1R4L

Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)

Summary for 1R4L
Related1R42
Descriptorangiotensin I converting enzyme 2, disordered segment of collectrin homology domain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywordszinc metallopeptidase domain, collectrin homology domain, inhibitor bound conformation, chloride ion binding site, zinc ion binding site, hydrolase
Biological sourceHomo sapiens (human)
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Total number of polymer chains5
Total formula weight76979.55
Authors
Towler, P.,Staker, B.,Prasad, S.G.,Menon, S.,Ryan, D.,Tang, J.,Parsons, T.,Fisher, M.,Williams, D.,Dales, N.A.,Patane, M.A.,Pantoliano, M.W. (deposition date: 2003-10-07, release date: 2004-02-03, Last modification date: 2020-07-29)
Primary citationDales, N.A.,Fisher, M.,Menon, S.,Pantoliano, M.W.,Parsons, T.,Patane, M.A.,Prasad, S.G.,Ryan, D.,Staker, B.,Tang, J.,Towler, P.,Williams, D.
ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis.
J.Biol.Chem., 279:17996-18007, 2004
PubMed: 14754895
DOI: 110.1074/jbc.M311191200
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation
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PDB entries from 2021-06-16