6PV8

Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001

Summary for 6PV8

Entry DOI	10.2210/pdb6pv8/pdb
EMDB information	20488
Descriptor	Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562, 2-acetamido-2-deoxy-beta-D-glucopyranose, SODIUM ION, ... (12 entities in total)
Functional Keywords	ligand-gated ion channel, nicotinic acetylcholine receptor, cys-loop receptor, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	9
Total formula weight	411781.86
Authors	Gharpure, A.,Teng, J.,Zhuang, Y.,Noviello, C.M.,Walsh, R.M.,Cabuco, R.,Howard, R.J.,Zaveri, N.T.,Lindahl, E.,Hibbs, R.E. (deposition date: 2019-07-19, release date: 2019-09-11, Last modification date: 2020-07-29)
Primary citation	Gharpure, A.,Teng, J.,Zhuang, Y.,Noviello, C.M.,Walsh Jr., R.M.,Cabuco, R.,Howard, R.J.,Zaveri, N.T.,Lindahl, E.,Hibbs, R.E. Agonist Selectivity and Ion Permeation in the alpha 3 beta 4 Ganglionic Nicotinic Receptor. Neuron, 104:501-, 2019 Cited by PubMed: 31488329 DOI: 10.1016/j.neuron.2019.07.030 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.87 Å)

Structure validation