2M2Q
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![BU of 2m2q by Molmil](/molmil-images/mine/2m2q) | Solution structure of MCh-1: A novel inhibitor cystine knot peptide from Momordica charantia | Descriptor: | Inhibitor cystine knot peptide MCh-1 | Authors: | He, W, Chan, L, Clark, R.J, Tang, J, Zeng, G, Franco, O.L, Cantacessi, C, Craik, D.J, Daly, N.L, Tan, N. | Deposit date: | 2013-01-01 | Release date: | 2013-11-06 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Novel Inhibitor Cystine Knot Peptides from Momordica charantia. Plos One, 8, 2013
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4UIF
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![BU of 4uif by Molmil](/molmil-images/mine/4uif) | Cryo-EM structure of Dengue virus serotype 2 in complex with antigen-binding fragments of human antibody 2D22 | Descriptor: | ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - LIGHT CHAIN, DENGUE VIRUS SEROTYPE 2 STRAIN PVP94 07 - ENVELOPE PROTEIN, ... | Authors: | Fibriansah, G, Ibarra, K.D, Ng, T.-S, Smith, S.A, Tan, J.L, Lim, X.-N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe Junior, J.E, Lok, S.-M. | Deposit date: | 2015-03-30 | Release date: | 2015-07-15 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (6.5 Å) | Cite: | Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers. Science, 349, 2015
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4UIH
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![BU of 4uih by Molmil](/molmil-images/mine/4uih) | Cryo-EM structure of Dengue virus serotype 2 strain New Guinea-C complexed with human antibody 2D22 Fab at 37 degree C. The Fab molecules were added to the virus before 37 degree C incubation. | Descriptor: | ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -HEAVY CHAIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 -LIGHT CHAIN, DENGUE VIRUS SEROTYPE 2 STRAIN NEW GUINEA-C E PROTEIN ECTODOMAIN | Authors: | Fibriansah, G, Ibarra, K.D, Ng, T.-S, Smith, S.A, Tan, J.L, Lim, X.N, Ooi, J.S.G, Kostyuchenko, V.A, Wang, J, de Silva, A.M, Harris, E, Crowe, J.E, Lok, S.-M. | Deposit date: | 2015-03-30 | Release date: | 2015-07-15 | Last modified: | 2024-05-08 | Method: | ELECTRON MICROSCOPY (20 Å) | Cite: | Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers. Science, 349, 2015
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9FSE
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![BU of 9fse by Molmil](/molmil-images/mine/9fse) | Human ROR2 cysteine-rich domain (CRD) and Kringle domain | Descriptor: | SULFATE ION, Tyrosine-protein kinase transmembrane receptor ROR2 | Authors: | Griffiths, S.C, Tan, J, Wagner, A, Blazer, L.L, Adams, J.J, Srinivasan, S, Moghisaei, S, Sidhu, S.S, Siebold, C, Ho, H.H. | Deposit date: | 2024-06-20 | Release date: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Structure and function of the ROR2 cysteine-rich domain in vertebrate noncanonical WNT5A signaling. Elife, 13, 2024
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7C62
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![BU of 7c62 by Molmil](/molmil-images/mine/7c62) | |
7CMR
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![BU of 7cmr by Molmil](/molmil-images/mine/7cmr) | The Crystal Structure of human MYST1 from Biortus. | Descriptor: | GLYCEROL, Histone acetyltransferase KAT8, ZINC ION | Authors: | Wang, F, Lin, D, Lv, Z, Xu, X, Tan, J, Shang, H. | Deposit date: | 2020-07-28 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | The Crystal Structure of human MYST1 from Biortus. To Be Published
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4U8I
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![BU of 4u8i by Molmil](/molmil-images/mine/4u8i) | Structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant F66A | Descriptor: | 1,2-ETHANEDIOL, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SULFATE ION, ... | Authors: | Qureshi, I.A, Chaudhary, R, Tanner, J.J. | Deposit date: | 2014-08-03 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics. Biochemistry, 53, 2014
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4U8P
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![BU of 4u8p by Molmil](/molmil-images/mine/4u8p) | Structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant Y317A complexed with UDP | Descriptor: | 1,2-ETHANEDIOL, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SULFATE ION, ... | Authors: | Qureshi, I.A, Chaudhary, R, Tanner, J.J. | Deposit date: | 2014-08-03 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics. Biochemistry, 53, 2014
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4U8O
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![BU of 4u8o by Molmil](/molmil-images/mine/4u8o) | Structure of Aspergillus fumigatus UDP-Galactopyranose mutase mutant N207A complexed with UDP | Descriptor: | 1,2-ETHANEDIOL, DIHYDROFLAVINE-ADENINE DINUCLEOTIDE, SULFATE ION, ... | Authors: | Qureshi, I.A, Chaudhary, R, Tanner, J.J. | Deposit date: | 2014-08-03 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics. Biochemistry, 53, 2014
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6QN0
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![BU of 6qn0 by Molmil](/molmil-images/mine/6qn0) | |
6QNL
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![BU of 6qnl by Molmil](/molmil-images/mine/6qnl) | |
1R42
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![BU of 1r42 by Molmil](/molmil-images/mine/1r42) | Native Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ZINC ION, ... | Authors: | Towler, P, Staker, B, Prasad, S.G, Menon, S, Ryan, D, Tang, J, Parsons, T, Fisher, M, Williams, D, Dales, N.A, Patane, M.A, Pantoliano, M.W. | Deposit date: | 2003-10-07 | Release date: | 2004-02-03 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J.Biol.Chem., 279, 2004
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1R4L
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![BU of 1r4l by Molmil](/molmil-images/mine/1r4l) | Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2) | Descriptor: | (S,S)-2-{1-CARBOXY-2-[3-(3,5-DICHLORO-BENZYL)-3H-IMIDAZOL-4-YL]-ETHYLAMINO}-4-METHYL-PENTANOIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Towler, P, Staker, B, Prasad, S.G, Menon, S, Ryan, D, Tang, J, Parsons, T, Fisher, M, Williams, D, Dales, N.A, Patane, M.A, Pantoliano, M.W. | Deposit date: | 2003-10-07 | Release date: | 2004-02-03 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J.Biol.Chem., 279, 2004
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6QNG
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4BEY
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![BU of 4bey by Molmil](/molmil-images/mine/4bey) | Night blindness causing G90D rhodopsin in complex with GaCT2 peptide | Descriptor: | ACETATE ION, Guanine nucleotide-binding protein G(t) subunit alpha-1, PALMITIC ACID, ... | Authors: | Singhal, A, Ostermaier, M.K, Vishnivetskiy, S.A, Panneels, V, Homan, K.T, Tesmer, J.J.G, Veprintsev, D, Deupi, X, Gurevich, V.V, Schertler, G.F.X, Standfuss, J. | Deposit date: | 2013-03-12 | Release date: | 2013-05-08 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Insights Into Congenital Stationary Night Blindness Based on the Structure of G90D Rhodopsin. Embo Rep., 14, 2013
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2AY0
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![BU of 2ay0 by Molmil](/molmil-images/mine/2ay0) | Structure of the Lys9Met mutant of the E. coli Proline Utilization A (PutA) DNA-binding domain. | Descriptor: | Bifunctional putA protein, CHLORIDE ION | Authors: | Larson, J.D, Schuermann, J.P, Zhou, Y, Jenkins, J.L, Becker, D.F, Tanner, J.J. | Deposit date: | 2005-09-06 | Release date: | 2006-08-15 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition. Protein Sci., 15, 2006
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4BHF
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![BU of 4bhf by Molmil](/molmil-images/mine/4bhf) | Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 4-(Trimethylammonio)pentanoate | Descriptor: | 4-(Trimethylammonio)pentanoic acid, GAMMA-BUTYROBETAINE DIOXYGENASE, HEXANE-1,6-DIAMINE, ... | Authors: | Tars, K, Leitans, J, Kazaks, A. | Deposit date: | 2013-04-02 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase. J.Med.Chem., 57, 2014
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4BHI
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![BU of 4bhi by Molmil](/molmil-images/mine/4bhi) | Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 3-(1,1,1,2-Tetramethylhydrazin-1-ium-2-yl)propanoate | Descriptor: | 3-(1,1,1,2-TETRAMETHYLHYDRAZIN-1-IUM-2-YL)PROPANOATE, GAMMA-BUTYROBETAINE DIOXYGENASE, HEXANE-1,6-DIAMINE, ... | Authors: | Tars, K, Leitans, J, Kazaks, A. | Deposit date: | 2013-04-03 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase. J.Med.Chem., 57, 2014
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4BG1
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![BU of 4bg1 by Molmil](/molmil-images/mine/4bg1) | Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 1-(3-Carboxypropyl)-1-methylpyrrolidin-1-ium chloride | Descriptor: | 1-(3-carboxypropyl)-1-methylpyrrolidin-1-ium, GAMMA-BUTYROBETAINE DIOXYGENASE, HEXANE-1,6-DIAMINE, ... | Authors: | Tars, K, Leitans, J, Kazaks, A. | Deposit date: | 2013-03-22 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase. J.Med.Chem., 57, 2014
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4BGM
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![BU of 4bgm by Molmil](/molmil-images/mine/4bgm) | Three dimensional structure of human gamma-butyrobetaine hydroxylase in complex with 3-Carboxy-N-(2-fluoroethyl)-N,N-dimethylpropan-1- aminium chloride | Descriptor: | 3-Carboxy-N-(2-fluoroethyl)-N,N-dimethylpropan-1-aminium, GAMMA-BUTYROBETAINE DIOXYGENASE, HEXANE-1,6-DIAMINE, ... | Authors: | Tars, K, Leitans, J, Kazaks, A. | Deposit date: | 2013-03-27 | Release date: | 2014-03-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Targeting Carnitine Biosynthesis: Discovery of New Inhibitors Against Gamma-Butyrobetaine Hydroxylase. J.Med.Chem., 57, 2014
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4ZUK
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![BU of 4zuk by Molmil](/molmil-images/mine/4zuk) | Structure ALDH7A1 complexed with NAD+ | Descriptor: | Alpha-aminoadipic semialdehyde dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, TETRAETHYLENE GLYCOL | Authors: | Luo, M, Tanner, J.J. | Deposit date: | 2015-05-16 | Release date: | 2015-08-26 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.001 Å) | Cite: | Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1. Biochemistry, 54, 2015
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4ZUL
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![BU of 4zul by Molmil](/molmil-images/mine/4zul) | Structure ALDH7A1 complexed with alpha-aminoadipate | Descriptor: | 2-AMINOHEXANEDIOIC ACID, Alpha-aminoadipic semialdehyde dehydrogenase, TETRAETHYLENE GLYCOL, ... | Authors: | Luo, M, Tanner, J.J. | Deposit date: | 2015-05-16 | Release date: | 2015-08-26 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1. Biochemistry, 54, 2015
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3O5Z
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![BU of 3o5z by Molmil](/molmil-images/mine/3o5z) | Crystal structure of the SH3 domain from p85beta subunit of phosphoinositide 3-kinase (PI3K) | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, Phosphatidylinositol 3-kinase regulatory subunit beta | Authors: | Chen, S, Xiao, Y, Ponnusamy, R, Tan, J, Lei, J, Hilgenfeld, R. | Deposit date: | 2010-07-28 | Release date: | 2011-08-10 | Last modified: | 2014-09-10 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | X-ray structure of the SH3 domain of the phosphoinositide 3-kinase p85 beta subunit Acta Crystallogr.,Sect.F, 67, 2011
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3J6S
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![BU of 3j6s by Molmil](/molmil-images/mine/3j6s) | Cryo-EM structure of Dengue virus serotype 3 at 28 degrees C | Descriptor: | envelope protein, membrane protein | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | Deposit date: | 2014-03-24 | Release date: | 2015-03-04 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (6 Å) | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins. Nat Commun, 6, 2015
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3J6U
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![BU of 3j6u by Molmil](/molmil-images/mine/3j6u) | Cryo-EM structure of Dengue virus serotype 3 in complex with human antibody 5J7 Fab | Descriptor: | Fab 5J7 heavy chain, Fab 5J7 light chain, envelope protein, ... | Authors: | Fibriansah, G, Tan, J.L, Smith, S.A, de Alwis, R, Ng, T.-S, Kostyuchenko, V.A, Kukkaro, P, de Silva, A.M, Crowe Jr, J.E, Lok, S.-M. | Deposit date: | 2014-03-26 | Release date: | 2015-03-04 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (9 Å) | Cite: | A highly potent human antibody neutralizes dengue virus serotype 3 by binding across three surface proteins. Nat Commun, 6, 2015
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