7T0W

Complex of GABA-A synaptic receptor with autoimmune antibody Fab115

This is a non-PDB format compatible entry.

Summary for 7T0W

• Entry DOI: 10.2210/pdb7t0w/pdb
• EMDB information: 25583 25585
• Descriptor: Gamma-aminobutyric acid receptor subunit beta-2, Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit gamma-2, ... (8 entities in total)
• Functional Keywords: autoimmunity, encephalitis, gaba, inhibitory, membrane protein-immune system complex, membrane protein/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 9
• Total formula weight: 307353.23

Authors

Noviello, C.M.,Hibbs, R.E.,Kreye, J.,Teng, J.,Pruss, H. (deposition date: 2021-11-30, release date: 2022-07-13, Last modification date: 2022-07-20)

• Primary citation: Noviello, C.M.,Kreye, J.,Teng, J.,Pruss, H.,Hibbs, R.E.; Structural mechanisms of GABA A receptor autoimmune encephalitis.; Cell, 185:2469-, 2022; PubMed: 35803245; DOI: 10.1016/j.cell.2022.06.025

Experimental method

ELECTRON MICROSCOPY (3 Å)