6CF8
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6CFC
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1TII
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1DP4
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![BU of 1dp4 by Molmil](/molmil-images/mine/1dp4) | DIMERIZED HORMONE BINDING DOMAIN OF THE ATRIAL NATRIURETIC PEPTIDE RECEPTOR | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ATRIAL NATRIURETIC PEPTIDE RECEPTOR A, ... | 著者 | van den Akker, F, Zhang, X, Miyagi, M, Huo, X, Misono, K.S, Yee, V.C. | 登録日 | 1999-12-23 | 公開日 | 2000-07-12 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the dimerized hormone-binding domain of a guanylyl-cyclase-coupled receptor. Nature, 406, 2000
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7UTB
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![BU of 7utb by Molmil](/molmil-images/mine/7utb) | KPC-2 CARBAPENEMASE IN COMPLEX WITH THE BORONIC ACID INHIBITOR MB_076 | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC, [(1~{R})-1-[2-[(5-azanyl-1,3,4-thiadiazol-2-yl)sulfanyl]ethanoylamino]-2-(4-carboxy-1,2,3-triazol-1-yl)ethyl]-$l^{3}-oxidanyl-bis(oxidanyl)boron | 著者 | van den Akker, F, Alsenani, T.A. | 登録日 | 2022-04-26 | 公開日 | 2022-12-14 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | Boronic Acid Transition State Inhibitors as Potent Inactivators of KPC and CTX-M beta-Lactamases: Biochemical and Structural Analyses. Antimicrob.Agents Chemother., 67, 2023
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6MPQ
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![BU of 6mpq by Molmil](/molmil-images/mine/6mpq) | 1.95 Ang crystal structure of OXA-24/40 beta-lactamase in complex the inhibitor ETX2514 | 分子名称: | (2S,5R)-1-formyl-3-methyl-5-[(sulfooxy)amino]-1,2,5,6-tetrahydropyridine-2-carboxamide, Beta-lactamase, CHLORIDE ION | 著者 | van den Akker, F, Kumar, V. | 登録日 | 2018-10-08 | 公開日 | 2019-02-27 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Targeting Multidrug-ResistantAcinetobacterspp.: Sulbactam and the Diazabicyclooctenone beta-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent. MBio, 10, 2019
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6PXX
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![BU of 6pxx by Molmil](/molmil-images/mine/6pxx) | Class D beta-lactamase in complex with beta-lactam antibiotic | 分子名称: | (2~{S},3~{R})-3-methyl-2-[(2~{S},3~{R})-3-oxidanyl-1-oxidanylidene-butan-2-yl]-4-[(3~{S},5~{S})-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-3,4-dihydro-2~{H}-pyrrole-5-carboxylic acid, 1,2-ETHANEDIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | 著者 | van den Akker, F, Kumar, V. | 登録日 | 2019-07-28 | 公開日 | 2019-10-09 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Analysis of The OXA-48 Carbapenemase Bound to A "Poor" Carbapenem Substrate, Doripenem. Antibiotics, 8, 2019
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7TB7
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![BU of 7tb7 by Molmil](/molmil-images/mine/7tb7) | Crystal structure of D179N KPC-2 beta-lactamase | 分子名称: | CITRIC ACID, Carbapenem-hydrolyzing beta-lactamase KPC | 著者 | van den Akker, F, Alsenani, T. | 登録日 | 2021-12-21 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (0.99 Å) | 主引用文献 | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66, 2022
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7TBX
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![BU of 7tbx by Molmil](/molmil-images/mine/7tbx) | Crystal structure of D179Y KPC-2 beta-lactamase | 分子名称: | Carbapenem-hydrolyzing beta-lactamase KPC | 著者 | van den Akker, F, Alsenani, T. | 登録日 | 2021-12-22 | 公開日 | 2022-03-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.16 Å) | 主引用文献 | Structural Characterization of the D179N and D179Y Variants of KPC-2 beta-Lactamase: Omega-Loop Destabilization as a Mechanism of Resistance to Ceftazidime-Avibactam. Antimicrob.Agents Chemother., 66, 2022
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7TC1
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8URN
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![BU of 8urn by Molmil](/molmil-images/mine/8urn) | Crystal structure of EscI(51-87)-linker-EtgA(18-152) fusion protein | 分子名称: | EscI inner rod protein type III secretion system,EtgA protein, SULFATE ION | 著者 | van den Akker, F. | 登録日 | 2023-10-26 | 公開日 | 2024-02-14 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structural insights into peptidoglycan glycosidase EtgA binding to the inner rod protein EscI of the type III secretion system via a designed EscI-EtgA fusion protein. Protein Sci., 33, 2024
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7LGK
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![BU of 7lgk by Molmil](/molmil-images/mine/7lgk) | Crystal structure of soluble guanylate cyclase activator runcaciguat (BAY 1101042) bound to nostoc H-NOX domain | 分子名称: | CHLORIDE ION, GLYCEROL, H-NOX domain protein, ... | 著者 | van den Akker, F, Kumar, V, Schaefer, M. | 登録日 | 2021-01-20 | 公開日 | 2021-05-05 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of the Soluble Guanylate Cyclase Activator Runcaciguat (BAY 1101042). J.Med.Chem., 64, 2021
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6B1X
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![BU of 6b1x by Molmil](/molmil-images/mine/6b1x) | Crystal structure KPC-2 beta-lactamase complexed with WCK 5153 by soaking | 分子名称: | (2S,5R)-1-formyl-N'-[(3R)-pyrrolidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, 1,2-ETHANEDIOL, CITRIC ACID, ... | 著者 | van den Akker, F, Nguyen, N.Q. | 登録日 | 2017-09-19 | 公開日 | 2018-08-01 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61, 2018
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6B1F
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![BU of 6b1f by Molmil](/molmil-images/mine/6b1f) | Crystal structure KPC-2 beta-lactamase complexed with WCK 4234 by soaking | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, 1,2-ETHANEDIOL, CITRIC ACID, ... | 著者 | van den Akker, F, Nguyen, N.Q. | 登録日 | 2017-09-18 | 公開日 | 2018-08-01 | 実験手法 | X-RAY DIFFRACTION (1.44 Å) | 主引用文献 | Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61, 2018
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6B1H
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![BU of 6b1h by Molmil](/molmil-images/mine/6b1h) | Crystal structure KPC-2 beta-lactamase complexed with WCK 4234 by co-crystallization | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, ACETATE ION, CHLORIDE ION, ... | 著者 | van den Akker, F, Nhuyen, N.Q. | 登録日 | 2017-09-18 | 公開日 | 2018-08-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61, 2018
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6B1J
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![BU of 6b1j by Molmil](/molmil-images/mine/6b1j) | Crystal structure KPC-2 beta-lactamase complexed with WCK 5107 by soaking | 分子名称: | (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, 1,2-ETHANEDIOL, CITRIC ACID, ... | 著者 | van den Akker, F, Nguyen, N.Q. | 登録日 | 2017-09-18 | 公開日 | 2018-08-01 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61, 2018
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6B1Y
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![BU of 6b1y by Molmil](/molmil-images/mine/6b1y) | Crystal structure KPC-2 beta-lactamase complexed with WCK 5153 by co-crystallization | 分子名称: | (2S,5Z)-1-formyl-5-imino-N'-[(3R)-1-(sulfooxy)pyrrolidine-3-carbonyl]piperidine-2-carbohydrazide, CHLORIDE ION, Carbapenem-hydrolyzing beta-lactamase KPC, ... | 著者 | van den Akker, F, Nguyen, N.Q. | 登録日 | 2017-09-19 | 公開日 | 2018-08-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61, 2018
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6B1W
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![BU of 6b1w by Molmil](/molmil-images/mine/6b1w) | Crystal structure KPC-2 beta-lactamase complexed with WCK 5107 by co-crystallization | 分子名称: | (2S,5R)-1-formyl-N'-[(3R)-piperidine-3-carbonyl]-5-[(sulfooxy)amino]piperidine-2-carbohydrazide, CHLORIDE ION, Carbapenem-hydrolyzing beta-lactamase KPC, ... | 著者 | van den Akker, F, Nguyen, N.Q. | 登録日 | 2017-09-19 | 公開日 | 2018-08-01 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61, 2018
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7LY1
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6B22
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![BU of 6b22 by Molmil](/molmil-images/mine/6b22) | Crystal structure OXA-24 beta-lactamase complexed with WCK 4234 by co-crystallization | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carbonitrile, Beta-lactamase, CHLORIDE ION | 著者 | van den Akker, F, Nguyen, N.Q. | 登録日 | 2017-09-19 | 公開日 | 2018-08-01 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Strategic Approaches to Overcome Resistance against Gram-Negative Pathogens Using beta-Lactamase Inhibitors and beta-Lactam Enhancers: Activity of Three Novel Diazabicyclooctanes WCK 5153, Zidebactam (WCK 5107), and WCK 4234. J. Med. Chem., 61, 2018
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6VOT
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![BU of 6vot by Molmil](/molmil-images/mine/6vot) | Crystal structure of Pseudomonas aerugonisa PBP3 complexed to gamma-lactam YU253434 | 分子名称: | 1-[(2S)-2-{[(2Z)-2-(2-amino-1,3-thiazol-4-yl)-2-{[(2-carboxypropan-2-yl)oxy]imino}acetyl]amino}-3-oxopropyl]-4-{[2-(5,6 -dihydroxy-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)ethyl]carbamoyl}-2,5-dihydro-1H-pyrazole-3-carboxylic acid, Peptidoglycan D,D-transpeptidase FtsI | 著者 | van den Akker, F. | 登録日 | 2020-01-31 | 公開日 | 2020-05-13 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | A gamma-Lactam Siderophore Antibiotic Effective against Multidrug-Resistant Gram-Negative Bacilli. J.Med.Chem., 63, 2020
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8GFF
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8GFE
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8GFG
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![BU of 8gfg by Molmil](/molmil-images/mine/8gfg) | Crystal structure of soluble lytic transglycosylase Cj0843 of Campylobacter jejuni in complex with Z7912 inhibitor | 分子名称: | (3S,3aR,5S,6S,6aS)-2-oxohexahydro-2H-3,5-methanocyclopenta[b]furan-6-yl 2-acetamido-2-deoxy-beta-D-glucopyranoside, CITRIC ACID, DIMETHYL SULFOXIDE, ... | 著者 | van den Akker, F, Kumar, V. | 登録日 | 2023-03-08 | 公開日 | 2023-05-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds. Protein Sci., 32, 2023
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8GFQ
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