6PV8
Human alpha3beta4 nicotinic acetylcholine receptor in complex with AT-1001
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Fusion protein of Neuronal acetylcholine receptor subunit alpha-3 and Soluble cytochrome b562 | polymer | 525 | 60087.4 | 2 | UniProt (P32297) UniProt (A0A3W4NZ06) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | |
2 | B, C, E | Fusion protein of Neuronal acetylcholine receptor subunit beta-4 and Soluble cytochrome b562 | polymer | 538 | 61337.6 | 3 | UniProt (P30926) UniProt (A0A3W4NZ06) Pfam (PF02931) Pfam (PF02932) In PDB | Homo sapiens (Human) | |
3 | F, H | IgG2b Fab heavy chain | polymer | 219 | 23396.1 | 2 | Mus musculus (house mouse) | ||
4 | G, I | Kappa Fab light chain | polymer | 213 | 23401.9 | 2 | Mus musculus (house mouse) | ||
5 | J, P | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
6 | K, M, O, Q, S | alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 910.8 | 5 | In PDB GlyTouCan (G22768VO) | |||
7 | L, N, R | beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 586.5 | 3 | In PDB GlyTouCan (G15407YE) | |||
8 | D, A | (3-endo)-N-(2-bromophenyl)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine | non-polymer | 309.2 | 2 | Chemie (P1M) | |||
9 | C, D, E, A, B | CHOLESTEROL HEMISUCCINATE | non-polymer | 486.7 | 10 | Chemie (Y01) | |||
10 | C, E, B | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 6 | Chemie (NAG) | |||
11 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
12 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A, D: 1 - 327 (UniProt: P32297)
A, D: 327 - 331 (UniProt: A0A3W4NZ06)
A, D: 331 - 474 (UniProt: P32297)
B, C, E: 1 - 328 (UniProt: P30926)
B, C, E: 328 - 332 (UniProt: A0A3W4NZ06)
B, C, E: 332 - 477 (UniProt: P30926)
A, D: 327 - 331 (UniProt: A0A3W4NZ06)
PDB | External Database | Details |
---|---|---|
Trp 328 | Met 29 | conflict |
Ile 331 | His 124 | conflict |
Leu 331 | - | linker |
B, C, E: 1 - 328 (UniProt: P30926)
B, C, E: 328 - 332 (UniProt: A0A3W4NZ06)
PDB | External Database | Details |
---|---|---|
Trp 328 | Met 29 | conflict |
Ile 332 | His 124 | conflict |
Leu 332 | - | linker |
PDB | External Database | Details |
---|---|---|
Ser 478 | - | expression tag |
Ala 479 | - | expression tag |
Trp 480 | - | expression tag |
Ser 481 | - | expression tag |
His 482 | - | expression tag |
Pro 483 | - | expression tag |
Gln 484 | - | expression tag |
Phe 485 | - | expression tag |
Glu 486 | - | expression tag |
Lys 487 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 9 |
Total formula weight | 397783.3 | |
Branched | Number of molecules | 10 |
Total formula weight | 7162.5 | |
Non-Polymers* | Number of molecules | 19 |
Total formula weight | 6836.0 | |
All* | Total formula weight | 411781.9 |