8DML
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![BU of 8dml by Molmil](/molmil-images/mine/8dml) | Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt chenodeoxycholate | Descriptor: | 1,2-ETHANEDIOL, CALCIUM ION, CHENODEOXYCHOLIC ACID, ... | Authors: | Tomchick, D.R, Orth, K, Zou, A.J. | Deposit date: | 2022-07-08 | Release date: | 2023-06-14 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Molecular determinants for differential activation of the bile acid receptor from the pathogen Vibrio parahaemolyticus. J.Biol.Chem., 299, 2023
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6E0B
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![BU of 6e0b by Molmil](/molmil-images/mine/6e0b) | Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 | Descriptor: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | Authors: | Tomchick, D.R, Phillips, M.A, Deng, X. | Deposit date: | 2018-07-06 | Release date: | 2018-11-14 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.099 Å) | Cite: | Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5, 2019
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6EAC
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![BU of 6eac by Molmil](/molmil-images/mine/6eac) | Pseudomonas syringae SelO | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CALCIUM ION, ... | Authors: | Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A. | Deposit date: | 2018-08-02 | Release date: | 2018-10-03 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.269 Å) | Cite: | Protein AMPylation by an Evolutionarily Conserved Pseudokinase. Cell, 175, 2018
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5EW4
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![BU of 5ew4 by Molmil](/molmil-images/mine/5ew4) | Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+ | Descriptor: | CHLORIDE ION, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R. | Deposit date: | 2015-11-20 | Release date: | 2016-02-24 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.47 Å) | Cite: | Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry, 55, 2016
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5EW7
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![BU of 5ew7 by Molmil](/molmil-images/mine/5ew7) | Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Ba2+ | Descriptor: | BARIUM ION, MAGNESIUM ION, POTASSIUM ION, ... | Authors: | Tomchick, D.R, Dodd, D.W, Gagnon, K.T, Corey, D.R. | Deposit date: | 2015-11-20 | Release date: | 2016-02-24 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches. Biochemistry, 55, 2016
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3U64
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![BU of 3u64 by Molmil](/molmil-images/mine/3u64) | The Crystal Structure of Tat-T (Tp0956) | Descriptor: | Protein TP_0956, SULFATE ION | Authors: | Tomchick, D.R, Brautigam, C.A, Deka, R.K, Norgard, M.V. | Deposit date: | 2011-10-12 | Release date: | 2012-02-22 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural, Bioinformatic, and In Vivo Analyses of Two Treponema pallidum Lipoproteins Reveal a Unique TRAP Transporter. J.Mol.Biol., 416, 2012
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3SWH
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![BU of 3swh by Molmil](/molmil-images/mine/3swh) | Munc13-1, MUN domain, C-terminal module | Descriptor: | Protein unc-13 homolog A | Authors: | Tomchick, D.R, Rizo, J, Li, W. | Deposit date: | 2011-07-13 | Release date: | 2011-11-02 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | The Crystal Structure of a Munc13 C-terminal Module Exhibits a Remarkable Similarity to Vesicle Tethering Factors. Structure, 19, 2011
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3V5Z
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![BU of 3v5z by Molmil](/molmil-images/mine/3v5z) | Structure of FBXL5 hemerythrin domain, C2 cell, grown anaerobically | Descriptor: | F-box/LRR-repeat protein 5, MU-OXO-DIIRON | Authors: | Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A. | Deposit date: | 2011-12-17 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1847 Å) | Cite: | Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5). J.Biol.Chem., 287, 2012
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3V5Y
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![BU of 3v5y by Molmil](/molmil-images/mine/3v5y) | Structure of FBXL5 hemerythrin domain, P2(1) cell | Descriptor: | F-box/LRR-repeat protein 5, MU-OXO-DIIRON | Authors: | Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A. | Deposit date: | 2011-12-17 | Release date: | 2012-01-25 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5). J.Biol.Chem., 287, 2012
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3V5X
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![BU of 3v5x by Molmil](/molmil-images/mine/3v5x) | Structure of FBXL5 hemerythrin domain, C2 cell | Descriptor: | F-box/LRR-repeat protein 5, MU-OXO-DIIRON | Authors: | Tomchick, D.R, Bruick, R.K, Thompson, J.W, Brautigam, C.A. | Deposit date: | 2011-12-17 | Release date: | 2012-01-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Structural and Molecular Characterization of Iron-sensing Hemerythrin-like Domain within F-box and Leucine-rich Repeat Protein 5 (FBXL5). J.Biol.Chem., 287, 2012
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4PKY
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![BU of 4pky by Molmil](/molmil-images/mine/4pky) | ARNT/HIF transcription factor/coactivator complex | Descriptor: | Aryl hydrocarbon receptor nuclear translocator, Endothelial PAS domain-containing protein 1, SULFATE ION, ... | Authors: | Tomchick, D.R, Partch, C.L, Gardner, K.H. | Deposit date: | 2014-05-15 | Release date: | 2015-02-11 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Coiled-coil Coactivators Play a Structural Role Mediating Interactions in Hypoxia-inducible Factor Heterodimerization. J.Biol.Chem., 290, 2015
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3L15
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![BU of 3l15 by Molmil](/molmil-images/mine/3l15) | Human Tead2 transcriptional factor | Descriptor: | GLYCEROL, Transcriptional enhancer factor TEF-4 | Authors: | Tomchick, D.R, Luo, X, Tian, W. | Deposit date: | 2009-12-10 | Release date: | 2010-04-07 | Last modified: | 2017-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural and functional analysis of the YAP-binding domain of human TEAD2. Proc.Natl.Acad.Sci.USA, 107, 2010
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3KY9
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![BU of 3ky9 by Molmil](/molmil-images/mine/3ky9) | Autoinhibited Vav1 | Descriptor: | Proto-oncogene vav, ZINC ION | Authors: | Tomchick, D.R, Rosen, M.K, Machius, M, Yu, B. | Deposit date: | 2009-12-04 | Release date: | 2010-02-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.731 Å) | Cite: | Structural and Energetic Mechanisms of Cooperative Autoinhibition and Activation of Vav1 Cell(Cambridge,Mass.), 140, 2010
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5JDA
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![BU of 5jda by Molmil](/molmil-images/mine/5jda) | Bacillus cereus CotH kinase plus Mg2+/AMP | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, ... | Authors: | Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A. | Deposit date: | 2016-04-15 | Release date: | 2016-05-18 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.401 Å) | Cite: | Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc.Natl.Acad.Sci.USA, 113, 2016
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5KEV
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5KEW
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![BU of 5kew by Molmil](/molmil-images/mine/5kew) | Vibrio parahaemolyticus VtrA/VtrC complex bound to the bile salt taurodeoxycholate | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, SULFATE ION, ... | Authors: | Tomchick, D.R, Orth, K, Rivera-Cancel, G. | Deposit date: | 2016-06-10 | Release date: | 2016-07-20 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.103 Å) | Cite: | Bile salt receptor complex activates a pathogenic type III secretion system. Elife, 5, 2016
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5JD9
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![BU of 5jd9 by Molmil](/molmil-images/mine/5jd9) | Bacillus cereus CotH kinase | Descriptor: | 1,2-ETHANEDIOL, MAGNESIUM ION, Spore coat protein H | Authors: | Tomchick, D.R, Tagliabracci, V.S, Sreelatha, A. | Deposit date: | 2016-04-15 | Release date: | 2016-05-18 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.63 Å) | Cite: | Phosphorylation of spore coat proteins by a family of atypical protein kinases. Proc.Natl.Acad.Sci.USA, 113, 2016
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6OQQ
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![BU of 6oqq by Molmil](/molmil-images/mine/6oqq) | Legionella pneumophila SidJ/Saccharomyces cerevisiae calmodulin complex | Descriptor: | 1,2-ETHANEDIOL, ADENOSINE MONOPHOSPHATE, CALCIUM ION, ... | Authors: | Tomchick, D.R, Tagliabracci, V.S, Black, M, Osinski, A. | Deposit date: | 2019-04-28 | Release date: | 2019-05-15 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.102 Å) | Cite: | Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases. Science, 364, 2019
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6PWD
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![BU of 6pwd by Molmil](/molmil-images/mine/6pwd) | Ewingella americana HopBF1 kinase | Descriptor: | 1,2-ETHANEDIOL, SULFATE ION, Type III effector HopBF1 | Authors: | Tomchick, D.R, Tagliabracci, V.S, Park, B.C. | Deposit date: | 2019-07-22 | Release date: | 2019-09-11 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.47 Å) | Cite: | A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity. Cell, 179, 2019
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6PWG
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![BU of 6pwg by Molmil](/molmil-images/mine/6pwg) | Ewingella americana HopBF1 kinase bound to AMP-PNP | Descriptor: | 1,2-ETHANEDIOL, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Type III effector HopBF1 | Authors: | Tomchick, D.R, Tagliabracci, V.S, Park, B.C. | Deposit date: | 2019-07-23 | Release date: | 2019-09-11 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | A Bacterial Effector Mimics a Host HSP90 Client to Undermine Immunity. Cell, 179, 2019
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9B8D
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![BU of 9b8d by Molmil](/molmil-images/mine/9b8d) | Structure of Legionella pneumophila Ceg10 | Descriptor: | 1,2-ETHANEDIOL, Ceg10, PHOSPHATE ION | Authors: | Tomchick, D.R, Heisler, D.B, Alto, N.M. | Deposit date: | 2024-03-29 | Release date: | 2024-04-10 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
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9B8E
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![BU of 9b8e by Molmil](/molmil-images/mine/9b8e) | Structure of S-nitrosylated Legionella pneumophila Ceg10. | Descriptor: | 1,2-ETHANEDIOL, ACETATE ION, CHLORIDE ION, ... | Authors: | Tomchick, D.R, Heisler, D.B, Alto, N.M. | Deposit date: | 2024-03-29 | Release date: | 2024-04-10 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Exploiting bacterial effector proteins to uncover evolutionarily conserved antiviral host machinery. Plos Pathog., 20, 2024
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4DBB
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![BU of 4dbb by Molmil](/molmil-images/mine/4dbb) | The PTB domain of Mint1 is autoinhibited by a helix in the C-terminal linker region | Descriptor: | ACETIC ACID, Amyloid beta A4 precursor protein-binding family A member 1, CHLORIDE ION, ... | Authors: | Tomchick, D.R, Rizo, J, Ho, A, Xu, Y. | Deposit date: | 2012-01-13 | Release date: | 2012-03-07 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Autoinhibition of Mint1 adaptor protein regulates amyloid precursor protein binding and processing. Proc.Natl.Acad.Sci.USA, 109, 2012
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4R39
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4R3A
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![BU of 4r3a by Molmil](/molmil-images/mine/4r3a) | Erythrobacter litoralis EL346 blue-light activated histidine kinase | Descriptor: | Blue-light-activated histidine kinase 2, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | Authors: | Tomchick, D.R, Rivera-Cancel, G, Gardner, K.H. | Deposit date: | 2014-08-14 | Release date: | 2014-12-03 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.92 Å) | Cite: | Full-length structure of a monomeric histidine kinase reveals basis for sensory regulation. Proc.Natl.Acad.Sci.USA, 111, 2014
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