1LCD
 
 | | STRUCTURE OF THE COMPLEX OF LAC REPRESSOR HEADPIECE AND AN 11 BASE-PAIR HALF-OPERATOR DETERMINED BY NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY AND RESTRAINED MOLECULAR DYNAMICS | | 分子名称: | DNA (5'-D(*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*G)-3'), DNA (5'-D(*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*T)-3'), Lac Repressor, ... | | 著者 | Chuprina, V.P, Rullmann, J.A.C, Lamerichs, R.M.J.N, Van Boom, J.H, Boelens, R, Kaptein, R. | | 登録日 | 1993-03-25 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of the complex of lac repressor headpiece and an 11 base-pair half-operator determined by nuclear magnetic resonance spectroscopy and restrained molecular dynamics.
J.Mol.Biol., 234, 1993
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4E26
 | | BRAF in complex with an organic inhibitor 7898734 | | 分子名称: | 5-chloro-7-[(R)-furan-2-yl(pyridin-2-ylamino)methyl]quinolin-8-ol, Serine/threonine-protein kinase B-raf | | 著者 | Qin, J, Xie, P, Ventocilla, C, Zhou, G, Vultur, A, Chen, Q, Herlyn, M, Winkler, J, Marmorstein, R. | | 登録日 | 2012-03-07 | | 公開日 | 2012-05-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | | 主引用文献 | Identification of a Novel Family of BRAF(V600E) Inhibitors.
J.Med.Chem., 55, 2012
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2LYH
 | | Structure of Faap24 residues 141-215 | | 分子名称: | Fanconi anemia-associated protein of 24 kDa | | 著者 | Wienk, H, Slootweg, J, Kaptein, R, Boelens, R, Folkers, G.E. | | 登録日 | 2012-09-18 | | 公開日 | 2013-05-01 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition.
Nucleic Acids Res., 41, 2013
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3T0O
 | | Crystal Structure Analysis of Human RNase T2 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Ribonuclease T2 | | 著者 | Thorn, A, Kraetzner, R, Steinfeld, R, Sheldrick, G. | | 登録日 | 2011-07-20 | | 公開日 | 2012-07-11 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | | 主引用文献 | Structure and activity of the only human RNase T2.
Nucleic Acids Res., 40, 2012
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1TYO
 | | Isocitrate Dehydrogenase from the hyperthermophile Aeropyrum pernix in complex with etheno-NADP | | 分子名称: | ETHENO-NADP, isocitrate dehydrogenase | | 著者 | Karlstrom, M, Stokke, R, Steen, I.H, Birkeland, N, Ladenstein, R. | | 登録日 | 2004-07-08 | | 公開日 | 2005-07-08 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Isocitrate dehydrogenase from the hyperthermophile Aeropyrum pernix: X-ray structure analysis of a ternary enzyme-substrate complex and thermal stability
J.Mol.Biol., 345, 2005
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2VKC
 | | Solution structure of the B3BP Smr domain | | 分子名称: | NEDD4-BINDING PROTEIN 2 | | 著者 | Diercks, T, Ab, E, Daniels, M.A, deJong, R.N, Besseling, R, Kaptein, R, Folkers, G.E. | | 登録日 | 2007-12-18 | | 公開日 | 2008-10-14 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Solution Structure and Characterization of the DNA- Binding Activity of the B3BP-Smr Domain.
J.Mol.Biol., 383, 2008
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7SNI
 | | Structure of G6PD-D200N tetramer bound to NADP+ and G6P | | 分子名称: | 6-O-phosphono-beta-D-glucopyranose, Glucose-6-phosphate 1-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Wei, X, Marmorstein, R. | | 登録日 | 2021-10-28 | | 公開日 | 2022-07-13 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | | 主引用文献 | Allosteric role of a structural NADP + molecule in glucose-6-phosphate dehydrogenase activity.
Proc.Natl.Acad.Sci.USA, 119, 2022
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3IR8
 | | Red fluorescent protein mKeima at pH 7.0 | | 分子名称: | Large stokes shift fluorescent protein | | 著者 | Henderson, J.N, Osborn, M.F, Koon, N, Gepshtein, R, Huppert, D, Remington, S.J. | | 登録日 | 2009-08-21 | | 公開日 | 2009-09-08 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | | 主引用文献 | Excited state proton transfer in the red fluorescent protein mKeima.
J.Am.Chem.Soc., 131, 2009
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2BJC
 | | NMR structure of a protein-DNA complex of an altered specificity mutant of the lac repressor headpiece that mimics the gal repressor | | 分子名称: | 5'-D(*GP*AP*AP*TP*TP*GP*TP*AP*AP*GP *CP*GP*CP*TP*TP*AP*CP*AP*AP*TP*TP*C)-3', LACTOSE OPERON REPRESSOR | | 著者 | Salinas, R.K, Folkers, G.E, Bonvin, A.M.J.J, Das, D, Boelens, R, Kaptein, R. | | 登録日 | 2005-02-01 | | 公開日 | 2005-10-18 | | 最終更新日 | 2020-01-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Altered Specificity in DNA Binding by the Lac Repressor: A Mutant Lac Headpiece that Mimics the Gal Repressor
Chembiochem, 6, 2005
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1HRA
 | | THE SOLUTION STRUCTURE OF THE HUMAN RETINOIC ACID RECEPTOR-BETA DNA-BINDING DOMAIN | | 分子名称: | RETINOIC ACID RECEPTOR, ZINC ION | | 著者 | Knegtel, R.M.A, Katahira, M, Schilthuis, J.G, Bonvin, A.M.J.J, Boelens, R, Eib, D, Van Der Saag, P.T, Kaptein, R. | | 登録日 | 1993-07-25 | | 公開日 | 1994-01-31 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of the human retinoic acid receptor-beta DNA-binding domain.
J.Biomol.NMR, 3, 1993
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2MUT
 | | Solution structure of the F231L mutant ERCC1-XPF dimerization region | | 分子名称: | DNA excision repair protein ERCC-1, DNA repair endonuclease XPF | | 著者 | Faridounnia, M, Wienk, H, Kovacic, L, Folkers, G.E, Jaspers, N.G.J, Kaptein, R, Hoeijmakers, J.H.J, Boelens, R. | | 登録日 | 2014-09-17 | | 公開日 | 2015-06-24 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The Cerebro-oculo-facio-skeletal Syndrome Point Mutation F231L in the ERCC1 DNA Repair Protein Causes Dissociation of the ERCC1-XPF Complex.
J.Biol.Chem., 290, 2015
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1CCN
 | | DIRECT NOE REFINEMENT OF CRAMBIN FROM 2D NMR DATA USING A SLOW-COOLING ANNEALING PROTOCOL | | 分子名称: | CRAMBIN | | 著者 | Bonvin, A.M.J.J, Rullmann, J.A.C, Lamerichs, R.M.J.N, Boelens, R, Kaptein, R. | | 登録日 | 1993-04-14 | | 公開日 | 1993-10-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Direct NOE refinement of biomolecular structures using 2D NMR data
J.Biomol.NMR, 1, 1991
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1CCM
 | | DIRECT NOE REFINEMENT OF CRAMBIN FROM 2D NMR DATA USING A SLOW-COOLING ANNEALING PROTOCOL | | 分子名称: | CRAMBIN | | 著者 | Bonvin, A.M.J.J, Rullmann, J.A.C, Lamerichs, R.M.J.N, Boelens, R, Kaptein, R. | | 登録日 | 1993-04-14 | | 公開日 | 1993-10-31 | | 最終更新日 | 2017-11-29 | | 実験手法 | SOLUTION NMR | | 主引用文献 | "Ensemble" iterative relaxation matrix approach: a new NMR refinement protocol applied to the solution structure of crambin.
Proteins, 15, 1993
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3RJ9
 | | Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+ | | 分子名称: | Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Morgunova, E, Wuxiuer, Y, Cols, N, Popov, A, Sylte, I, Karshikoff, A, Gonzales-Duarte, R, Ladenstein, R, Winberg, J.O. | | 登録日 | 2011-04-15 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity.
Febs J., 279, 2012
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1L1M
 | | SOLUTION STRUCTURE OF A DIMER OF LAC REPRESSOR DNA-BINDING DOMAIN COMPLEXED TO ITS NATURAL OPERATOR O1 | | 分子名称: | 5'-D(*AP*AP*AP*TP*TP*GP*TP*TP*AP*TP*CP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3', 5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*GP*AP*TP*AP*AP*CP*AP*AP*TP*TP*T)-3', Lactose operon repressor | | 著者 | Kalodimos, C.G, Bonvin, A.M.J.J, Salinas, R.K, Wechselberger, R, Boelens, R, Kaptein, R. | | 登録日 | 2002-02-19 | | 公開日 | 2002-06-26 | | 最終更新日 | 2021-10-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Plasticity in protein-DNA recognition: lac repressor interacts with its natural operator 01 through alternative conformations of its DNA-binding domain.
EMBO J., 21, 2002
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1GP1
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3RJ5
 | | Structure of alcohol dehydrogenase from Drosophila lebanonesis T114V mutant complexed with NAD+ | | 分子名称: | ACETIC ACID, Alcohol dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | 著者 | Morgunova, E, Wuxiuer, Y, Cols, N, Popov, A, Sylte, I, Karshikoff, A, Gonzales-Duarte, R, Ladenstein, R, Winberg, J.O. | | 登録日 | 2011-04-15 | | 公開日 | 2012-05-02 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | An intact eight-membered water chain in drosophilid alcohol dehydrogenases is essential for optimal enzyme activity.
Febs J., 279, 2012
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1HWT
 | | STRUCTURE OF A HAP1/DNA COMPLEX REVEALS DRAMATICALLY ASYMMETRIC DNA BINDING BY A HOMODIMERIC PROTEIN | | 分子名称: | DNA (5'-D(*GP*CP*GP*CP*TP*AP*TP*TP*AP*TP*CP*GP*CP*TP*AP*TP*TP*AP*GP*C)-3'), DNA (5'-D(*GP*CP*TP*AP*AP*TP*AP*GP*CP*GP*AP*TP*AP*AP*TP*AP*GP*CP*GP*C)-3'), PROTEIN (HEME ACTIVATOR PROTEIN), ... | | 著者 | King, D.A, Zhang, L, Guarente, L, Marmorstein, R. | | 登録日 | 1998-09-17 | | 公開日 | 1999-11-10 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein.
Nat.Struct.Biol., 6, 1999
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3Q4C
 | | Crystal Structure of Wild Type BRAF kinase domain in complex with organometallic inhibitor CNS292 | | 分子名称: | Serine/threonine-protein kinase B-raf, [(1,2,3,4,5,6-eta)-(1S,2R,3R,4R,5S,6S)-1-carboxycyclohexane-1,2,3,4,5,6-hexayl](chloro)(3-methyl-5,7-dioxo-6,7-dihydro-5H-pyrido[2,3-a]pyrrolo[3,4-c]carbazol-12-ide-kappa~2~N~1~,N~12~)ruthenium(1+) | | 著者 | Xie, P, Streu, C, Qin, J, Pregman, H, Pagano, N, Meggers, E, Marmorstein, R. | | 登録日 | 2010-12-23 | | 公開日 | 2011-03-02 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | The crystal structure of BRAF in complex with an organoruthenium inhibitor reveals a mechanism for inhibition of an active form of BRAF kinase.
Biochemistry, 48, 2009
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1LQC
 | | LAC REPRESSOR HEADPIECE (RESIDUES 1-56), NMR, 32 STRUCTURES | | 分子名称: | LAC REPRESSOR | | 著者 | Slijper, M, Bonvin, A.M.J.J, Boelens, R, Kaptein, R. | | 登録日 | 1996-08-13 | | 公開日 | 1997-02-12 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined structure of lac repressor headpiece (1-56) determined by relaxation matrix calculations from 2D and 3D NOE data: change of tertiary structure upon binding to the lac operator.
J.Mol.Biol., 259, 1996
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3LBX
 | | Crystal Structure of the Erythrocyte Spectrin Tetramerization Domain Complex | | 分子名称: | Spectrin alpha chain, erythrocyte, Spectrin beta chain | | 著者 | Ipsaro, J.J, Harper, S.L, Messick, T.E, Marmorstein, R, Mondragon, A, Speicher, D.W. | | 登録日 | 2010-01-08 | | 公開日 | 2010-03-09 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure and functional interpretation of the erythrocyte spectrin tetramerization domain complex.
Blood, 115, 2010
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1E0E
 | | N-terminal zinc-binding HHCC domain of HIV-2 integrase | | 分子名称: | HUMAN IMMUNODEFICIENCY VIRUS TYPE 2 INTEGRASE, ZINC ION | | 著者 | Eijkelenboom, A.P.A.M, Van Den ent, F.M.I, Plasterk, R.H.A, Kaptein, R, Boelens, R. | | 登録日 | 2000-03-25 | | 公開日 | 2001-03-19 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Refined Solution Structure of the Dimeric N-Terminal Hhcc Domain of HIV-2 Integrase
J.Biomol.NMR, 18, 2000
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1E0H
 | | Inhibitor Protein Im9 bound to its partner E9 DNase | | 分子名称: | IMMUNITY PROTEIN FOR COLICIN E9 | | 著者 | Boetzel, R, Czisch, M, Kaptein, R, Hemmings, A.M, James, R, Kleanthous, C, Moore, G.R. | | 登録日 | 2000-03-28 | | 公開日 | 2000-10-30 | | 最終更新日 | 2024-05-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | NMR investigation of the interaction of the inhibitor protein Im9 with its partner DNase.
Protein Sci., 9, 2000
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1CJG
 | | NMR STRUCTURE OF LAC REPRESSOR HP62-DNA COMPLEX | | 分子名称: | DNA (5'-D(*GP*AP*AP*TP*TP*GP*TP*GP*AP*GP*CP*GP*CP*TP*CP*AP*CP*AP*AP*TP*TP*C)-3'), PROTEIN (LAC REPRESSOR) | | 著者 | Spronk, C.A.E.M, Bonvin, A.M.J.J, Radha, P.K, Melacini, G, Boelens, R, Kaptein, R. | | 登録日 | 1999-04-14 | | 公開日 | 2000-01-01 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | The solution structure of Lac repressor headpiece 62 complexed to a symmetrical lac operator.
Structure Fold.Des., 7, 1999
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1W29
 | | Lumazine Synthase from Mycobacterium tuberculosis bound to 3-(1,3,7- trihydro-9-D-ribityl-2,6,8-purinetrione-7-yl)butane 1-phosphate | | 分子名称: | (4S,5S)-1,2-DITHIANE-4,5-DIOL, 4-{2,6,8-TRIOXO-9-[(2R,3S,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, 4-{2,6,8-TRIOXO-9-[(2S,3R,4R)-2,3,4,5-TETRAHYDROXYPENTYL]-1,2,3,6,8,9-HEXAHYDRO-7H-PURIN-7-YL}BUTYL DIHYDROGEN PHOSPHATE, ... | | 著者 | Morgunova, E, Meining, W, Illarionov, B, Haase, I, Fischer, M, Cushman, M, Bacher, A, Ladenstein, R. | | 登録日 | 2004-07-01 | | 公開日 | 2005-03-03 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Lumazine Synthase from Mycobacterium Tuberculosis as a Target for Rational Drug Design: Binding Mode of a New Class of Purinetrione Inhibitors(,)
Biochemistry, 44, 2005
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