1R4L

Inhibitor Bound Human Angiotensin Converting Enzyme-Related Carboxypeptidase (ACE2)

Summary for 1R4L

Entry DOI	10.2210/pdb1r4l/pdb
Related	1R42
Descriptor	angiotensin I converting enzyme 2, disordered segment of collectrin homology domain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
Functional Keywords	zinc metallopeptidase domain, collectrin homology domain, inhibitor bound conformation, chloride ion binding site, zinc ion binding site, hydrolase
Biological source	Homo sapiens (human) More
Total number of polymer chains	5
Total formula weight	76979.55
Authors	Towler, P.,Staker, B.,Prasad, S.G.,Menon, S.,Ryan, D.,Tang, J.,Parsons, T.,Fisher, M.,Williams, D.,Dales, N.A.,Patane, M.A.,Pantoliano, M.W. (deposition date: 2003-10-07, release date: 2004-02-03, Last modification date: 2023-08-23)
Primary citation	Towler, P.,Staker, B.,Prasad, S.G.,Menon, S.,Tang, J.,Parsons, T.,Ryan, D.,Fisher, M.,Williams, D.,Dales, N.A.,Patane, M.A.,Pantoliano, M.W. ACE2 X-ray structures reveal a large hinge-bending motion important for inhibitor binding and catalysis. J.Biol.Chem., 279:17996-18007, 2004 Cited by PubMed: 14754895 DOI: 10.1074/jbc.M311191200 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3 Å)

Structure validation