4UIF

Cryo-EM structure of Dengue virus serotype 2 in complex with antigen-binding fragments of human antibody 2D22

Summary for 4UIF

• Entry DOI: 10.2210/pdb4uif/pdb
• Related: 4UIH
• EMDB information: 2967
• Descriptor: DENGUE VIRUS SEROTYPE 2 STRAIN PVP94 07 - ENVELOPE PROTEIN, DENGUE VIRUS SEROTYPE 2 STRAIN STRAIN PVP94 07 - MEMBRANE PROTEIN, ANTIGEN-BINDING FRAGMENT OF HUMAN ANTIBODY 2D22 - HEAVY CHAIN, ... (4 entities in total)
• Functional Keywords: viral protein, dengue virus, human antibody, cryo-em, neutralization
• Biological source: DENGUE VIRUS 2; More
• Cellular location: Host endoplasmic reticulum membrane ; Multi-pass membrane protein : D6MQ38; Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Lumenal side : E0WXJ3
• Total number of polymer chains: 12
• Total formula weight: 264791.42

Authors

Fibriansah, G.,Ibarra, K.D.,Ng, T.-S.,Smith, S.A.,Tan, J.L.,Lim, X.-N.,Ooi, J.S.G.,Kostyuchenko, V.A.,Wang, J.,de Silva, A.M.,Harris, E.,Crowe Junior, J.E.,Lok, S.-M. (deposition date: 2015-03-30, release date: 2015-07-15, Last modification date: 2018-02-07)

• Primary citation: Fibriansah, G.,Ibarra, K.D.,Ng, T.S.,Smith, S.A.,Tan, J.L.,Lim, X.N.,Ooi, J.S.,Kostyuchenko, V.A.,Wang, J.,de Silva, A.M.,Harris, E.,Crowe, J.E.,Lok, S.M.; Cryo-EM structure of an antibody that neutralizes dengue virus type 2 by locking E protein dimers.; Science, 349:88-91, 2015; PubMed: 26138979; DOI: 10.1126/science.aaa8651

Experimental method

ELECTRON MICROSCOPY (6.5 Å)