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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6PV8

Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001

Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0005506molecular_functioniron ion binding
A0006811biological_processmonoatomic ion transport
A0009055molecular_functionelectron transfer activity
A0016020cellular_componentmembrane
A0020037molecular_functionheme binding
A0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
A0022900biological_processelectron transport chain
A0034220biological_processmonoatomic ion transmembrane transport
A0042597cellular_componentperiplasmic space
A0045211cellular_componentpostsynaptic membrane
B0004888molecular_functiontransmembrane signaling receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0005506molecular_functioniron ion binding
B0006811biological_processmonoatomic ion transport
B0009055molecular_functionelectron transfer activity
B0016020cellular_componentmembrane
B0020037molecular_functionheme binding
B0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
B0022900biological_processelectron transport chain
B0034220biological_processmonoatomic ion transmembrane transport
B0042597cellular_componentperiplasmic space
B0045211cellular_componentpostsynaptic membrane
C0004888molecular_functiontransmembrane signaling receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0005506molecular_functioniron ion binding
C0006811biological_processmonoatomic ion transport
C0009055molecular_functionelectron transfer activity
C0016020cellular_componentmembrane
C0020037molecular_functionheme binding
C0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
C0022900biological_processelectron transport chain
C0034220biological_processmonoatomic ion transmembrane transport
C0042597cellular_componentperiplasmic space
C0045211cellular_componentpostsynaptic membrane
D0004888molecular_functiontransmembrane signaling receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0005506molecular_functioniron ion binding
D0006811biological_processmonoatomic ion transport
D0009055molecular_functionelectron transfer activity
D0016020cellular_componentmembrane
D0020037molecular_functionheme binding
D0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
D0022900biological_processelectron transport chain
D0034220biological_processmonoatomic ion transmembrane transport
D0042597cellular_componentperiplasmic space
D0045211cellular_componentpostsynaptic membrane
E0004888molecular_functiontransmembrane signaling receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0005506molecular_functioniron ion binding
E0006811biological_processmonoatomic ion transport
E0009055molecular_functionelectron transfer activity
E0016020cellular_componentmembrane
E0020037molecular_functionheme binding
E0022848molecular_functionacetylcholine-gated monoatomic cation-selective channel activity
E0022900biological_processelectron transport chain
E0034220biological_processmonoatomic ion transmembrane transport
E0042597cellular_componentperiplasmic space
E0045211cellular_componentpostsynaptic membrane
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CkIdVtyFPfDyqnC
ChainResidueDetails
ACYS128-CYS142
BCYS132-CYS146
site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YTCEATH
ChainResidueDetails
GTYR213-HIS219
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues478
DetailsTopological domain: {"description":"Extracellular","evidences":[{"source":"PubMed","id":"31488329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues134
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31488329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues2
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"source":"PubMed","id":"31488329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PV7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues16
DetailsGlycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues488
DetailsTopological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues231
DetailsTransmembrane: {"description":"Helical","evidences":[{"source":"PubMed","id":"31488329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PV7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6PV8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI7
Number of Residues15
DetailsTopological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI8
Number of Residues3
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"31488329","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"6PV8","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI9
Number of Residues3
DetailsSite: {"description":"Key residue that facilitates effective access of the conotoxin BuIA to the channel binding site","evidences":[{"source":"UniProtKB","id":"P12392","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails
site_idSWS_FT_FI10
Number of Residues3
DetailsSite: {"description":"Key residue for a low dissociation (K(off)) from the conotoxin BuIA","evidences":[{"source":"UniProtKB","id":"P12392","evidenceCode":"ECO:0000250"}]}
ChainResidueDetails

239492

PDB entries from 2025-07-30

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