Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

6PV8

Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004888	molecular_function	transmembrane signaling receptor activity
A	0005216	molecular_function	monoatomic ion channel activity
A	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
A	0005506	molecular_function	iron ion binding
A	0006811	biological_process	monoatomic ion transport
A	0009055	molecular_function	electron transfer activity
A	0016020	cellular_component	membrane
A	0020037	molecular_function	heme binding
A	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
A	0022900	biological_process	electron transport chain
A	0034220	biological_process	monoatomic ion transmembrane transport
A	0042597	cellular_component	periplasmic space
A	0045211	cellular_component	postsynaptic membrane
B	0004888	molecular_function	transmembrane signaling receptor activity
B	0005216	molecular_function	monoatomic ion channel activity
B	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
B	0005506	molecular_function	iron ion binding
B	0006811	biological_process	monoatomic ion transport
B	0009055	molecular_function	electron transfer activity
B	0016020	cellular_component	membrane
B	0020037	molecular_function	heme binding
B	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
B	0022900	biological_process	electron transport chain
B	0034220	biological_process	monoatomic ion transmembrane transport
B	0042597	cellular_component	periplasmic space
B	0045211	cellular_component	postsynaptic membrane
C	0004888	molecular_function	transmembrane signaling receptor activity
C	0005216	molecular_function	monoatomic ion channel activity
C	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
C	0005506	molecular_function	iron ion binding
C	0006811	biological_process	monoatomic ion transport
C	0009055	molecular_function	electron transfer activity
C	0016020	cellular_component	membrane
C	0020037	molecular_function	heme binding
C	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
C	0022900	biological_process	electron transport chain
C	0034220	biological_process	monoatomic ion transmembrane transport
C	0042597	cellular_component	periplasmic space
C	0045211	cellular_component	postsynaptic membrane
D	0004888	molecular_function	transmembrane signaling receptor activity
D	0005216	molecular_function	monoatomic ion channel activity
D	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
D	0005506	molecular_function	iron ion binding
D	0006811	biological_process	monoatomic ion transport
D	0009055	molecular_function	electron transfer activity
D	0016020	cellular_component	membrane
D	0020037	molecular_function	heme binding
D	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
D	0022900	biological_process	electron transport chain
D	0034220	biological_process	monoatomic ion transmembrane transport
D	0042597	cellular_component	periplasmic space
D	0045211	cellular_component	postsynaptic membrane
E	0004888	molecular_function	transmembrane signaling receptor activity
E	0005216	molecular_function	monoatomic ion channel activity
E	0005230	molecular_function	extracellular ligand-gated monoatomic ion channel activity
E	0005506	molecular_function	iron ion binding
E	0006811	biological_process	monoatomic ion transport
E	0009055	molecular_function	electron transfer activity
E	0016020	cellular_component	membrane
E	0020037	molecular_function	heme binding
E	0022848	molecular_function	acetylcholine-gated monoatomic cation-selective channel activity
E	0022900	biological_process	electron transport chain
E	0034220	biological_process	monoatomic ion transmembrane transport
E	0042597	cellular_component	periplasmic space
E	0045211	cellular_component	postsynaptic membrane

Functional Information from PROSITE/UniProt

site_id	PS00236
Number of Residues	15
Details	NEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CkIeVkyFPfDqqnC

Chain	Residue	Details
B	CYS132-CYS146
A	CYS128-CYS142

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH

Chain	Residue	Details
G	TYR213-HIS219

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	723
Details	TOPO_DOM: Extracellular => ECO:0000255

Chain	Residue	Details
B	ARG1-THR215
B	PRO266-TYR277
B	LEU461-ASP477
C	ARG1-THR215
C	PRO266-TYR277
C	LEU461-ASP477
E	ARG1-THR215
E	PRO266-TYR277
E	LEU461-ASP477

site_id	SWS_FT_FI2
Number of Residues	240
Details	TRANSMEM: Helical => ECO:0000255

Chain	Residue	Details
B	ILE216-PRO236
E	LEU245-PRO265
E	LEU278-VAL298
E	LEU440-PRO460
B	LEU245-PRO265
B	LEU278-VAL298
B	LEU440-PRO460
C	ILE216-PRO236
C	LEU245-PRO265
C	LEU278-VAL298
C	LEU440-PRO460
E	ILE216-PRO236

site_id	SWS_FT_FI3
Number of Residues	21
Details	TOPO_DOM: Cytoplasmic => ECO:0000255

Chain	Residue	Details
B	SER237-THR244
C	SER237-THR244
E	SER237-THR244
D	ALA331

site_id	SWS_FT_FI4
Number of Residues	3
Details	SITE: Key residue that facilitates effective access of the conotoxin BuIA to the channel binding site => ECO:0000250\|UniProtKB:P12392

Chain	Residue	Details
B	LYS61
C	LYS61
E	LYS61
D	ASN141

site_id	SWS_FT_FI5
Number of Residues	3
Details	SITE: Key residue for a low dissociation (K(off)) from the conotoxin BuIA => ECO:0000250\|UniProtKB:P12392

Chain	Residue	Details
B	ILE113
C	ILE113
E	ILE113

site_id	SWS_FT_FI6
Number of Residues	12
Details	CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255

Chain	Residue	Details
B	ASN15
E	ASN72
E	ASN117
E	ASN145
B	ASN72
B	ASN117
B	ASN145
C	ASN15
C	ASN72
C	ASN117
C	ASN145
E	ASN15

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)