fislage, M, Roovers, M, Tuszynska, I, Bujnicki, J.M, Droogmans, L, Versees, W. | Deposit date: | 2011-08-31 | Release date: | 2012-03-14 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.27 Å) | Cite: | Crystal structures of the tRNA:m2G6 methyltransferase Trm14/TrmN from two domains of life. Nucleic Acids Res., 40, 2012
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4IB4
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![BU of 4ib4 by Molmil](/molmil-images/mine/4ib4) | Crystal structure of the chimeric protein of 5-HT2B-BRIL in complex with ergotamine | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CHOLESTEROL, ... | Authors: | Wacker, D, Wang, C, Katritch, V, Han, G.W, Huang, X, Vardy, E, McCorvy, J.D, Jiang, Y, Chu, M, Siu, F.Y, Liu, W, Xu, H.E, Cherezov, V, Roth, B.L, Stevens, R.C, GPCR Network (GPCR) | Deposit date: | 2012-12-07 | Release date: | 2013-03-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structural features for functional selectivity at serotonin receptors. Science, 340, 2013
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4I5G
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![BU of 4i5g by Molmil](/molmil-images/mine/4i5g) | Crystal structure of Ralstonia sp. alcohol dehydrogenase mutant N15G, G37D, R38V, R39S, A86N, S88A | Descriptor: | Alclohol dehydrogenase/short-chain dehydrogenase | Authors: | Jarasch, A, Lerchner, A, Meining, W, Schiefner, A, Skerra, A. | Deposit date: | 2012-11-28 | Release date: | 2013-06-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystallographic analysis and structure-guided engineering of NADPH-dependent Ralstonia sp. Alcohol dehydrogenase toward NADH cosubstrate specificity. Biotechnol.Bioeng., 110, 2013
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4JWV
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![BU of 4jwv by Molmil](/molmil-images/mine/4jwv) | Crystal Structure of putative short chain enoyl-CoA hydratase from Novosphingobium aromaticivorans DSM 12444 | Descriptor: | Short chain enoyl-CoA hydratase | Authors: | Cooper, D.R, Mikolajczak, K, Cymborowski, M, Grabowski, M, Ahmed, M, Stead, M, Hillerich, B, Seidel, R, Zimmerman, M, Bonanno, J.B, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-03-27 | Release date: | 2013-05-29 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal Structure of putative short chain enoyl-CoA hydratase from Novosphingobium aromaticivorans DSM 12444 To be Published
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3TI7
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![BU of 3ti7 by Molmil](/molmil-images/mine/3ti7) | |
4JXT
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![BU of 4jxt by Molmil](/molmil-images/mine/4jxt) | CID of human RPRD1A in complex with a phosphorylated peptide from RPB1-CTD | Descriptor: | DNA-directed RNA polymerase II subunit RPB1, Regulation of nuclear pre-mRNA domain-containing protein 1A, UNKNOWN ATOM OR ION | Authors: | Ni, Z, Xu, C, Tempel, W, El Bakkouri, M, Loppnau, P, Guo, X, Bountra, C, Weigelt, J, Arrowsmith, C.H, Edwards, A.M, Min, J, Greenblatt, J.F, Structural Genomics Consortium (SGC) | Deposit date: | 2013-03-28 | Release date: | 2013-11-13 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | RPRD1A and RPRD1B are human RNA polymerase II C-terminal domain scaffolds for Ser5 dephosphorylation. Nat.Struct.Mol.Biol., 21, 2014
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4J87
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![BU of 4j87 by Molmil](/molmil-images/mine/4j87) | Crystal structure of alpha-COP | Descriptor: | coatomer subunit alpha | Authors: | Ma, W, Goldberg, J. | Deposit date: | 2013-02-14 | Release date: | 2013-03-27 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Rules for the recognition of dilysine retrieval motifs by coatomer. Embo J., 32, 2013
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4J9S
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![BU of 4j9s by Molmil](/molmil-images/mine/4j9s) | Human DNA polymerase eta-DNA translocated binary complex: with TA base pair | Descriptor: | DNA (5'-D(*T*AP*TP*TP*TP*AP*TP*GP*AP*CP*GP*T)-3'), DNA (5'-D(*TP*AP*CP*GP*TP*CP*AP*TP*A)-3'), DNA polymerase eta, ... | Authors: | Zhao, Y, Gregory, M, Biertumpfel, C, Hua, Y, Hanaoka, F, Yang, W. | Deposit date: | 2013-02-16 | Release date: | 2013-05-01 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Mechanism of somatic hypermutation at the WA motif by human DNA polymerase eta. Proc.Natl.Acad.Sci.USA, 110, 2013
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4JA9
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![BU of 4ja9 by Molmil](/molmil-images/mine/4ja9) | Rat PP5 apo | Descriptor: | MAGNESIUM ION, Serine/threonine-protein phosphatase 5 | Authors: | Haslbeck, V, Helmuth, M, Alte, F, Popowicz, G, Schmidt, W, Weiwad, M, Fischer, G, Gemmecker, G, Sattler, M, Striggow, F, Groll, M, Richter, K. | Deposit date: | 2013-02-18 | Release date: | 2014-02-19 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Selective activators of protein phosphatase 5 target the auto-inhibitory mechanism. Biosci.Rep., 35, 2015
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3RBW
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![BU of 3rbw by Molmil](/molmil-images/mine/3rbw) | Crystal structure of Spire KIND domain | Descriptor: | Protein spire homolog 1 | Authors: | Vizcarra, C.L, Kreutz, B, Rodal, A.A, Toms, A.V, Lu, J, Zheng, W, Quinlan, M.E, Eck, M.J. | Deposit date: | 2011-03-30 | Release date: | 2011-07-06 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structure of the Spire KIND domain and insights into its interaction with Fmn-family formins Proc.Natl.Acad.Sci.USA, 2011
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4JXU
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![BU of 4jxu by Molmil](/molmil-images/mine/4jxu) | Structure of aminotransferase ilvE2 from Sinorhizobium meliloti complexed with PLP | Descriptor: | Putative aminotransferase | Authors: | Cooper, D.R, Cymborowski, M.T, Majorek, K.A, Niedzialkowska, E, Porebski, P.J, Stead, M, Hammonds, J, Seidel, R, Ahmed, M, Bonanno, J.B, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | Deposit date: | 2013-03-28 | Release date: | 2013-05-29 | Last modified: | 2022-04-13 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structure of aminotransferase ilvE2 from Sinorhizobium meliloti complexed with PLP To be Published
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