7ABG
 
 | | Human pre-Bact-1 spliceosome | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ... | | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | | 登録日 | 2020-09-07 | | 公開日 | 2020-12-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (7.8 Å) | | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
|
|
7ABI
 | | Human pre-Bact-2 spliceosome | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Beta-catenin-like protein 1, ... | | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | | 登録日 | 2020-09-07 | | 公開日 | 2021-02-10 | | 実験手法 | ELECTRON MICROSCOPY (8 Å) | | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
|
|
7ABF
 | | Human pre-Bact-1 spliceosome core structure | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... | | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | | 登録日 | 2020-09-07 | | 公開日 | 2020-12-09 | | 最終更新日 | 2020-12-30 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
|
|
7AAV
 | | Human pre-Bact-2 spliceosome core structure | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, Cell division cycle 5-like protein, D-chiro inositol hexakisphosphate, ... | | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | | 登録日 | 2020-09-04 | | 公開日 | 2020-12-09 | | 最終更新日 | 2020-12-30 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
|
|
7ABH
 | | Human pre-Bact-2 spliceosome (SF3b/U2 snRNP portion) | | 分子名称: | Cell division cycle 5-like protein, DNA/RNA-binding protein KIN17, MINX M3 pre-mRNA, ... | | 著者 | Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. | | 登録日 | 2020-09-07 | | 公開日 | 2020-12-09 | | 最終更新日 | 2024-05-01 | | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | | 主引用文献 | Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation.
Science, 370, 2020
|
|
1JGT
 | | CRYSTAL STRUCTURE OF BETA-LACTAM SYNTHETASE | | 分子名称: | BETA-LACTAM SYNTHETASE, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, GLYCEROL, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2001-06-26 | | 公開日 | 2001-12-28 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Structure of beta-lactam synthetase reveals how to synthesize antibiotics instead of asparagine.
Nat.Struct.Biol., 8, 2001
|
|
4IHE
 | |
5KBZ
 | | Structure of the PksA Product Template domain in complex with a phosphopantetheine mimetic | | 分子名称: | (14R)-14-hydroxy-15,15-dimethyl-1-[5-({[(5-methyl-1,2-oxazol-3-yl)methyl]sulfanyl}methyl)-1,2-oxazol-3-yl]-4,9,13-trioxo-2-thia-5,8,12-triazahexadecan-16-yl dihydrogen phosphate, Noranthrone synthase | | 著者 | Tsai, S.C, Burkart, M.D, Townsend, C.A, Barajas, J.F, Shakya, G, Topper, C.L, Moreno, G, Jackson, D.R, Rivera, H, La Clair, J.J, Vagstad, A. | | 登録日 | 2016-06-03 | | 公開日 | 2017-05-10 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.803 Å) | | 主引用文献 | Polyketide mimetics yield structural and mechanistic insights into product template domain function in nonreducing polyketide synthases.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
5MPT
 | | Structure of the citrinin polyketide synthase CMeT domain | | 分子名称: | 1,2-ETHANEDIOL, Citrinin polyketide synthase, S-ADENOSYL-L-HOMOCYSTEINE | | 著者 | Herbst, D.A, Storm, P.A, Townsend, C.A, Maier, T. | | 登録日 | 2016-12-19 | | 公開日 | 2017-02-22 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | | 主引用文献 | Functional and Structural Analysis of Programmed C-Methylation in the Biosynthesis of the Fungal Polyketide Citrinin.
Cell Chem Biol, 24, 2017
|
|
6FIK
 | | ACP2 crosslinked to the KS of the loading/condensing region of the CTB1 PKS | | 分子名称: | Polyketide synthase | | 著者 | Herbst, D.A, Huitt-Roehl, C.R, Jakob, R.P, Townsend, C.A, Maier, T. | | 登録日 | 2018-01-18 | | 公開日 | 2018-03-21 | | 最終更新日 | 2019-12-11 | | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | | 主引用文献 | The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
|
|
6FIJ
 | | Structure of the loading/condensing region (SAT-KS-MAT) of the cercosporin fungal non-reducing polyketide synthase (NR-PKS) CTB1 | | 分子名称: | 1,2-ETHANEDIOL, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, GLYCEROL, ... | | 著者 | Herbst, D.A, Jakob, R.P, Townsend, C.A, Maier, T. | | 登録日 | 2018-01-18 | | 公開日 | 2018-03-21 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.77 Å) | | 主引用文献 | The structural organization of substrate loading in iterative polyketide synthases.
Nat. Chem. Biol., 14, 2018
|
|
1MC1
 | | BETA-LACTAM SYNTHETASE WITH PRODUCT (DGPC), AMP AND PPI | | 分子名称: | ADENOSINE MONOPHOSPHATE, BETA-LACTAM SYNTHETASE, DEOXYGUANIDINOPROCLAVAMINIC ACID, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2002-08-04 | | 公開日 | 2002-10-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | | 主引用文献 | The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
|
|
1M1Z
 | |
1MB9
 | | BETA-LACTAM SYNTHETASE COMPLEXED WITH ATP | | 分子名称: | ADENOSINE MONOPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, BETA-LACTAM SYNTHETASE, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2002-08-02 | | 公開日 | 2002-10-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
|
|
1MBZ
 | | BETA-LACTAM SYNTHETASE WITH TRAPPED INTERMEDIATE | | 分子名称: | ARGININE-N-METHYLCARBONYL PHOSPHORIC ACID 5'-ADENOSINE ESTER, BETA-LACTAM SYNTHETASE, GLYCEROL, ... | | 著者 | Miller, M.T, Bachmann, B.O, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2002-08-04 | | 公開日 | 2002-10-23 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | | 主引用文献 | The catalytic cycle of beta -lactam synthetase observed by x-ray crystallographic snapshots
Proc.Natl.Acad.Sci.USA, 99, 2002
|
|
1Q15
 | | Carbapenam Synthetase | | 分子名称: | CarA | | 著者 | Miller, M.T, Gerratana, B, Stapon, A, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2003-07-18 | | 公開日 | 2003-11-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Carbapenam Synthetase (CarA)
J.Biol.Chem., 278, 2003
|
|
1Q19
 | | Carbapenam Synthetase | | 分子名称: | (2S,5S)-5-CARBOXYMETHYLPROLINE, CarA, DIPHOSPHOMETHYLPHOSPHONIC ACID ADENOSYL ESTER, ... | | 著者 | Miller, M.T, Gerratana, B, Stapon, A, Townsend, C.A, Rosenzweig, A.C. | | 登録日 | 2003-07-18 | | 公開日 | 2003-11-04 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal Structure of Carbapenam Synthetase (CarA)
J.Biol.Chem., 278, 2003
|
|
4IHD
 | |
