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PDB: 28 results

8SGO
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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus pregnenolone sulfate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Legesse, D.H, Fan, C, Teng, J, Zhuang, Y, Howard, R.J, Noviello, C.M, Lindahl, E, Hibbs, R.E.
Deposit date:2023-04-12
Release date:2023-08-30
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.65 Å)
Cite:Structural insights into opposing actions of neurosteroids on GABA A receptors.
Nat Commun, 14, 2023
6PV8
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Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001
Descriptor: (3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gharpure, A, Teng, J, Zhuang, Y, Noviello, C.M, Walsh, R.M, Cabuco, R, Howard, R.J, Zaveri, N.T, Lindahl, E, Hibbs, R.E.
Deposit date:2019-07-19
Release date:2019-09-11
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.87 Å)
Cite:Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor.
Neuron, 104, 2019
6PV7
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Human alpha3beta4 nicotinic acetylcholine receptor in complex with nicotine
Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Gharpure, A, Teng, J, Zhuang, Y, Noviello, C.M, Walsh, R.M, Cabuco, R, Howard, R.J, Zaveri, N.T, Lindahl, E, Hibbs, R.E.
Deposit date:2019-07-19
Release date:2019-09-11
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3.34 Å)
Cite:Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor.
Neuron, 104, 2019
8VQY
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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus methaqualone
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-methyl-3-(2-methylphenyl)quinazolin-4(3H)-one, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Chojnacka, W, Teng, J, Kim, J.J, Jensen, A.A, Hibbs, R.E.
Deposit date:2024-01-19
Release date:2024-06-26
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.82 Å)
Cite:Structural insights into GABA A receptor potentiation by Quaalude.
Nat Commun, 15, 2024
8VRN
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BU of 8vrn by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus PPTQ
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3-(4-methylphenyl)-2-phenylquinazolin-4(3H)-one, ...
Authors:Chojnacka, W, Teng, J, Kim, J.J, Jensen, A.A, Hibbs, R.E.
Deposit date:2024-01-22
Release date:2024-06-26
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.57 Å)
Cite:Structural insights into GABA A receptor potentiation by Quaalude.
Nat Commun, 15, 2024
6D6U
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Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E.
Deposit date:2018-04-22
Release date:2018-06-27
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.92 Å)
Cite:Structure of a human synaptic GABAAreceptor.
Nature, 559, 2018
6D6T
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Human GABA-A receptor alpha1-beta2-gamma2 subtype in complex with GABA and flumazenil, conformation B
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Zhu, S, Noviello, C.M, Teng, J, Walsh Jr, R.M, Kim, J.J, Hibbs, R.E.
Deposit date:2018-04-22
Release date:2018-06-27
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (3.86 Å)
Cite:Structure of a human synaptic GABAAreceptor.
Nature, 559, 2018
6CNJ
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Structure of the 2alpha3beta stiochiometry of the human Alpha4Beta2 nicotinic receptor
Descriptor: (S)-3-(1-METHYLPYRROLIDIN-2-YL)PYRIDINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ...
Authors:Walsh Jr, R.M, Roh, S.H, Gharpure, A, Morales-Perez, C.L, Teng, J, Hibbs, R.E.
Deposit date:2018-03-08
Release date:2018-05-02
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Structural principles of distinct assemblies of the human alpha 4 beta 2 nicotinic receptor.
Nature, 557, 2018
6X3V
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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus etomidate
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Etomidate, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3W
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BU of 6x3w by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus phenobarbital
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 5-ethyl-5-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.3 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3U
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BU of 6x3u by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus flumazenil
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
8ESK
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BU of 8esk by Molmil
Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, resting-like state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E.
Deposit date:2022-10-14
Release date:2023-06-07
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.
Nat Commun, 14, 2023
8F2S
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BU of 8f2s by Molmil
Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with rocuronium, pore-blocked state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E.
Deposit date:2022-11-08
Release date:2023-06-07
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.
Nat Commun, 14, 2023
6X3S
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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with bicuculline methbromide
Descriptor: (5S)-6,6-dimethyl-5-[(6R)-8-oxo-6,8-dihydrofuro[3,4-e][1,3]benzodioxol-6-yl]-5,6,7,8-tetrahydro[1,3]dioxolo[4,5-g]isoquinolin-6-ium, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (3.12 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X40
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Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus picrotoxin
Descriptor: (1aR,2aR,3S,6R,6aS,8aS,8bR,9R)-2a-hydroxy-8b-methyl-9-(prop-1-en-2-yl)hexahydro-3,6-methano-1,5,7-trioxacyclopenta[ij]c yclopropa[a]azulene-4,8(3H)-dione, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3T
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BU of 6x3t by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus propofol
Descriptor: 2,6-BIS(1-METHYLETHYL)PHENOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (2.55 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3Z
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BU of 6x3z by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.23 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
6X3X
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BU of 6x3x by Molmil
Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA plus diazepam
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 7-CHLORO-1-METHYL-5-PHENYL-1,3-DIHYDRO-2H-1,4-BENZODIAZEPIN-2-ONE, ...
Authors:Kim, J.J, Gharpure, A, Teng, J, Zhuang, Y, Howard, R.J, Zhu, S, Noviello, C.M, Walsh, R.M, Lindahl, E, Hibbs, R.E.
Deposit date:2020-05-21
Release date:2020-09-09
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (2.92 Å)
Cite:Shared structural mechanisms of general anaesthetics and benzodiazepines.
Nature, 585, 2020
8F6Z
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BU of 8f6z by Molmil
Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with succinylcholine, desensitized-like state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2,2'-[(1,4-DIOXOBUTANE-1,4-DIYL)BIS(OXY)]BIS(N,N,N-TRIMETHYLETHANAMINIUM), 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E.
Deposit date:2022-11-17
Release date:2023-06-07
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (2.7 Å)
Cite:Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.
Nat Commun, 14, 2023
8F6Y
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BU of 8f6y by Molmil
Cryo-EM structure of Torpedo nicotinic acetylcholine receptor in complex with etomidate, desensitized-like state
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Goswami, U, Rahman, M.M, Teng, J, Hibbs, R.E.
Deposit date:2022-11-17
Release date:2023-06-07
Last modified:2024-11-13
Method:ELECTRON MICROSCOPY (2.79 Å)
Cite:Structural interplay of anesthetics and paralytics on muscle nicotinic receptors.
Nat Commun, 14, 2023
6UWZ
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BU of 6uwz by Molmil
Cryo-EM structure of Torpedo acetylcholine receptor in complex with alpha-bungarotoxin
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholine receptor subunit alpha, ...
Authors:Rahman, M.M, Teng, J, Worrell, B.T, Noveillo, C.M, Lee, M, Karlin, A, Stowell, M, Hibbs, R.E.
Deposit date:2019-11-06
Release date:2020-04-15
Last modified:2020-07-29
Method:ELECTRON MICROSCOPY (2.69 Å)
Cite:Structure of the Native Muscle-type Nicotinic Receptor and Inhibition by Snake Venom Toxins.
Neuron, 106, 2020
7T0Z
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BU of 7t0z by Molmil
Complex of GABA-A synaptic receptor with autoimmune antibody Fab175
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab175 IgG1 heavy chain, ...
Authors:Noviello, C.M, Hibbs, R.E, Kreye, J, Teng, J, Pruss, H.
Deposit date:2021-11-30
Release date:2022-07-13
Last modified:2024-11-20
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mechanisms of GABA A receptor autoimmune encephalitis.
Cell, 185, 2022
7T0W
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BU of 7t0w by Molmil
Complex of GABA-A synaptic receptor with autoimmune antibody Fab115
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab115 Heavy Chain, IgG1, ...
Authors:Noviello, C.M, Hibbs, R.E, Kreye, J, Teng, J, Pruss, H.
Deposit date:2021-11-30
Release date:2022-07-13
Last modified:2024-10-23
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Structural mechanisms of GABA A receptor autoimmune encephalitis.
Cell, 185, 2022
7SMM
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BU of 7smm by Molmil
Cryo-EM structure of Torpedo acetylcholine receptor in apo form
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Rahman, M.M, Basta, T, Teng, J, Lee, M, Worrell, B.T, Stowell, M.H.B, Hibbs, R.E.
Deposit date:2021-10-26
Release date:2022-03-09
Last modified:2024-11-06
Method:ELECTRON MICROSCOPY (2.5 Å)
Cite:Structural mechanism of muscle nicotinic receptor desensitization and block by curare.
Nat.Struct.Mol.Biol., 29, 2022
7SMQ
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BU of 7smq by Molmil
Cryo-EM structure of Torpedo acetylcholine receptor in apo form with added cholesterol
Descriptor: (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
Authors:Rahman, M.M, Basta, T, Teng, J, Lee, M, Worrell, B.T, Stowell, M.H.B, Hibbs, R.E.
Deposit date:2021-10-26
Release date:2022-03-09
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (2.74 Å)
Cite:Structural mechanism of muscle nicotinic receptor desensitization and block by curare.
Nat.Struct.Mol.Biol., 29, 2022

 

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