5J0N
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5j0n by Molmil](/molmil-images/mine/5j0n) | Lambda excision HJ intermediate | Descriptor: | Excisionase, Integrase, Integration host factor subunit alpha, ... | Authors: | Van Duyne, G, Grigorieff, N, Landy, A. | Deposit date: | 2016-03-28 | Release date: | 2017-02-08 | Last modified: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (11 Å) | Cite: | Structure of a Holliday junction complex reveals mechanisms governing a highly regulated DNA transaction. Elife, 5, 2016
|
|
1FKB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1fkb by Molmil](/molmil-images/mine/1fkb) | ATOMIC STRUCTURE OF THE RAPAMYCIN HUMAN IMMUNOPHILIN FKBP-12 COMPLEX | Descriptor: | FK506 BINDING PROTEIN, RAPAMYCIN IMMUNOSUPPRESSANT DRUG | Authors: | Van Duyne, G.D, Standaert, R.F, Schreiber, S.L, Clardy, J.C. | Deposit date: | 1992-07-02 | Release date: | 1993-10-31 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Atomic Structure of the Rapamycin Human Immunophilin Fkbp-12 Complex J.Am.Chem.Soc., 113, 1991
|
|
1XXA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xxa by Molmil](/molmil-images/mine/1xxa) | C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX; PB DERIVATIVE | Descriptor: | ARGININE, ARGININE REPRESSOR, LEAD (II) ION | Authors: | Van Duyne, G.D, Ghosh, G, Maas, W.K, Sigler, P.B. | Deposit date: | 1995-11-03 | Release date: | 1996-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli. J.Mol.Biol., 256, 1996
|
|
1XXB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xxb by Molmil](/molmil-images/mine/1xxb) | C-TERMINAL DOMAIN OF ESCHERICHIA COLI ARGININE REPRESSOR/ L-ARGININE COMPLEX | Descriptor: | ARGININE, ARGININE REPRESSOR | Authors: | Van Duyne, G.D, Ghosh, G, Maas, W.K, Sigler, P.B. | Deposit date: | 1995-11-03 | Release date: | 1996-03-08 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure of the oligomerization and L-arginine binding domain of the arginine repressor of Escherichia coli. J.Mol.Biol., 256, 1996
|
|
1XXC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1xxc by Molmil](/molmil-images/mine/1xxc) | |
4OJR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4ojr by Molmil](/molmil-images/mine/4ojr) | Crystal Structure of the HIV-1 Integrase catalytic domain with GSK1264 | Descriptor: | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, CACODYLATE ION, HIV-1 Integrase, ... | Authors: | Gupta, K, Brady, T, Dyer, B, Hwang, Y, Male, F, Nolte, R.T, Wang, L, Velthuisen, E, Jeffrey, J, Van Duyne, G, Bushman, F.D. | Deposit date: | 2014-01-21 | Release date: | 2014-06-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.82 Å) | Cite: | Allosteric Inhibition of Human Immunodeficiency Virus Integrase: LATE BLOCK DURING VIRAL REPLICATION AND ABNORMAL MULTIMERIZATION INVOLVING SPECIFIC PROTEIN DOMAINS. J.Biol.Chem., 289, 2014
|
|
3BVP
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3bvp by Molmil](/molmil-images/mine/3bvp) | |
2LEH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 2leh by Molmil](/molmil-images/mine/2leh) | Solution structure of the core SMN-Gemin2 complex | Descriptor: | Survival motor neuron protein, Survival of motor neuron protein-interacting protein 1 | Authors: | Sarachan, K.L, Valentine, K, Gupta, K, Moorman, V, Gledhill, J, Bernens, M, Tommos, C, Wand, A.J, Van Duyne, G. | Deposit date: | 2011-06-15 | Release date: | 2012-06-27 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of the core SMN-Gemin2 complex. Biochem.J., 445, 2012
|
|
6VRG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6vrg by Molmil](/molmil-images/mine/6vrg) | Structure of HIV-1 integrase with native amino-terminal sequence | Descriptor: | Integrase, PHOSPHATE ION, POTASSIUM ION, ... | Authors: | Eilers, G, Gupta, K, Allen, A, Zhou, J, Hwang, Y, Cory, M, Bushman, F.D, Van Duyne, G.D. | Deposit date: | 2020-02-07 | Release date: | 2020-09-09 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Influence of the amino-terminal sequence on the structure and function of HIV integrase. Retrovirology, 17, 2020
|
|
8CTA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8cta by Molmil](/molmil-images/mine/8cta) | Minimal 2:2 Ternary Complex between BI-224436 bound HIV-1 Integrase Catalytic Core Domain Dimer and Carboxy Terminal Domains | Descriptor: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase | Authors: | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | Deposit date: | 2022-05-13 | Release date: | 2023-02-22 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.93 Å) | Cite: | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization. Plos Pathog., 19, 2023
|
|
8CT5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ct5 by Molmil](/molmil-images/mine/8ct5) | |
8CT7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8ct7 by Molmil](/molmil-images/mine/8ct7) | Catalytic Core Domain of HIV-1 Integrase (F185K) bound with BI-224436 | Descriptor: | (2S)-tert-butoxy[4-(2,3-dihydropyrano[4,3,2-de]quinolin-7-yl)-2-methylquinolin-3-yl]acetic acid, 1,2-ETHANEDIOL, Integrase, ... | Authors: | Gupta, K, Van Duyne, G.D, Eilers, G, Bushman, F.D. | Deposit date: | 2022-05-13 | Release date: | 2023-02-15 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Structure of a HIV-1 IN-Allosteric inhibitor complex at 2.93 angstrom resolution: Routes to inhibitor optimization. Plos Pathog., 19, 2023
|
|
5E6F
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5e6f by Molmil](/molmil-images/mine/5e6f) | Canarypox virus resolvase | Descriptor: | CNPV261 Holliday junction resolvase protein, D(-)-TARTARIC ACID, MAGNESIUM ION | Authors: | Li, H, Hwang, Y, Perry, K, Bushman, F.D, Van Duyne, G.D. | Deposit date: | 2015-10-09 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structure and Metal Binding Properties of a Poxvirus Resolvase. J.Biol.Chem., 291, 2016
|
|
6DNW
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dnw by Molmil](/molmil-images/mine/6dnw) | Sequence Requirements of the Listeria innocua prophage attP site | Descriptor: | DNA (26-MER), Putative integrase [Bacteriophage A118], ZINC ION | Authors: | Li, H, Sharp, R, Rutherford, K, Gupta, K, Van Duyne, G.D. | Deposit date: | 2018-06-08 | Release date: | 2018-10-03 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.849 Å) | Cite: | Serine Integrase attP Binding and Specificity. J. Mol. Biol., 430, 2018
|
|
5CRX
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5crx by Molmil](/molmil-images/mine/5crx) | |
5HOT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5hot by Molmil](/molmil-images/mine/5hot) | Structural Basis for Inhibitor-Induced Aggregation of HIV-1 Integrase | Descriptor: | (2S)-tert-butoxy[4-(8-fluoro-5-methyl-3,4-dihydro-2H-chromen-6-yl)-2-methyl-1-oxo-1,2-dihydroisoquinolin-3-yl]ethanoic acid, Integrase | Authors: | Gupta, K, Turkki, V, Sherrill-Mix, S, Hwang, Y, Eilers, G, Taylor, L, McDanal, C, Wang, P, Temelkoff, D, Nolte, R, Velthuisen, E, Jeffrey, J, Van Duyne, G.D, Bushman, F.D. | Deposit date: | 2016-01-19 | Release date: | 2016-12-14 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (4.4 Å) | Cite: | Structural Basis for Inhibitor-Induced Aggregation of HIV Integrase. PLoS Biol., 14, 2016
|
|
3C29
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3c29 by Molmil](/molmil-images/mine/3c29) | Cre-loxP Synaptic structure | Descriptor: | LoxP DNA, chain C,, chain D,F, ... | Authors: | Ghosh, K, Van Duyne, G.D. | Deposit date: | 2008-01-24 | Release date: | 2009-02-17 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Synapsis study in detail To be Published
|
|
3C28
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3c28 by Molmil](/molmil-images/mine/3c28) | |
1NFK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1nfk by Molmil](/molmil-images/mine/1nfk) | STRUCTURE OF THE NUCLEAR FACTOR KAPPA-B (NF-KB) P50 HOMODIMER | Descriptor: | DNA (5'-D(*TP*GP*GP*GP*AP*AP*TP*TP*CP*CP*C)-3'), PROTEIN (NUCLEAR FACTOR KAPPA-B (NF-KB)) | Authors: | Ghosh, G, Van Duyne, G, Ghosh, S, Sigler, P.B. | Deposit date: | 1995-02-28 | Release date: | 1996-12-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of NF-kappa B p50 homodimer bound to a kappa B site. Nature, 373, 1995
|
|
1P27
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1p27 by Molmil](/molmil-images/mine/1p27) | Crystal Structure of the Human Y14/Magoh complex | Descriptor: | Mago nashi protein homolog, RNA-binding protein 8A | Authors: | Lau, C.K, Diem, M.D, Dreyfuss, G, Van Duyne, G.D. | Deposit date: | 2003-04-14 | Release date: | 2003-08-19 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structure of the y14-magoh core of the exon junction complex. Curr.Biol., 13, 2003
|
|
1B4B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1b4b by Molmil](/molmil-images/mine/1b4b) | STRUCTURE OF THE OLIGOMERIZATION DOMAIN OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS | Descriptor: | ARGININE, ARGININE REPRESSOR | Authors: | Ni, J, Sakanyan, V, Charlier, D, Glansdorff, N, Van Duyne, G.D. | Deposit date: | 1998-12-18 | Release date: | 1999-06-15 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structure of the arginine repressor from Bacillus stearothermophilus. Nat.Struct.Biol., 6, 1999
|
|
1B4A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 1b4a by Molmil](/molmil-images/mine/1b4a) | STRUCTURE OF THE ARGININE REPRESSOR FROM BACILLUS STEAROTHERMOPHILUS | Descriptor: | ARGININE REPRESSOR | Authors: | Ni, J, Sakanyan, V, Charlier, D, Glansdorff, N, Van Duyne, G.D. | Deposit date: | 1998-12-18 | Release date: | 1999-06-15 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structure of the arginine repressor from Bacillus stearothermophilus. Nat.Struct.Biol., 6, 1999
|
|
5UDO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5udo by Molmil](/molmil-images/mine/5udo) | |
5U96
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5u96 by Molmil](/molmil-images/mine/5u96) | |
5UAE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5uae by Molmil](/molmil-images/mine/5uae) | Crystal structure of the coiled-coil domain from Listeria Innocua Phage Integrase (Trigonal Form) | Descriptor: | CITRATE ANION, Putative integrase | Authors: | Gupta, K, Sharp, R, Yuan, J.B, Van Duyne, G.D. | Deposit date: | 2016-12-19 | Release date: | 2017-05-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Coiled-coil interactions mediate serine integrase directionality. Nucleic Acids Res., 45, 2017
|
|