6X3Z

Human GABAA receptor alpha1-beta2-gamma2 subtype in complex with GABA

Summary for 6X3Z

Entry DOI	10.2210/pdb6x3z/pdb
EMDB information	22037
Descriptor	Gamma-aminobutyric acid receptor subunit beta-2, GAMMA-AMINO-BUTANOIC ACID, Gamma-aminobutyric acid receptor subunit alpha-1, ... (10 entities in total)
Functional Keywords	ion channel, cys-loop receptor, pentametic ligand gated ion channel, gabaa receptor, membrane protein
Biological source	Homo sapiens (Human) More
Total number of polymer chains	9
Total formula weight	364238.55
Authors	Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh, R.M.,Lindahl, E.,Hibbs, R.E. (deposition date: 2020-05-21, release date: 2020-09-09, Last modification date: 2023-11-15)
Primary citation	Kim, J.J.,Gharpure, A.,Teng, J.,Zhuang, Y.,Howard, R.J.,Zhu, S.,Noviello, C.M.,Walsh Jr., R.M.,Lindahl, E.,Hibbs, R.E. Shared structural mechanisms of general anaesthetics and benzodiazepines. Nature, 585:303-308, 2020 Cited by PubMed: 32879488 DOI: 10.1038/s41586-020-2654-5 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.23 Å)

Structure validation