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7T0W

Complex of GABA-A synaptic receptor with autoimmune antibody Fab115

This is a non-PDB format compatible entry.
Functional Information from GO Data
ChainGOidnamespacecontents
A0004888molecular_functiontransmembrane signaling receptor activity
A0004890molecular_functionGABA-A receptor activity
A0005216molecular_functionmonoatomic ion channel activity
A0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
A0006811biological_processmonoatomic ion transport
A0016020cellular_componentmembrane
A0034220biological_processmonoatomic ion transmembrane transport
B0004888molecular_functiontransmembrane signaling receptor activity
B0004890molecular_functionGABA-A receptor activity
B0005216molecular_functionmonoatomic ion channel activity
B0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
B0006811biological_processmonoatomic ion transport
B0016020cellular_componentmembrane
B0034220biological_processmonoatomic ion transmembrane transport
C0004888molecular_functiontransmembrane signaling receptor activity
C0004890molecular_functionGABA-A receptor activity
C0005216molecular_functionmonoatomic ion channel activity
C0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
C0006811biological_processmonoatomic ion transport
C0016020cellular_componentmembrane
C0034220biological_processmonoatomic ion transmembrane transport
D0004888molecular_functiontransmembrane signaling receptor activity
D0004890molecular_functionGABA-A receptor activity
D0005216molecular_functionmonoatomic ion channel activity
D0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
D0006811biological_processmonoatomic ion transport
D0016020cellular_componentmembrane
D0034220biological_processmonoatomic ion transmembrane transport
E0004888molecular_functiontransmembrane signaling receptor activity
E0004890molecular_functionGABA-A receptor activity
E0005216molecular_functionmonoatomic ion channel activity
E0005230molecular_functionextracellular ligand-gated monoatomic ion channel activity
E0006811biological_processmonoatomic ion transport
E0006821biological_processchloride transport
E0007214biological_processgamma-aminobutyric acid signaling pathway
E0016020cellular_componentmembrane
E0034220biological_processmonoatomic ion transmembrane transport
Functional Information from PROSITE/UniProt
site_idPS00236
Number of Residues15
DetailsNEUROTR_ION_CHANNEL Neurotransmitter-gated ion-channels signature. CqLqLhnFPmDehsC
ChainResidueDetails
ECYS151-CYS165
ACYS136-CYS150
BCYS139-CYS153

site_idPS00290
Number of Residues7
DetailsIG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YICNVNH
ChainResidueDetails
HTYR206-HIS212
L2TYR196-HIS202

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues246
DetailsTOPO_DOM: Extracellular => ECO:0000305
ChainResidueDetails
EGLN1-PHE236
EARG284-ALA295
DGLN1-PHE226
DASN275-THR284

site_idSWS_FT_FI2
Number of Residues63
DetailsTRANSMEM: Helical => ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6I53
ChainResidueDetails
ETHR237-ILE257
EALA264-ALA283
EMET296-PHE320
BLEU324-THR343
DVAL227-LEU247
DPRO253-ARG274
DALA285-THR306
DLEU324-THR343

site_idSWS_FT_FI3
Number of Residues5
DetailsTOPO_DOM: Cytoplasmic => ECO:0000305
ChainResidueDetails
EASN258-PRO263
DASN248-VAL252

site_idSWS_FT_FI4
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
EASN13
EASN90
ATHR202
CTYR97
CSER156
CTHR202

site_idSWS_FT_FI5
Number of Residues1
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6I53
ChainResidueDetails
EASN208
DTHR130

site_idSWS_FT_FI6
Number of Residues2
DetailsBINDING: BINDING => ECO:0000269|PubMed:30266951
ChainResidueDetails
BTRP246
DTRP246

site_idSWS_FT_FI7
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255
ChainResidueDetails
BASN11
DASN11
CASN80
CASN149

site_idSWS_FT_FI8
Number of Residues2
DetailsCARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:29950725, ECO:0000269|PubMed:30602789, ECO:0007744|PDB:6D6T, ECO:0007744|PDB:6D6U, ECO:0007744|PDB:6I53
ChainResidueDetails
BASN111
DASN111

229183

PDB entries from 2024-12-18

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